72 research outputs found
Azzo VI d'Este († 1212) e le società cittadine dell'Italia nord-orientale: convergenze e divergenze di progetti politici fra XII e XIII secolo
No full textAnalisi della composizione sociale del partito sostenitore dei marchesi d'Este tra XII e XIII secol
Lead ammonium citrate acetate (LACA) prevents spontaneous apoptosis in primary adult rat hepatocytes in synthetic medium.
No full textLead ammonium citrate acetate (LACA) prevents spontaneous apoptosis in primary adult rat hepatocytes in synthetic medium
Investigations into mechanisms modulating proliferation, differentiation, and apoptosis in cultured liver, adrenal, skin, and bone cells
No full textThe intricate modulatory roles played by manifold hormones, growth factors, cytokines, extracellular calcium concentrations, intracellular second messengers, protein kinases, and nuclear poly(ADP-ribose) polymerase in proliferative, differentiative, and apoptotic processes have been the subject of investigations that were carried out by means of in vitro either primary or secondary/tertiary cultures of differentiated epithelial (hepatocytes, keratinocytes, and adrenocytes) and connective tissue cells (osteoblasts and fibroblasts) obtained from man and/or other mammalians. In most cases, an ad hoc model system, in which cells were floated on the top of the growth medium and, hence, could enjoy nearly normal respiratory exchanges, was used. Such a system increased cell viability and the ability of parenchymal epithelial cells to respond to extremely low concentrations of growth factors, hormones, and pharmaco-toxicological agents in a way conceivably very close to their behaviour in vivo
Lead ammonium citrate acetate (LACA) prevents spontaneous apoptosis of primary adult rat hepatocytes in synthetic medium
No full textLead ammonium citrate acetate (LACA) prevents spontaneous apoptosis of primary adult rat hepatocytes in synthetic mediu
Informe científico de investigador: Tognana, Sebastián Alberto (2016-2017)
No full textMi tarea de investigación en el Instituto de física de materiales Tandil (IFIMAT) consiste en el estudio experimental de polímeros, compuestos de matriz polimérica y mezclas. El objetivo del estudio es la formación e interacción de diferentes fases en estos materiales, ya sea polímero-refuerzo inerte, refuerzo metálico o polímero-polímero, y su influencia sobre las propiedades finales del material. Los materiales utilizados para la preparación de compuestos son epoxi con carga metálica en distintas geometrías y para la preparación de mezclas se utiliza epoxi con el polímero biodegradable semicristalino poli-3-hidroxibutirato (PHB). Las técnicas de investigación son desarrolladas en el instituto o se acceden mediante colaboración: microscopía óptica, técnica de medición de constantes elásticas mediante excitación por impulso, dispersión de rayos X de bajo ángulo, calorimetría, nanoindentación instrumentada entre las más usadas en los últimos años
Tissue engineering for total meniscal substitution : Animal study in sheep model
No full textObjective: The aim of the study was to investigate the use of a novel hyaluronic acid/polycaprolactone material for meniscal tissue engineering and to evaluate the tissue regeneration after the augmentation of the implant with expanded autologous chondrocytes. Two different surgical implantation techniques in a sheep model were evaluated. Methods: Twenty-four skeletally mature sheep were treated with total medial meniscus replacements, while two meniscectomies served as empty controls. The animals were divided into two groups: cell-free scaffold and scaffold seeded with autologous chondrocytes. Two different surgical techniques were compared: in 12 animals, the implant was sutured to the capsule and to the meniscal ligament; in the other 12 animals, also a transtibial fixation of the horns was used. The animals were euthanized after 4 months. The specimens were assessed by gross inspection and histology. Results: All implants showed excellent capsular ingrowth at the periphery. Macroscopically, no difference was observed between cell-seeded and cell-free groups. Better implant appearance and integrity was observed in the group without transosseous horns fixation. Using the latter implantation technique, lower joint degeneration was observed in the cell-seeded group with respect to cell-free implants. The histological analysis indicated cellular infiltration and vascularization throughout the implanted constructs. Cartilaginous tissue formation was significantly more frequent in the cell-seeded constructs. Conclusion: The current study supports the potential of a novel HYAFF/polycaprolactone scaffold for total meniscal substitution. Seeding of the scaffolds with autologous chondrocytes provides some benefit in the extent of fibrocartilaginous tissue repair
PTH1-34 induces the differentiation program in adult human keratinocytes cultured in MCDB 153 synthetic medium.
No full textPTH1-34 induces the differentiation program in adult human keratinocytes cultured in MCDB 153 synthetic medium
Il PTH1-34 induce il programma differenziativo in cheratinociti umani adulti coltivati in medium sintetico MCDB 153.
No full textIl PTH1-34 induce il programma differenziativo in cheratinociti umani adulti coltivati in medium sintetico MCDB 153
Investigations into the mechanisms controlling proliferation, differentiation, and apoptosis in hepatocytes, adrenocortical cells, keratinocytes, and osteoblasts cultured in vitro.
No full textInvestigations into the mechanisms controlling proliferation, differentiation, and apoptosis in hepatocytes, adrenocortical cells, keratinocytes, and osteoblasts cultured in vitro
PTH1-34 induces the differentiation program in adult human keratinocytes cultured in MCDB 153 medium.
No full textPTH1-34 induces the differentiation program in adult human keratinocytes cultured in MCDB 153 medium
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