1,721,019 research outputs found
Pre- and post-dormitum epilepsies : idiopathic generalized epilepsies
No full textEpilepsy and sleep have a profound bidirectional influence. Idiopathic generalized epilepsy (IGE) comprises a fascinating group of syndromes that constitute nearly one-third of all epilepsies. These syndromes are genetically determined and affect otherwise normal people of both sexes and all races. IGE manifests with typical absences, myoclonic jerks, and generalized tonic-clonic seizures, alone or in varying combinations and severity. IGE syndromes are typically modulated by the sleep-wake cycle, and particularly by the sleep-wake transition process, both in terms of the occurrence of seizures and interictal epileptiform discharges (IED), with pronounced susceptibility to sleep deprivation. IGE analysis from the point of view of arousal modulation enhances the concept of a biological continuum existing among IGE syndromes. At the same time, this analysis broaches the problem of syndromic diagnosis and identification of the factors influencing the phenotypic expression of some epileptic phenomena over the course of life with potential bidirectional influences between epileptic manifestations and sleep-wake processes
OSAS in età prescolare: indicazioni terapeutiche ed efficacia clinica del trattamento con dispositivi elastodontici
No full textLe apnee ostruttive del sonno sono un problema relativamente comune in età pediatrica, soprattutto in età prescolare. La diagnosi e l’intervento precoce sono essenziali per una risoluzione completa del problema, evitando sequele. L’odontoiatra ha un ruolo chiave nell’approccio al paziente, che deve essere personalizzato e includere specialisti diversi. Si riportano di seguito i dati di uno studio riguardante l’efficacia del trattamento con dispositivi preformati in associazione alla riabilitazione miofunzionale in pazienti pediatrici con OSAS lieve.Obstructive sleep apnea is a quite common problem in children, especially in those younger than 6 years. Early diagnosis and therapy are of paramount importance to obtain a complete resolution and to avoid complications. The odontologist plays a key role in patient’s management: the approach should be tailored to the single individual and should include several different specialists. We report the results of a study evaluating the efficacy of preformed devices in association with a myofunctional rehabilitation in pediatric patients with mild OSAS
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Occipital Seizures and Visual Pseudohallucinations Associated With the Addition of Bupropion to Clozapine : a Case Report
No full textEpilepsy in adult patients with Down syndrome : a clinical-video EEG study
Full text linkPatients with Down syndrome are now living longer and the overall prevalence of epilepsy is increasing, however, full characterisation of epilepsy in adult age is still incomplete. We describe the electroclinical characteristics of epilepsy in 22 adult patients with Down syndrome (11 males, 11 females), with a mean age of 46 years (range: 28-64 years), followed at the Epilepsy Centre, San Paolo Hospital in Milan. Mean age at epilepsy onset was 36.8 years (range: 6-60 years). Nine out of 22 patients had focal epilepsy, while nine had late-onset myoclonic epilepsy. In four patients, epilepsy was unclassified. The EEG pattern of our patients was characterised by a progressive slowing of the background activity with sharp-and-slow waves with frontal predominance. In the patients diagnosed with late-onset myoclonic epilepsy, the EEGs showed generalised polyspike waves. Three subjects had an episode of myoclonic status epilepticus at the beginning or in the course of the disorder. After the first descriptions of late-onset myoclonic epilepsy by Genton and Paglia (1994), this is one of the largest patient cohorts reported. Our data confirm that epilepsy in adult patients with Down syndrome presents peculiar electroclinical characteristics which should be recognized early as prompt, effective treatment may be beneficial. [Published with video sequences]
EPILEPSY IN ADULT PATIENTS WITH DOWN SYNDROME
No full textEven if Down's syndrome is the major cause of genetic mental retardation, epilepsy is reported to have a greater prevalence in these patients than in general population, since they achieve older ages when the prevalence of epilepsy in this population ranges 46%. The aim of the present study is to describe the electroclinical characteristics of epilepsy in adult patients with Down's syndrome followed at the Epilepsy Center, San Paolo Hospital in Milan. Twenty adult patients with Down' s syndrome (10 males, 10 females), with a mean age 44.5 years (range: 28-64 years), were found. Mean age at epilepsy onset was 33 years (range: 6-60 years). Eleven out of 20 patients presented focal epilepsy, while 6 showed a Late-Onset Myoclonic Epilepsy (LOMEDS). The EEG pattern of our patients was characterized by a progressive slowing of the background activity and a prevalence of paroxysmal activities over the fronto-temporal regions. In the patients diagnosed as LOMEDS the EEGs showed generalized polyspike-waves. Nearly half of the patients (40%) suffered from drug-resistant epilepsy and 4 subjects presented an epileptic status at the beginning or in the course of the disease. Epilepsy in adult patients with Down's syndrome shows peculiar electro-clinical characteristics which should be early recognized, since as longevity of these patients is increasing, they could be encountered in clinical practice more frequently than currently acknowledged
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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