6 research outputs found
Forward osmosis for Desalination.
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Backend Construction of a Web Service
No full textabstract: A growing number of stylists \u2014 cosmetologists \u2014 are finding it harder to afford the basic necessities such as rent. However, the ever-increasing presence of smartphones and the increasing need for on-demand services like Uber and Uber Eats creates a unique opportunity for stylists \u2014 Clippr. Clippr is an application that aims to connect individual stylists directly to their customers. The application gives stylists a platform to create and display their own prices, services, and portfolio. Customers get the benefit of finding a stylist that suits them and booking instantly. This project outlines the backend for the Clippr application. It goes over the framework, REST API, and various functionalities of the application. Additionally, the project also covers the work that is still needed to successfully launch the application
Capital Efficiency Metrics
No full textabstract: We gathered and analyzed key data from a wide-range of competitors in the foundry, fabless, and Integrated design manufacturing business. After detecting a downward trend in the return of invested capital (ROIC) and higher capital intensity of Company X, we searched for alternatives to turn this around. We conclude that, to decrease the net PPE of Company X, a sale-leaseback transaction would help Company X reduce their balance sheet and provided financing to advance their manufacturing capabilities
Mixed squamous – neuroendocrine carcinoma of the gallbladder: A case report of a rare pathological entity
No full textGallbladder cancers are the most common biliary tract malignancies in the world. Adenocarcinoma constitutes the most common histology in gallbladder cancer. Neuroendocrine neoplasms of the gallbladder account for about 0.5% of all neuroendocrine neoplasms and 2.1% of all gallbladder tumors. They are rare tumors and present with non-specific symptoms such as abdominal pain, weight loss, anorexia, and obstructive jaundice, and, therefore, are often challenging to diagnose and treat. Mixed neuroendocrine-non-neuroendocrine neoplasm is a subtype of neuroendocrine neoplasm. To add to the literature, we report a rare case of a patient who presented with pain in the abdomen and non-bilious vomiting and was diagnosed with mixed neuroendocrine-non-neuroendocrine gallbladder cancer, identified by immunohistochemistry, and treated with palliative chemotherapy. Due to non-specific symptoms, patients may present at an advanced stage. Further, immunohistochemistry may assist in clinching the diagnosis
Prognostic value of the combination of serial APACHE II with serum lactate for predicting post-operative mortality in gastrointestinal perforation peritonitis: a prospective cohort study
No full textAbstract Background Gastrointestinal perforation peritonitis is a life-threatening surgical emergency with high mortality. Early identification of patients at increased risk of poor outcomes is critical for optimizing care. In this study, we aimed to evaluate the prognostic value of combining serial Acute Physiology and Chronic Health Evaluation II (APACHE II) scores and serial serum lactate levels in predicting 30-day postoperative mortality among patients undergoing emergency laparotomy for gastrointestinal perforation peritonitis. Methods In this prospective cohort study, 120 adult patients diagnosed with gastrointestinal perforation peritonitis and undergoing emergency laparotomy were enrolled after obtaining ethical approval and informed consent. APACHE II scores and serum lactate levels were recorded at three time points: preoperatively (baseline), 6 h postoperatively, and 24 h postoperatively. The primary objective of this study was a combination of serial APACHE II and serial serum lactate level (baseline, 6 h and 24 h post-operatively) and its correlation with post-operative mortality in emergency laparotomy for hollow viscus perforation peritonitis. Data were analysed to compare clinical variables between survivors and non-survivors. Receiver operating characteristic (ROC) curves and area under the curve (AUC) analyses were used to assess the predictive performance of individual and combined markers. Results The 30-day postoperative mortality rate was 35%. Significant differences in age, serial APACHE II scores, and serial serum lactate levels were observed between survivors and non-survivors. A serum lactate level of ≥ 1.88 mmol/L had a sensitivity of 81% and specificity of 69.2% (AUC: 0.817; p = 0.0001). APACHE II scores of ≥ 11.16 yielded a sensitivity of 76.2% and specificity of 91% (AUC: 0.915; p = 0.0001). Both serial lactate levels and APACHE II scores were independent predictors of 30-day mortality. The combination of serial APACHE II scores and serum lactate (cutoff ≥ 11.95) had a sensitivity of 85%, specificity of 82%, and an AUC of 0.919 (p = 0.0001), making it the preferred predictor for 30-day post-operative mortality. Conclusions The combination of serial APACHE II scores and serial serum lactate levels provides superior prognostic accuracy for predicting 30-day postoperative mortality in patients undergoing emergency laparotomy for gastrointestinal perforation peritonitis. This approach may facilitate early identification of high-risk patients and guide clinical decision-making. Trial registration Not applicable
Global 30-day morbidity and mortality of surgery for perforated peptic ulcer: GRACE study
No full textBackground
There is little international data on morbidity and mortality of surgery for perforated peptic ulcer (PPU). This study aimed to understand the global 30-day morbidity and mortality of patients undergoing surgery for PPU and to identify variables associated with these.
Method
We performed an international study of adults (≥ 18 years) who underwent surgery for PPU from 1st January 2022 to 30th June 2022. Patients who were treated conservatively or had an underlying gastric cancer were excluded. Patients were divided into subgroups according to age (≤ 50 and > 50 years) and time from onset of symptoms to hospital presentation (≤ 24 and > 24 h). Univariate and Multivariate analyses were carried out to identify factors associated with higher 30-day morbidity and mortality.
Results
1874 patients from 159 centres across 52 countries were included. 78.3% (n = 1467) of the patients were males and the median (IQR) age was 49 years (25). Thirty-day morbidity and mortality were 48.5% (n = 910) and 9.3% (n = 174) respectively. Median (IQR) hospital stay was 7 (5) days. Open surgery was performed in 80% (n = 1505) of the cohort. Age > 50 years [(OR = 1.7, 95% CI 1.4–2), (OR = 4.7, 95% CI 3.1–7.6)], female gender [(OR = 1.8, 95% CI 1.4–2.3), (OR = 1.9, 95% CI 1.3–2.9)], shock on admission [(OR = 2.1, 95% CI 1.7–2.7), (OR = 4.8, 95% CI 3.2–7.1)], and acute kidney injury [(OR = 2.5, 95% CI 1.9–3.2), (OR = 3.9), 95% CI 2.7–5.6)] were associated with both 30-day morbidity and mortality. Delayed presentation was associated with 30-day morbidity [OR = 1.3, 95% CI 1.1–1.6], but not mortality.
Conclusions
This study showed that surgery for PPU was associated with high 30-day morbidity and mortality rate. Age, female gender, and signs of shock at presentation were associated with both 30-day morbidity and mortality
