1,720,958 research outputs found
Reliability of oupatient endometrial brush cytology vs biopsy in postmenopausal symptomatic women
No full textObjective To compare outpatient endometrial sampling cytology with conventional biopsy in postmenopausal women with abnormal uterine bleeding and/or abnormal endometrial thickness at ultrasound Method Between December 2003 and December 2009 a group of 1 056 postmenopausal women was referred to the Department of Gynecological Sciences Perinatology an Child Health 11 Faculty of Medicine University of Rome S Andrea Hospital Four hundred and eighty two patients (45 6%) had abnormal uterine bleeding and 602 (57 0%) showed an endometrial thickness > 5 mm at ultrasound Patients on hormonal therapy (n = 194) including hormonal replacement therapy (HRT) or tamoxifen (TMX) were enrolled in the study Endometrial cytologic sampling was per formed using a brush device (EBC) while endometrial histological sampling was retrieved using a Novak curette Histologic evaluation showed a) malignant neoplasia b) atypical hyperplasia c) benign pathology d) normal or atrophic endometrium The following points were investigated a) failure in performing a procedure for cervical stenosis or pelvic pain b) nondiagnostic specimens c) diagnostic accuracy Results Evidence in score pain differences between brush and curette endometrial samples were observed 50% of patients undergoing brush cytology had lower pain scores (chi square = 288 33 p = 001) whereas 60% of patients undergoing endometrial biopsy had higher pain scores (chi square = 264 84 p = 001) The failure rate in performing procedures was 8 0% vs 4 1% and the results were statistically significant on the McNemar test respectively p = 01 and p = 001 A nondiagnostic specimen was obtained in 3 9% of cases by EBC and 103% of cases by the Novak curette (p = 001) Cytological evaluation had a sensitivity of 100% specificity of 99% positive and negative predictive value of 97% and 100% for diagnosing malignant neoplasia Cytology had high diagnostic accuracy for atypical hyperplasia sensitivity 100% specificity 99% positive and negative predictive value 83% and 100% respectively Conclusions EBC is a reliable well tolerated outpatient diagnostic tool for endometrial sampling in detecting early stage cancer in postmenopausal patients at high risk for endometrial cance
Effects of tamoxifen and estrogen replacement therapy on lipid metabolism and some other cardiovascular risk factors: A prospective study in hysterectomised women
No full textOral administration of lactoferrin increases hemoglobin and total serum iron in pregnant women.
No full textIron deficiency anemia (IDA) during pregnancy continues to be of world-wide concern. IDA is a risk factor for preterm delivery and subsequent low birth weight, and possibly for poor neonatal health. Iron supplementation in pregnancy is a widely recommended practice, yet intervention programs have met with many controversies. In our study, 300 women at different trimesters of pregnancy were enrolled in a trial of oral administration of ferrous sulfate (520 mg once a day) or 30% iron-saturated bovine lactoferrin (bLf) (100 mg twice a day). Pregnant women refusing treatment represented the control group. In this group hemoglobin and total serum iron values measured after 30 d without treatment decreased significantly, especially in women at 18-31 weeks of pregnancy. In contrast, after 30 d of oral administration of bLf, hemoglobin and total serum iron values increased and to a greater extent than those observed in women treated orally for 30 d with ferrous sulfate, independently of the trimester of pregnancy. Unlike ferrous sulfate, bLf did not result in any side effects. These findings lead us to hypothesize that lactoferrin could influence iron homeostasis directly or through other proteins involved in iron transport out of the intestinal cells into the blood
Microsurgery versus laparoscopy in distal tubal obstruction hysterosalpingographically or laparoscopically investigated
No full textTo compare pregnancy rates after laparotomic microsurgical or laparoscopic distal tuboplasty. Two hundred and twenty-four women with infertility due to distal tubal occlusion were randomized to be treated with either laparotomy or laparoscopy from 1987 to 2001 at the Institute of Gynaecology and Obstetrics, University of Rome, "La Sapienza". The results were evaluated taking into account the type of surgical approach, the severity of tubal damage and of adhesions. After a 24-month follow-up period, the overall pregnancy rate obtained with microsurgery was 43.7%, of which 33.3% were term pregnancies, 5.0% abortions, and 5.0% ectopic pregnancies. After laparoscopy, the overall pregnancy rate was 41.6%, of which 29.1% were term pregnancies, 8.3% abortions and 3.9% ectopic pregnancies. No significant differences was observed between the two groups in terms of fertility rate (chi-square 0.016, p = 0.9003). Laparotomy plus microsurgery and laparoscopy were equally effective in restoring fertility in women with comparable tubal damage. The severity of the damage is a critical factor for the results
Transcervical hysteroscopic myomectomy: long-term effects on abnormal uterine bleeding.
No full textTo evaluate the effectiveness of hysteroscopic myomectomy in the treatment of symptomatic submucous leiomyomas and long-term outcomes. A total of 107 patients with abnormal uterine bleeding (n = 84) and/or infertility (n = 23) were submitted to hysteroscopic resection. Main outcome measures: control of menorrhagia and reproductive outcome. Abnormal uterine bleeding was controlled in 68 out of 84 patients with one procedure; 15 needed a second procedure for incomplete resection. Five patients had menorrhagic pathology relapse. Among 23 patients with associated infertility pregnancy was achieved in eight cases, seven went to term and one miscarried; one patient needed a second procedure. The mean follow-up was 36 months (24-60). Three patients were lost at follow-up. Transcervical hysteroscopic resection of submucous myomas is effective for control of abnormal uterine bleeding. Further studies are needed to define the value of such procedure in the treatment of infertility. Short and long-term results are strictly correlated to the possibility of obtaining a complete resection, which is conditioned by degree (0, 1, 2) and number of myomas
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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