55 research outputs found
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No full textDetecting pathogens and mounting immune responses upon infection is crucial for animal health. However, these responses come at a high metabolic price (McKean and Lazzaro, 2011, Kominsky et al., 2010), and avoiding pathogens before infection may be advantageous. The bacterial endotoxins lipopolysaccharides (LPS) are important immune system infection cues (Abbas et al., 2014), but it remains unknown whether animals possess sensory mechanisms to detect them prior to infection. Here we show that Drosophila melanogaster display strong aversive responses to LPS and that gustatory neurons expressing Gr66a bitter receptors mediate avoidance of LPS in feeding and egg laying assays. We found the expression of the chemosensory cation channel dTRPA1 in these cells to be necessary and sufficient for LPS avoidance. Furthermore, LPS stimulates Drosophila neurons in a TRPA1-dependent manner and activates exogenous dTRPA1 channels in human cells. Our findings demonstrate that flies detect bacterial endotoxins via a gustatory pathway through TRPA1 activation as conserved molecular mechanism.sponsorship: Vlaams Instituut voor Biotechnologie Alessia Soldano Luis Franco Guangda Liu Natalia Mora Emre Yaksi Bassem A Hassanr Fonds Wetenschappelijk Onderzoek G.0702.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0077.15 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0680.10 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0681.10 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0503.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0654.15 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0761.10N Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0596.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0565.07 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar KU Leuven GOA/14/011 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar European Commission IUAP P7/13 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekensr KU Leuven OT/12/091 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar KU Leuven PF-TRPLe Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talavera (Vlaams Instituut voor Biotechnologie, Fonds Wetenschappelijk Onderzoek|G.0702.12, Fonds Wetenschappelijk Onderzoek|G.0077.15, Fonds Wetenschappelijk Onderzoek|G.0680.10, Fonds Wetenschappelijk Onderzoek|G.0681.10, Fonds Wetenschappelijk Onderzoek|G.0503.12, Fonds Wetenschappelijk Onderzoek|G.0654.15, Fonds Wetenschappelijk Onderzoek|G.0761.10N, Fonds Wetenschappelijk Onderzoek|G.0596.12, KU Leuven|GOA/14/011, KU Leuven|OT/12/091, European Commission|IUAP P7/13, KU Leuven PF-TRPLe)status: Publishe
UvA-DARE (Digital Academic Repository) Redistribution of Longevity Risk: The effect of heterogeneous mortality beliefs *
No full textRedistribution of longevity risk: The effect of heterogeneous mortality beliefs Boonen, T.J.; De Waegenaere, A.; Norde, H. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Abstract Existing literature regarding the natural hedge potential that arises from combining different longevity-linked liabilities typically does not address the question how changes in the liability mix can be obtained. We consider firms who aim to exploit the benefits of natural hedge potential by redistributing their risks, and characterize the risk redistributions that will arise when the parties bargain for a redistribution of risk that weakly benefits them all. We analyze the effects of heterogeneity in the beliefs regarding the probability distribution of future mortality rates on the properties of these risk redistributions, and provide a numerical illustration for a case where an insurer with a portfolio of term assurance contracts and a pension fund with a portfolio of life annuities redistribute their risks. JEL-Classification: C71, C78, G22, J1
Economische evaluatie; g-groep ontwerp
No full textDocument uit de collectie Chemische ProcestechnologieDelftChemTechApplied Science
Display Repair: Battling Premature Obsolescence in Smartphones by Stimulating Repair Actions
