1,721,020 research outputs found

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Cost-Effectiveness of Adrenaline Autoinjectors for Children with Food Allergy

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    Full Text is available to authenticated members of The University of Auckland only.Children with food allergy live with the risk of anaphylaxis, a life-threatening allergic reaction which requires emergency treatment with an adrenaline autoinjector. The only brand of autoinjector available in New Zealand is the EpiPen, which retails for a minimum of 120andisnotpubliclyfunded.Thishighpricepresentsabarriertoaccess,butmultiplecampaignsbytheallergycommunityhavebeenunsuccessfulwiththePharmaceuticalManagementAgency(PHARMAC)decidingnottoprioritiseEpiPenfunding,potentiallyduetopoorcosteffectivenessinpreviousanalyses.ThisresearchaimedtoevaluatethecosteffectivenessofEpiPenadrenalineautoinjectorsforchildrenwithfoodallergy.Twopotentialfundingstrategieswereconsidered:(i)fullyfundedEpiPensonindividualprescriptionand(ii)fundedschoolbasedEpiPens.AMarkovdecisionanalyticmodelwasbuiltbasedonthenaturalhistoryoffoodinducedanaphylaxis.Themodelfollowedahypotheticalcohortofchildrenfromfiveyearsto18yearsofageordeath,throughrecurrenceandtreatmentpathways.Transitionprobabilitiesandutilityvalueswereobtainedfrompublishedliteratureandexpertopinion;costswereestimatedfromretailandfromnationalandregionalfundingbodies.Outcomeswereexpressedascostsincurredandqualityadjustedlifeyears(QALYs)gained.Inaddition,allergycliniciansandschoolprincipalswereinterviewedabouttheirviewsregardingfundedschoolbasedEpiPens,andathematicanalysisofinterviewtranscriptswascarriedout.PubliclyfundedschoolbasedEpiPenswerepredictedtobecosteffectiveatwillingnesstopaythresholdsbetween120 and is not publicly funded. This high price presents a barrier to access, but multiple campaigns by the allergy community have been unsuccessful with the Pharmaceutical Management Agency (PHARMAC) deciding not to prioritise EpiPen funding, potentially due to poor cost-effectiveness in previous analyses. This research aimed to evaluate the cost-effectiveness of EpiPen adrenaline autoinjectors for children with food allergy. Two potential funding strategies were considered: (i) fully-funded EpiPens on individual prescription and (ii) funded school-based EpiPens. A Markov decision-analytic model was built based on the natural history of food-induced anaphylaxis. The model followed a hypothetical cohort of children from five years to 18 years of age or death, through recurrence and treatment pathways. Transition probabilities and utility values were obtained from published literature and expert opinion; costs were estimated from retail and from national and regional funding bodies. Outcomes were expressed as costs incurred and quality-adjusted life years (QALYs) gained. In addition, allergy clinicians and school principals were interviewed about their views regarding funded school-based EpiPens, and a thematic analysis of interview transcripts was carried out. Publicly-funded school-based EpiPens were predicted to be cost-effective at willingness-to-pay thresholds between 2,051 and 8,586perQALY.FullyfundedEpiPensproducedthelargestQALYgainandwerecosteffectiveatthresholdsabove8,586 per QALY. Fully-funded EpiPens produced the largest QALY gain and were cost-effective at thresholds above 8,586 per QALY. If either strategy were to be implemented, price negotiations and policy decisions such as the number of devices required per school will affect the thresholds at which each strategy is considered cost-effective. Introducing funded EpiPens is likely feasible and may help alleviate the psychological and financial burden of anaphylaxis for affected families but would require government agencies to prioritise anaphylaxis as a public health issue of importance

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Author Index

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    koamabayili/VECTRON-author-checklist: VECTRON author checklist

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    We have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used

    PROM-ising outcomes for medical devices: A systematic review and environmental scan of patient-reported outcome measures in the context of medical devices

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    Rapid innovation in medical technologies is transforming healthcare in the 21st century and driving significant improvements in patient health outcomes, quality of life, and longevity. However, alongside these game-changing technologies are also high costs associated with developing and commercialising these technologies. These costs affect how healthcare payers assess which modern inventions to invest in and get to patients who need them most. The challenge of how medical devices can be ‘better’ evaluated to enable faster and more equitable access is multifaceted and complex. Multiple components of the public procurement process must be refined and harmonised to ‘improve’ the process for assessing health investments. This thesis is interested in the relationship between the regulatory approval of high-risk medical devices, the evidence required for those processes, and the economic evaluations and associated evidence needed to demonstrate the cost-effectiveness of such devices, often for public procurement processes. Using the example of high-risk cardiology medical devices, this thesis explores the intersection between the regulatory and health system contexts within the bounds of how and where Patient Reported Outcome Measures (PROMs) contribute toward the regulatory approval and procurement of high-risk medical devices. This research aims to understand further where there is concurrency and where there are differences in how PROMs are implemented and used for regulatory approvals compared to health economic evaluations to demonstrate cost-effectiveness. The research was carried out in two parts; first, a systematic review investigating the cost and outcome inputs currently used in global economic evaluations of medical devices; the other part was an environmental scan of grey literature published by industry bodies and regulatory authorities in three major Western regulatory English-speaking jurisdictions: The United States of America, the European Union, and Australia. What was found was a dissonance in the clinical outcome assessments (including PROMs) included in the economic evaluations of the systematic review and the recommendations extracted from the published grey literature of the environmental scan. This thesis provides an assessment of the differences in patient-generated outcomes utilised at these two phases of a medical device’s product lifecycle and contributes analysis and insights to support future research efforts to better harmonise the implementation and utilisation of PROMs as evidence for either regulatory approval or economic evaluations of medical devices
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