182,474 research outputs found
An enzymatic mechanism for calcium current inactivation in dialysed Helix neurones
No full text'Wash-out' and inactivation of the Ca current were examined in dialysed, voltage-clamped neurones of Helix aspersa under conditions that isolate the Ca current virtually free of other currents. EGTA or other internal Ca2+ chelators were routinely omitted from the dialysate. The time-dependent loss, or wash-out, of Ca current was slowed by addition to the dialysing solution of agents, such as dibutyryl adenosine 3'-5'-cyclic monophosphate (dibutyryl cyclic AMP), Mg adenosine 5'-triphosphate (ATP) and the catalytic subunit of cyclic-AMP-dependent protein kinase, that promote protein phosphorylation and by EGTA. However, neither the phosphorylation-promoting agents nor internal EGTA prevented wash-out entirely, nor did they significantly restore previously 'washed-out' current. With phosphorylating agents in the dialysing solution, the irreversible development of wash-out was greatly reduced by introduction of leupeptin, an inhibitor of protease activity. Thus, the irreversible component of wash-out appears to result from a Ca-dependent proteolytic process. In the presence of leupeptin alone, Ca current amplitude continued to decline: however, the current could be largely or fully restored with addition of catalytic subunit, dibutyryl cyclic AMP, and Mg ATP to the dialysing solution. Thus, inhibition of proteolysis revealed a reversible component of wash-out that appears to result from dephosphorylation. During perfusion with leupeptin, Mg ATP, dibutyryl cyclic AMP and catalytic subunit the Ca current remained stable for up to several hours without addition of internal Ca2+ buffer. The rate of inactivation of the current that occurs during a depolarizing step showed only a very gradual decline during this time. Under these conditions, perfusion with calcineurin, a Ca-calmodulin-dependent phosphatase, caused a significant increase in the rate of Ca current inactivation. This inactivation was virtually eliminated by introduction of EGTA or by replacement of external Ca2+ with Ba2+, which is consistent with the ion dependency for calmodulin-dependent activation of calcineurin. When ATP in the dialysate was replaced with ATP-gamma-S (adenosine 5'-O-(thiotriphosphate], an analogue that donates a thiophosphate group resistant to hydrolysis, the rate of inactivation slowed. Since Ca-dependent inactivation during step depolarizations is enhanced by conditions that promote dephosphorylation, and Ca current wash-out is slowed by conditions that promote phosphorylation, inactivation and reversible wash-out appear to be related
Leipziger Messe, Alljährlich im Frühjahr und Herbst, Auskunft durch den Mess-Ausschuss der Handelskammer Leipzig, Richard Eckert & Co., R.-G., Rudolstadt - Volkstedt, Luxus-Porzellanfabrik, Zur Messe in Leipzig, Kaufhaus 144
No full textLEIPZIGER MESSE, ALLJÄHRLICH IM FRÜHJAHR UND HERBST, AUSKUNFT DURCH DEN MESS-AUSSCHUSS DER HANDELSKAMMER LEIPZIG, RICHARD ECKERT & CO., R.-G., RUDOLSTADT - VOLKSTEDT, LUXUS-PORZELLANFABRIK, ZUR MESSE IN LEIPZIG, KAUFHAUS 144
Leipziger Messe, Alljährlich im Frühjahr und Herbst, Auskunft durch den Mess-Ausschuss der Handelskammer Leipzig, Richard Eckert & Co., R.-G., Rudolstadt - Volkstedt, Luxus-Porzellanfabrik, Zur Messe in Leipzig, Kaufhaus 144 ( -
sj-R-2-jom-10.1177_01492063221085913 - Supplemental material for Addressing Endogeneity Without Instrumental Variables: An Evaluation of the Gaussian Copula Approach for Management Research
No full textSupplemental material, sj-R-2-jom-10.1177_01492063221085913 for Addressing Endogeneity Without Instrumental Variables: An Evaluation of the Gaussian Copula Approach for Management Research by Christine Eckert and Jan Hohberger in Journal of Management</p
sj-R-3-jom-10.1177_01492063221085913 - Supplemental material for Addressing Endogeneity Without Instrumental Variables: An Evaluation of the Gaussian Copula Approach for Management Research
No full textSupplemental material, sj-R-3-jom-10.1177_01492063221085913 for Addressing Endogeneity Without Instrumental Variables: An Evaluation of the Gaussian Copula Approach for Management Research by Christine Eckert and Jan Hohberger in Journal of Management</p
Review of Style and Sociolinguistic Variation by Penelope Eckert and John R. Rickford
No full textReview of Style and Sociolinguistic Variation by Penelope Eckert and John R. Rickford
"Nicht Hitler tötet diese Leute allein, viele Deutsche töten sie." Die Behandlung nationalsozialistischer Herrschaft in Orientierungskursen - ein Werkstattbericht
No full textKorneli K. "Nicht Hitler tötet diese Leute allein, viele Deutsche töten sie." Die Behandlung nationalsozialistischer Herrschaft in Orientierungskursen - ein Werkstattbericht. In: Kenkmann A, Liepach M, Sadowski D, Leibniz-Institut für Bildungsmedien | Georg-Eckert-Institut, eds. Integration durch Geschichte? Werkstattberichte und Analysen zu den Orientierungskursen für Zugewanderte und Geflüchtete. Eckert. Expertise. Vol 11. Göttingen: V&R unipress; 2023: 117-138
Nishino, Ryota (2011): Changing histories. Japanese and South African textbooks in comparison, 1945–1995 (=Eckert. Die Schriftenreihe. Studien des Georg-Eckert-Instituts zur internationalen Bildungsforschung, Bd. 129), V & R unipress, Göttingen, 222 S. [Rezension]
No full textRezension von: Nishino, Ryota (2011): Changing Histories. Japanese and South African Textbooks in Comparison, 1945–1995 (=Eckert. Die Schriftenreihe. Studien des Georg-Eckert-Instituts zur internationalen Bildungsforschung, Bd. 129), V & R unipress, Göttingen, 222 S., ISBN 978-3-89971-816-
Brune R., Eckert D. et Kolossov V., Atlas de la Russie et des pays proches
No full textRadvanyi Jean. Brune R., Eckert D. et Kolossov V., Atlas de la Russie et des pays proches. In: Annales de Géographie, t. 105, n°590, 1996. pp. 423-424
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