No full textWith over 6 billion smartphones in use worldwide, high emissions and a considerable amount of e-waste, there is a need for a more sustainable approach. One such an approach is prolonging the use-times of smartphones, and for that repair should be popularised. This thesis examines how to prolong the use-time of smartphones through stimulating repair actions. The most occurring defect is to the display, while using the smartphone for one more year after a display repair saves about 20 percent in greenhouse gas emissions. For users to choose repair over replacement, repair needs to be affordable, accessible, and attractive, which current repair options do not adequately deliver. Smartphones can also be designed more reliable and repairable to support repairs and prolong use-times. These strategies need to be balanced with the smartphone’s competitiveness for a sizeable impact.Therefore, a repair platform is proposed for stimulating repair, alongside a repairable smartphone that aims at further triggering repair actions and competing with high-end smartphones for a sizeable impact. A collaboration between repair shops and manufacturers needs to deliver value to the user. The proposed system delivers accessibility by creating a repair network of independent shops, which gains user trust by offering original parts and warranty. It makes repair more attractive by reducing the time and effort it takes and giving users insight into their environmental contribution. This creates value for repair shops by delivering customers and enabling quicker turnaround times. The manufacturer benefits by receiving the old parts, being more in control of their supply chain and gaining a strengthened competitive positioning. By being more accessible and attractive, users are more motivated to repair. Affordability is the third factor necessary for favourable repair yet this is only achieved in part by quicker repair times. It needs to be further investigated how to reduce the costs of spare parts. This thesis contributes by combining the need for a repair network with repairable smartphones. A repair network needs more repairable smartphones, and a repairable smartphone needs a well-functioning repair network.Double degree in Integrated Product Design and Strategic Product DesignStrategic Product DesignIntegrated Product Desig
Feasibility Study on Optically Transparent Cylindrical Dielectric Resonator Antennas Integrated in an Enclosed Light Bulb Using Doppler Based Radar for Human Presence Detection
No full textThis thesis will focus on an 24 GHz indoor human presence detection radar with an optically transparent dielectric resonator antenna (DRA) applied in an enclosed light source. The DRA was studied extensively by simulations and measurements and demonstrated to suffer from blind spots for radar implementation because of the light bulb housing. To apply a DRA for the presence detection, one should do measurements on the radiation patterns of the DRA to match the DRA to its housing environment. A Frequency Modulated Continuous Wave (FMCW) radar was studied because of its possibility to detect almost static and moving humans.Simple waveforms such as the ramp and triangular waveform are used to obtain a beat frequency for presence detection. To linearize and remove the temperature and chip sample dependence of the BGT24MTR11 radar transceiver, a phase locked loop (PLL) was used based on the ADF4159 chip. The PLL was designed to have a loop bandwidth above 200 kHz and phase margin above 70 degrees, to reduce the frequency overshoot and have a relative fast lock. The system was tested and generated sweeps successfully for slow ramps, but failed on operating in the proper sweep bandwidth for ramps faster than 10 ms. The limitation on sweep time, lower transmit power and lossy circuitry were factors which made the radar system not suitable for human motion detection.Electrical Engineering | Telecommunications and Sensing System
At the Outer Limits of Democratic Division: On Citizenship, Conflict and Violence in the Work of Chantal Mouffe and Étienne Balibar
No full textsponsorship: This article is partially based on an earlier version of argument in Tijdschrift voor Filosofie (under the title `De Uiterste Limieten van de Democratische Verdeeldheid: Grenzen aan het Conflict in de Radical Democratie'). The author would like to thank Tijdschrift voor Filosofie for the permission to translate earlier arguments and Toon Braeckman and Matthias Lievens for comments and discussion. The research was funded by a grant from the Research Foundation Flanders. (Research Foundation Flanders)status: Published onlin
Effects of physical exercise and body weight on disease-specific outcomes of people with rheumatic and musculoskeletal diseases (rmds): systematic reviews and meta-analyses informing the 2021 eular recommendations for lifestyle improvements in people with
No full textThis work was funded by the European League Against Rheumatism.
