1,720,987 research outputs found
Multiple extrauterine adenomyomas and uterus-like masses : case reports and review of the literature
No full textObjective: To describe two rare cases of multiple extrauterine adenomyomas, their clinical management, and their response to surgical and hormone therapy with GnRH agonist. Design: Case report and review of the English-language scientific literature. Setting: Cases presented in a tertiary health care academic institution. Patient(s): Two patients without urogenital malformations diagnosed with extrauterine adenomyoma, which is a benign tumor composed of smooth muscle and endometrium, typically originating within the uterus. Intervention(s): Surgical radical excision of adenomyomas followed by a long-term hormone therapy with GnRH agonist. Main Outcome Measure(s): Anatomical and clinical outcomes. Result(s): Surgical treatment followed by long-term GnRH agonist therapy appeared effective in keeping the disease stable. After a long-term follow-up of 10 and 4 years, the two patients are still asymptomatic and stable. Conclusion(s): Only 19 other cases of extrauterine adenomyomas are reported in the English-language scientific literature, and no cases of multiple masses are described until now. It is probable that these extrauterine adenomyomas arose from a metaplastic transformation of the subcelomic mesenchyme. Long-term GnRH agonist therapy after surgery appeared effective in keeping the disease stable
Creation of a neovagina in Rokitansky patients with a pelvic kidney : comparison of long-term results of the modified Vecchietti and McIndoe techniques
No full textObjective: To evaluate perioperative data and long-term results of Rokitansky patients with a pelvic kidney that underwent the McIndoe and modified Vecchietti procedures.
Design: Retrospective descriptive study.
Setting: A tertiary referral center for the study and treatment of Rokitansky syndrome.
Patient(s): Eleven patients with Rokitansky syndrome.
Intervention(s): Two and nine patients, respectively, underwent the McIndoe and Vecchietti modified techniques.
Main Outcome Measure(s): Anatomic success was defined as a neovagina >= 6 cm long allowing easy introduction of two fingers within 6 months postoperatively. Functional success was considered achieved when the patient reported satisfactory sexual intercourse starting from 6 months postoperatively.
Result(s): Surgery was performed with no complications in all I I patients. The mean duration of surgery was 190 +/- 14.1 minutes in the first group and 32 +/- 6.4 minutes in the second group. At 14 years of follow-up, both ;patients who underwent McIndoe vaginoplasty had a mean +/- SD length and width of 8.2 +/- 0.4 cm and 5 cm and negative Schiller's test 24 months postoperatively. At 4 years of follow-Lip, eight out of the nine patients who underwent the Vecchietti procedure (89%) had a mean +/- SD length and width of the neovagina of 7.4 +/- 0.6 cm and 4.2 +/- 0.5 cm and iodine-positive vaginal-type epithelium coating 100% of the neovagina 24 months postoperatively.
Conclusion(s): While appearing to be safe, effective, and with optimal functional results, the modified Vecchietti approach also seems to yield good anatomical and aesthetic results along with shorter surgical and hospitalization times
Double uterus with obstructed hemivagina and ipsilateral renal agenesis : pelvic anatomic variants in 87 cases
No full textSTUDY QUESTION What are the anatomic variants (and their frequencies) of double uterus, obstructed hemivagina and ipsilateral renal agenesis? SUMMARY ANSWER Most cases examined (72.4%) were of the classic anatomic variant of the Herlyn-Werner-Wunderlich syndrome (with didelphys uterus, obstructed hemivagina and ipsilateral renal agenesis) but the 27.6% of cases are of a rare variant of the syndrome (with uterus septum or cervical agenesis), showing relevant clinical and surgical implications. WHAT IS KNOWN ALREADY The extreme variability of anatomic structures involved in this syndrome (both uterus, cervico-vaginal and renal anomalies) is well known, even if a complete and uniform analysis of all its heterogeneous presentations in a large series is lacking. STUDY DESIGN, SIZE, DURATION This is a retrospective study with 87 patients referred to our third level referral center between 1981 and 2011. PARTICIPANTS/ MATERIALS, SETTING, METHODS We analyzed the laparoscopic and chart records of 87 women, who referred to our institute with double uterus, unilateral cervico-vaginal obstruction and ipsilateral renal anomalies.MAIN RESULTSSixty-three of 87 patients had the more classic variant of didelphys uterus with obstructed hemivagina; 10/87 patients had septate bicollis uterus with obstructed hemivagina; 9/87 patients had bicornuate bicollis uterus with obstructed hemivagina; 4/87 patients had didelphys uterus with unilateral cervical atresia; 1/87 patients had bicornuate uterus with one septate cervix and unilateral obstructed hemivagina.LIMITATIONSThis is a retrospective study with a long enrolling period (30 years). WIDER IMPLICATIONS OF THE FINDINGS New insights in the anatomic variants of this rare syndrome with their relevant surgical implications.STUDY FUNDING/COMPETING INTERESTNo specific funding was obtained for this study. None of the authors have any competing interests to declare
A uterovaginal septum and imperforate hymen with a double pyocolpos
No full textThe presence of both a uterovaginal septum and imperforate hymen is described in a young patient presenting with ongoing chronic pelvic pain and a double pyocolpos. Ultrasound and magnetic resonance imaging scans were performed. The patient underwent laparoscopic adesiolysis, hymenotomy with drainage of 200 mL of pus, and excision of a complete longitudinal vaginal septum. Over the past 5 years of regular follow-up examinations, the patient has always reported regular menstrual cycles and an absence of pelvic pai
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Preparation of basic prolineamide derivatives of GE2270 and GE2270-like antibiotics
No full textTitle compds. [I; R1 = H, alkyl, dialkylaminoalkylene; X = alkylene, alkylenecarbonyl; R2 = amino, 5-6 membered N-heterocyclyl; R1R2 = atoms to form a (substituted) 5-6 membered heterocyclic ring; W1 = Ph; W2 = OH; or W1, W2 both = Me; X1 = H, Me; X2 = H, Me, MeOCH2; when both W1, W2 = Me, then X1 = Me and X2 = H], were prepd. Thus, GE2270 factor A3 was condensed with H-Ser-Pro-NHCH2CH2NEt2 hydrochloride (prepn. given) using Et3N/DPPA in DMF and the condensation product in THF was treated with Burgess reagent in CH2Cl2 followed by Me2CHOH quench and reflux to give I; (R1 = H; XR2 = CH2CH2NEt2; W1 = Ph; W2 = OH; X1 = Me; X2 = MeOCH2). The latter showed a min. inhibitory concn. of 0.06 μg/mL against Staphylococcus aureus
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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