1,721,126 research outputs found
Disabilità e concessione dei presidi protesici. VErifica di una prassi operativa.
No full textGli autori criticano la procedura che impone alle pazienti operate al seno di accedere all'istituto dell'invalidità civile quale unica possibilità per ottenere l'assegnazione delle protesi mammari
Effetto di polimorfismi genetici coinvolti nel processo infiammatorio e nel danno ossidativo nella malattia di Alzheimer
No full textDott. ssa Eliana Venturelli Dottorato in Medicina Molecolare, Ciclo XIX TITOLO: Effetto di polimorfismi genetici coinvolti nel processo infiammatorio e nel danno ossidativo nella malattia di Alzheimer Alzheimer s Disease (AD) is a multifactorial disease caused by both genetic and environmental factors. The aim of this project was to carry out association studies, to detect significant differences in polymorphism frequency in molecules involved in AD pathogenesis, including Nitric Oxide Synthase (NOS) isoforms (NOS3 and NOS1) and IP-10 (CXCL10) gene between patients and age matched healthy controls. ApoE, NOS3 Glu298Asp and T-786C, NOS1 C276T, VNTR and G-84A, were determined by PCR-RFLP and IP-10 exons were sequenced. ApoE e4 allele, NOS3 wild type (Glu/Glu) genotype, NOS1 T/T genotype and VNTR short alleles have been demonstrated to act as a risk factor for AD. On the contrary NOS3 T-786C, NOS1 G-84A and IP-10 did not increase the risk to develop the pathology. In conclusion, our genetic analysis contributed to identify some susceptibility factors for AD. Future perspectives are represented by the possibility to carry out pharmacogenetic studies for identifying responders and non responders
Rehabilitation in COPD patients admitted for exacerbation
Full text linkRecovery of lung function is delayed up to 2 months following acute exacerbation (AE) of COPD patients. After AE, even with optimal medical therapy, it takes considerable time for COPD patients to recover to baseline ability to perform usual physical activity.Despite pulmonary rehabilitation (PR) has been so far considered a useful non-pharmacological therapy in stable COPD individuals, still few studies have examined the effect of rehabilitation during and/or early after AE.The present review updates the application of early PR and main physical therapies both during hospital acute care and following discharge of COPD patients undergoing exacerbation.Only recently, literature has shown feasibility and effectiveness of early PR in COPD patients undergoing AE. Notwithstanding, it clearly appears a treatment indicated just after or even during an acute episode in hospital.Future studies should be able to clarify the practical role and effects of a timely application of rehabilitation to acute COPD, as well as the preferred modalities, duration and techniques to apply in this condition
La Riabilitazione Respiratoria. In: Malattie dell'Apparato Respiratorio (eds. L.M.Fabbri, S.A.Marsico))
No full textNon disponibil
Isolation and characterization of a virulent Lactobacillus sanfranciscensis bacteriophage and its impact on microbial population in sourdough
No full textThirty-five sourdough samples used for sweet and salted Italian baked products were checked for the presence of a virus active on Lactobacillus sanfranciscensis species. One phage, named EV3, was isolated and its phenotypic and genotypic features were investigated. It belonged to the Siphoviridae family (morphotype B1); its life cycle at 25°C lasted 3 hours with a burst size of about 30 viral particles per infected cell. SDS-PAGE showed one major structural protein of 35 kDa and four minor proteins. The genome, approximately 32 kb long, was a double stranded linear DNA molecule with a pac-type system. Phage spreading into sourdough did not adversely affect acidification and volume increase of the dough neither lactobacilli counts; the propagation of viral particles showed to be hindered. This is the first report of the isolation of a L. sanfranciscensis phage
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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