1,721,009 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Novel laboratory markers for diagnosis and monitoring of ANCA associated vasculitis and idiopathic inflammatory myopathies interstitial lung disease
No full textINTRODUCTION
Interstitial lung disease (ILD) may complicate the course of systemic autoimmune rheumatic disease (SARD), particularly ANCA associated vasculitis (AAV) and idiopathic inflammatory myopathies (IIM). Here, we explored the landscape of serum biomarkers in idiopathic and SARD-ILD in four different setting.
First, as a proof of concept, preliminary study, we evaluated IL-6, SMRP, KL-6 and ferritin in idiopathic and SARD-ILD in a large cohort of patients from the UK Biomarkers in Interstitial Lung Disease (UK-BILD) Study. Secondly, we aimed to assess whether serum ferritin could be considered a specific and sensitive biomarker for IIM-ILD, as well as to assess whether it correlates with clinical, radiological, functional and routine laboratory findings. As a corollary, some IIM patients from this cohort were furtherly studied in order to assess the prevalence of subclinical renal injury by elevated NGAL, KIM1, Activin A, CD163, and Cys-s. Finally, given the evidence coming from the previous studies for the abovementioned biomarkers, we prospectively studied a cohort of AAV, with and without ILD, in order to evaluate serum CD163 and KL6 levels and whether their levels correlate with disease severity and extent. Subsequently, a proof-of-concept, corollary study, ILD-AAV patients were treated with a protocol of Rituximab (RTX) and a short dosage of GCs in order to assess whether this scheme could be effective in stabilizing respiratory functional parameters and imaging findings.
METHODS
Patients included in the UK-BILD Study” were retrospectively enrolled from 39 UK recruitment centers. Inclusion criteria were a diagnosis of IPF, idiopathic NSIP and SARD-ILD. Serum samples were obtained from recruited patients, anonymized in an electronic database and marker concentrations were measured singly by KL-6, IL-6, FER and SMRP reagent assays. Patients were further stratified according to HRCT findings and comparative analysis of serum marker concentrations were performed within and between groups. For ferritin evaluation, all patients affected by IIM and followed at Siena (Italy), Palermo (Italy), Bari (Italy) and Lucknow, (India) IIM referral centers were retrospectively included. Primary endpoints were to assess whether abnormal ferritin serum levels are associated with the presence of ILD and to evaluate whether high ferritin serum levels can be evidenced only in anti-MDA5 DM or also in ASS ILD. In order to evaluate urinary biomarkers in IIM, clinical data, core set measures, sera and urine were prospectively collected from all patients enrolled in the MyoCite cohort from 2017 to 2021. Twenty healthy individuals (HCs) and 16 patients affected by acute kidney injury were included as a control group. For patients with IIMs, data from both baseline and follow-up visits within the observational period were included. Finally, for ILD-AAV study, patients with MPA or GPA with and without ILD were prospectively collected and treated with RTX and oral GCs according to PEXIVAS protocol, measuring serum CD163 and KL6 levels.
RESULTS
1013 patients were selected: 520 (51.3%) had idiopathic ILD and 493 SARD-ILD. Idiopathic ILD patients displayed higher KL-6 values than SARD-ILD. Ferritin and SMRP, though within normal ranges, were significantly higher in idiopathic ILD. Logistic regression showed good sensitivity and specificity selecting the variables ferritin and KL-6 concentrations, age and gender-male correlated with a diagnosis of idiopathic ILD. A total of 139 IIM patients underwent ferritin measurement. When patients were stratified between ASS, DM and anti-MDA5 DM, a statistically significant difference was found only for ferritin, which was positively associated with the presence of anti-MDA5-DM with ILD. ROC curve analysis obtained a significant AUROC with the best cut-off value of 303.5 for distinguishing ASS and MDA5-DM with ILD. Analysis of 201 visits of 110 adult patients with IIMs indicated higher normalized biomarker levels compared to HCs, and comparable to patients with AKI, with the exception of NGAL, which was higher in the AKI group. Notably, 49% patients with IIMs had eGFR<90; the levels of the 5 biomarkers were comparable between active and inactive IIMs, and different subtypes of IIMs. Similarly, a poor correlation between urine biomarker levels and core set measures of activity and damage was found. Changes in biomarker levels on follow-up did not correlate with eGFR changes.
Eight patients, 3 affected by GPA and 5 by MPA, were included in AAV-ILD study. All but one displayed positivity for anti-MPO and 3 of them did not have any extra-pulmonary sign of vasculitis. At baseline, LFT evidenced a restrictive pattern (mean FVC 83%) associated with a moderate impairment of diffusion capacity (mean DLCO 54%). After 6 and 12 months, a stabilization of LFT findings was evidenced, while no sign of progression of ILD was assessed at CT scan. No patient suffered from severe AE, except one who had bacterial pneumonia. All patients but three discontinued GCs.
DISCUSSION
Our study showed the excellent diagnostic value of KL-6 for detecting ILD, which irrespective of the final diagnosis and extent of disease, is always elevated and is a reliable biomarker of lung fibrosis in various diseases, ranging from idiopathic to autoimmune forms. Our study proposed an ILD differentiation model including clinical background. Moreover, in a large, multicentric, international cohort, we evidenced that serum, ferritin represents a reliable and specific biomarker for the diagnosis of patients with MDA5-ILD. Ferritin represents the sole clinical and serological feature able to address to a positivity of MDA5, as well as to distinguish between ASS and anti-MDA5-DM with ILD. At the same time, exploratory analysis of urinary biomarkers identified low eGFR and elevated biomarkers of CKD in nearly half of the patients with IIMs, comparable to patients with AKI and higher than HCs, indicative of potential renal damage in IIMs that may have a lead to complications in other systems. Finally, through the first prospective study specifically designed to evaluate the efficacy of RTX in AAV-ILD. Our findings have displayed that RTX, prescribed in association with a short course of GCs, is able to stabilize imaging features and respiratory functionality
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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