237 research outputs found
Topologic and Hemodynamic Characteristics of the Human Coronary Arterial Circulation
No full textAn overview of the experimental and simulation data based on the coronary arterial network of a single human heart as described in the listed paper. We provide data at three levels: the skeleton data, with connected voxels forming vascular segments and nodes and local estimates of vessel size (part 3), the representation as a graph in matlab (i.e. nodes and elements, or edges and vertices, part 4), and a range of excel files containing the source data for the various figures and tables, with also an explanation how to obtain such data from the matlab graph
Family size and intergenerational social mobility during the fertility transition
No full textIt has been argued in sociology, economics, and evolutionary anthropology that family size limitation enhances the intergenerational upward mobility chances in modernized societies. If parents have a large flock, family resources get diluted and intergenerational mobility is bound to head downwards. Yet, the empirical record supporting this resource dilution hypothesis is limited. This article investigates the empirical association between family size limitation and intergenerational mobility in an urban, late nineteenth century population in Western Europe. It uses life course data from the Belgian city of Antwerp between 1846 and 1920. Findings are consistent with the resource dilution hypothesis: after controlling for confounding factors, people with many children were more likely to end up in the lower classes. Yet, family size limitation was effective as a defensive rather than an offensive strategy: it prevented the next generation from going down rather than helping them to climb up the social ladder. Also, family size appears to have been particularly relevant for the middle classes. Implications for demographic transition theory are discussed.Belgium, demographic transition, fertility, nineteenth century, parental investment, quantity-quality trade-off, resource dilution, social mobility
Role of Transglutaminase 2 in vascular remodeling
No full textVerschillende vasculaire ziektebeelden, waaronder hoge bloeddruk en verminderde doorbloeding, leiden tot vernauwing van slagadertjes. Het enzym Transglutaminase 2 (TG2) speelt hierbij een belangrijke rol. Jeroen van den Akker onderzocht het achterliggende proces en ontdekte een nieuwe activatieroute voor TG2. Ook vond hij de manier waarop vasculaire cellen vermoedelijk TG2 uitscheiden. Onderdrukking van TG2-activiteit in de vaatwand kan een basis zijn voor nieuwe cardiovasculaire geneesmiddelen
Second birth rates across Europe: interactions between women’s level of education and child care enrolment
No full textFertility differences in Europe are to a large extent due to parity progression after the first child. We therefore use data from the third round of the European Social Survey to investigate second-birth rates in 23 countries. Focusing on the role of education level and child care availability, we argue that child care provision is an important determinant of the opportunity cost of parity progression, particularly for highly educated women. We find that in countries where the highly educated have lower second birth rates than the less educated, total fertility tends to be low, and vice versa. In addition, the effect of the timing of the first child appears to be mediated by education level and child care availability: in countries where large proportions of young children attend formal child care, the more highly educated exhibit much higher second-birth rates, while child care availability does not affect parity progression for the less educated.
WSO909632 Supplemental Material2 - Supplemental material for qTICI: Quantitative assessment of brain tissue reperfusion on digital subtraction angiograms of acute ischemic stroke patients
No full textSupplemental material, WSO909632 Supplemental Material2 for qTICI: Quantitative assessment of brain tissue reperfusion on digital subtraction angiograms of acute ischemic stroke patients by Haryadi Prasetya, Lucas A Ramos, Thabiso Epema, Kilian M Treurniet, Bart J Emmer, Ido R van den Wijngaard, Guang Zhang, Manon Kappelhof, Olvert A Berkhemer, Albert J Yoo, Yvo BEWM Roos, Robert J van Oostenbrugge, Diederik WJ Dippel, Wim H van Zwam, Aad van der Lugt, Bas AJM de Mol, Charles BLM Majoie, Ed van Bavel, Henk A Marquering and on behalf of the MR CLEAN Registry Investigators in International Journal of Stroke</p
WSO909632 Supplemental Material1 - Supplemental material for qTICI: Quantitative assessment of brain tissue reperfusion on digital subtraction angiograms of acute ischemic stroke patients
No full textSupplemental material, WSO909632 Supplemental Material1 for qTICI: Quantitative assessment of brain tissue reperfusion on digital subtraction angiograms of acute ischemic stroke patients by Haryadi Prasetya, Lucas A Ramos, Thabiso Epema, Kilian M Treurniet, Bart J Emmer, Ido R van den Wijngaard, Guang Zhang, Manon Kappelhof, Olvert A Berkhemer, Albert J Yoo, Yvo BEWM Roos, Robert J van Oostenbrugge, Diederik WJ Dippel, Wim H van Zwam, Aad van der Lugt, Bas AJM de Mol, Charles BLM Majoie, Ed van Bavel, Henk A Marquering and on behalf of the MR CLEAN Registry Investigators in International Journal of Stroke</p
Organohalogen chemicals in human blood from the United Kingdom.
No full textBlood serum from 154 volunteers at 13 UK locations in 2003 were analysed for a range of PCBs, organochlorine pesticides and PBDEs. HCB, p,p′-DDE and p,p′-DDT and β-HCH were the dominant organochlorine pesticides in most samples. BDEs 47, 99, 100, 153, 154 and 183 were the most regularly detected PBDEs. This study is the first report of BDE209 in UK human blood (found in 11 samples, range <15–240 ng/g lipid). Concentration and age correlated for the less easily metabolised PCBs, p,p′-DDT and p,p′-DDE, HCB and HCHs. With increasing age females tended to have lower concentrations of the more chlorinated PCBs than males. Similar PBDE concentrations, and distributions, to those reported in the general population in Sweden in 2002 were found, despite differences in historical PBDE production and usage. There is increasing regulation to control persistent and bioaccumulative chemicals, and establishing human exposure will help to identify substances which should be urgently phased out. A survey of PBDE, PCB and OC pesticide concentrations in human blood helps identify baseline concentrations in the UK population and found decabromodiphenyl ether in non-occupationally exposed individuals
Inflammation and transglutaminases in vascular remodeling and atherosclerosis
No full textAtherosclerose (aderverkalking) ontstaat door een ingewikkeld samenspel van risicofactoren en lokale omstandigheden in de bloedvaten. Hanke Matlung bestudeerde deze omstandigheden met experimentele modellen en menselijk weefsel. Zij vond relaties tussen het stromingsprofiel van het bloed, interactie van witte bloedcellen met de vaatwand, en het risico op atherosclerose en kwetsbare plaques. Een cruciale factor hierin was het enzym transglutaminase, dat een rol speelt in zowel de interactie van leukocyten met de vaatwand als in calcificatie. Dit biedt aanknopingspunten voor toekomstige behandeling
The MediAct application: Stimulating patient healing in the patient room at the Radboudumc
No full textThe goal of this thesis is "to improve the wellbeing and healing of patients in their patient room at the Radboudumc by applying a healing environment that can be personalized".Industrial Design EngineeringIndustrial Desig
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