SMMV and JMG are supported by Versus Arthritis (grant number 21755) and the
NIHR Manchester Biomedical Research Centre. The views expressed are those of
the author(s) and not necessarily those of the NHS, the NIHR or the Department of
Health.Gwinnutt J.M., Wieczorek M., Cavalli G., Balanescu A., Bischoff-Ferrari H.A., Boonen A., De Souza S., De Thurah A., Dorner T.E., Moe R.H., Putrik P., Rodríguez-Carrio J., Silva-Fernández L., Stamm T., Walker-Bone K., Welling J., Zlatković-Švenda M.I., Guillemin F., Verstappen S.M.M
IOF position statement: Vitamin D recommendations for older adults
No full textThis position paper of the International Osteoporosis Foundation makes recommendations for vitamin D nutrition in elderly men and women from an evidence-based perspective. © International Osteoporosis Foundation and National Osteoporosis Foundation 2010.Bischoff-Ferrari HA, 2009, BRIT MED J, V339, DOI 10.1136-bmj.b3692; Bischoff-Ferrari HA, 2005, JAMA-J AM MED ASSOC, V293, P2257, DOI 10.1001-jama.293.18.2257; Blum M, 2008, J AM COLL NUTR, V27, P274; Boonen S, 2007, J CLIN ENDOCR METAB, V92, P1415, DOI 10.1210-jc.2006-1404; DURAZOARVIZU RA, 2010, J NUTR, DOI DOI 10.3945-JM.109.116681; Flicker L, 2005, J AM GERIATR SOC, V53, P1881, DOI 10.1111-j.1532-5415.2005.00468.x; Fuleihan GEH, 2009, CLIN REV BONE MINER, V7, P77; Goussous R, 2005, J CLIN ENDOCR METAB, V90, P707, DOI 10.1210-jc.2004-1380; Harris SS, 2002, J AM COLL NUTR, V21, P357; Harris SS, 1998, J AM COLL NUTR, V17, P282; Heaney RP, 2003, AM J CLIN NUTR, V77, P204; Holick MF, 2008, J CLIN ENDOCR METAB, V93, P677, DOI 10.1210-jc.2007-2308; Mithal A, 2009, OSTEOPOROSIS INT, V20, P1807, DOI 10.1007-s00198-009-0954-6; OOMS ME, 1995, J CLIN ENDOCR METAB, V80, P1052, DOI 10.1210-jc.80.4.1052; Trang HM, 1998, AM J CLIN NUTR, V68, P854; Visser M, 2003, J CLIN ENDOCR METAB, V88, P5766, DOI 10.1210-jc.2003-030604; Wortsman J, 2000, AM J CLIN NUTR, V72, P690; Wortsman J, 2003, AM J CLIN NUTR, V77, P134217018816
Tertiary Control of Hybrid Tugboats: Fuel savings assessment with equivalent consumption minimization strategy
No full textSeverity of Diabetes Mellitus and Total Hip or Knee Replacement
No full textPermissions RESEARCH ARTICLE: OBSERVATIONAL STUDY Severity of Diabetes Mellitus and Total Hip or Knee Replacement A Population-Based Case–Control Study Nielen, Johannes T.H. MSc; Emans, Pieter J. PhD; Dagnelie, Pieter C. PhD; Boonen, Annelies PhD; Lalmohamed, Arief PhD; de Boer, Anthonius PhD; van den Bemt, Bart J.F. PhD; de Vries, Frank PhD Editor(s): Roever., Leonardo Author Information Medicine 95(20):p e3739, May 2016. | DOI: 10.1097/MD.0000000000003739 OPEN SDC Metrics Abstract It is generally thought that people with diabetes mellitus (DM) are more likely to suffer from osteoarthritis (OA) due to an increased body mass index (BMI), resulting in mechanical destruction of cartilage. However, previous studies have suggested a coexisting metabolic causality. To evaluate the risk of hip or knee replacement, as a proxy for severe OA, in patients with DM. We additionally evaluated the risk of total joint replacement (TJR) with various proxies for increased DM severity. A population-based case–control study was performed, using the Clinical Practice Research Datalink (CPRD). Cases (n = 94,609) were defined as patients >18 years who had undergone TJR between 2000 and 2012. Controls were matched by age, gender, and general practice. Conditional logistic regression was used to estimate the risk of total knee (TKR) and total hip replacement (THR) surgery associated with use of antidiabetic drugs (ADs). We additionally stratified current AD users by proxies for DM severity. Current AD use was significantly associated with a lower risk of TKR (OR = 0.86 (95% CI = 0.78–0.94)) and THR (OR = 0.90 (95% CI = 0.82–0.99)) compared to patients not using ADs. Moreover, risk of TKR and THR was decreased with increasing HbA1c. This study does not support the theory that DM patients are more likely to suffer from severe OA as compared to patients without diabetes. Moreover, risk of severe OA necessitating TJR decreases with increasing DM severity. This is possibly due to dissimilarities in methodology, a decrease in eligibility for surgery, or variability of OA phenotypes
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