100,805 research outputs found
Intellectual disability in a forensic psychiatric setting
No full textThe main focus of this thesis was to increase knowledge of offenders with ID in forensic psychiatric settings. Offenders with ID constitute a subgroup of offenders, and they have played a peripheral role in previous research on offenders with mental disorders. One explanation might be the differences in classification and diagnostics of ID in research settings, reflected in the heterogeneity of the group. As a result, evidence-based programs for treatment of offenders with ID are lacking. However, the challenges that these individuals face are substantial, and to provide individualized care and prevent criminal recidivism, a deeper understanding of these offenders is needed.List of scientific papersI. Edberg, H., Chen, Q., Andiné, P., Larsson, H., Hirvikoski, T. Clinical characteristics and pharmacological treatment of individuals with and without intellectual disability in pre-trial assessment – a population-based study. Frontiers in Psychiatry. 2020, 11, 573989. https://doi.org/10.3389/fpsyt.2020.573989 II. Edberg, H., Chen, Q., Andiné, P., Larsson, H., & Hirvikoski, T. Crimes and sentences in individuals with intellectual disability in a forensic psychiatric context: A register-based study. Epidemiology and Psychiatric Sciences. 2022, 31, E2. https://doi.org/10.1017/S2045796021000718 III. Edberg, H., Chen, Q., Andiné, P., Larsson, H., Hirvikoski, T. Treatment, adverse events, and length of stay in individuals with and without intellectual disability in forensic psychiatric care. [Submitted]IV. Edberg, H., Chen, Q., Andiné, P., Larsson, H., Hirvikoski, T. Criminal recidivism in offenders with and without intellectual disability sentenced to forensic psychiatric care in Sweden—A 17-year follow-up study. Frontiers in Psychiatry. 2022, 13(13), 1011984. https://doi.org/10.3389/fpsyt.2022.1011984 </p
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Economics and Youth Violence
No full textHow do economic conditions such as poverty, unemployment, inflation, and economic growth impact youth violence? Economics and Youth Violence provides a much-needed new perspective on this crucial issue. Pinpointing the economic factors that are most important, the editors and contributors in this volume explore how different kinds of economic issues impact children, adolescents, and their families, schools, and communities.Offering new and important insights regarding the relationship between macroeconomic conditions and youth violence across a variety of times and places, chapters cover such issues as the effect of inflation on youth violence; new quantitative analysis of the connection between race, economic opportunity, and violence; and the cyclical nature of criminal backgrounds and economic disadvantage among families. Highlighting the complexities in the relationship between economic conditions, juvenile offenses, and the community and situational contexts in which their connections are forged, Economics and Youth Violence prompts important questions that will guide future research on the causes and prevention of youth violence. Contributors: Sarah Beth Barnett, Eric P. Baumer, Philippe Bourgois, Shawn Bushway, Philip J. Cook, Robert D. Crutchfield, Linda L. Dahlberg, Mark Edberg, Jeffrey Fagan, Xiangming Fang, Curtis S. Florence, Ekaterina Gorislavsky, Nancy G. Guerra, Karen Heimer, Janet L. Lauritsen, Jennifer L. Matjasko, James A. Mercy, Matthew Phillips, Richard Rosenfeld, Tim Wadsworth, Valerie West, Kevin T. Wolf
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Measuring industry-science links through inventor-author relations: A profiling method
No full textIn this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;
Wave turbulence of a rotating array of quantized vortices in the T → 0 temperature limit
No full textThe dynamics of quantized vortices in the zero temperature limit is currently of great interest, particularly in the case of the Fermi superfluid He-B. Here we study wave turbulence, generated by the librating motion of a rotating cylindrical container filled with He-B, in the limit of vanishing viscous forces at temperatures . The polarization of the quantized vortices with respect to the axis of rotation is measured using non-invasive NMR techniques. We observe a decrease of the polarization when the librating motion is started, and a two-stage relaxation process when the modulation of the rotation velocity is stopped. The first relaxation process is associated with the dissipation of large-scale flow stored in inertial waves and the solid body rotation of the vortex array. From the decay of these energy reservoirs we determine the rate of energy dissipation of large-scale flow. The later second process is related to the relaxation of Kelvin waves on individual vortices. This process is monitored by the recovery of the polarization. The existence of a Kelvin wave cascade at the lowest temperatures is currently a central open question. We supply some evidence for the cascade
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
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