263 research outputs found
Impact of intracerebral neuro-Behcet's disease immunoglobulin injection to brain parenchyma histology and behavioral tests
No full textNovel poly(ε-caprolactone)/gelatin wound dressings prepared by emulsion electrospinning with controlled release capacity of Ketoprofen anti-inflammatory drug
No full text[EN] In the present study, a single and binary Ketoprofen-loaded mats of ultrathin fibers were developed by electrospinning and their physical properties and drug release capacity was analyzed. The single mat was prepared by solution electrospinning of poly(¿-caprolactone) (PCL) with Ketoprofen at a weight ratio of 5wt%. This Ketoprofen-containing PCL solution was also used as the oil phase in a 7:3 (wt/wt) emulsion with gelatin dissolved in acidified water. The resultant stable oil-in-water (O/W) emulsion of PCL-in-gelatin, also containing Ketoprofen at 5wt%, was electrospun to produce the binary mat. Cross-linking process was performed by means of glutaraldehyde vapor on the electrospun binary mat to prevent dissolution of the hydrophilic gelatin phase. The performed characterization indicated that Ketoprofen was successfully embedded in the single and binary electrospun mats, i.e. PCL and PCL/gelatin, and both mats showed high hydrophobicity but poor thermal resistance. In vitro release studies interestingly revealed that, in comparison to the single PCL electrospun mat, the binary PCL/gelatin mat significantly hindered Ketoprofen burst release and exhibited a sustained release capacity of the drug for up to 4days. In addition, the electrospun Ketoprofen-loaded mats showed enhanced attachment and proliferation of L929 mouse fibroblast cells, presenting the binary mat the highest cell growth yield due to its improved porosity. The here-developed electrospun materials clearly show a great deal of potential as novel wound dressings with an outstanding controlled capacity to release drugs.The authors would like to acknowledge the Spanish Ministry of Economy and Competitiveness (MINECO) project AGL2015-63855-C2-1-R for financial support. The authors would also like to thank the European Cooperation Science & Technology (COST) Action MP1206 for their Short Term Scientific Mission (STSM) at IATA-CSIC, Valencia, and the Academic Writing Advisory Center (AWAC) of Atilim University for English language revision.Basar, AO.; Castro, S.; Torres-Giner, S.; Lagaron, JM.; Turkoglu Sasmazel, H. (2017). Novel poly(e-caprolactone)/gelatin wound dressings prepared by emulsion electrospinning with controlled release capacity of Ketoprofen anti-inflammatory drug. Materials Science and Engineering C: Biomimetic materials, sensors and systems (Online). 81:459-468. https://doi.org/10.1016/j.msec.2017.08.025S4594688
Some Theorems and Examples of Cone Banach Spaces
No full textIn this paper, by defining a cone norm parallel to.parallel to(A) on E over itself which behaves like the absolute value norm on R, we construct examples of cone Banach spaces. Namely, we define the m-Euclidian cone normed space E-m, E-infinity and the space C-E(S) of continuous functions in cones, to generalize the Banach spaces R-m, l(infinity) and C [a, b], respectively. Some basic lemmas and theorems are also proved to help in the construction and in the proof of completeness of the above mentioned examples of cone normed spaces
Coefficient estimates for certain subclasses of analytic functions defined by new operator
No full textBu çalışma, 17-21 Haziran 2021 tarihleri arasında Montreal[Kanada]’da düzenlenen 4. International Conference of Mathematical Sciences (ICMS)’da bildiri olarak sunulmuştur.In this paper, we investigate certain subclasses of analytic functions defined by generalized differential operators involving binomial series. Also, we obtain coefficient estimates involving of the nonhomogeneous Cauchy-Euler differential equation of order r
Vitamin, sterol and fatty acid contents of some edible and medicinal plants from East and Southeast Anatolia (Turkey) [Doğu ve güneydoğu anadolu’da (Türkiye) yetişen bazı yenebilir ve tıbbi bitkilerin vitamin, sterol ve yağ asidi içerikleri]
No full textAchillea millefolium L., Crataegus monogyna subsp. monogyna Jacq., Rubus discolor L., Salvia multicaulis Vahl., Morus alba L. and Pistacia terebinthus L. plants are consumed for some medicinal or nutritional purposes. The chemical composition, vitamins, sterols and fatty acid contents of these plants were presented in this study. Vitamin and sterol contents were high in A. millefolium flowers in comparison to leaves and seed. Vitamins E, K, and total sterol levels in C. monogyna subsp. monogyna fruit were higher than leaves and flower. For R. discolor fruit; vitamin and sterol contents were higher than leaves, flower and unripe fruit. For S. multicaulis, vitamin content was higher in leaves and the sterol content was higher in seed than other extracts. ?-Tocopherol, vitamins K, D and total sterol levels in M. alba fruit were higher than leaves and unripe fruit. In P. terebinthus, retinol and ?-tocopherol levels were higher in leaves, vitamins D, K, sterol levels were higher in flower than other extracts. The present study indicates that these plants can be a good natural source of fatty acids, vitamins and sterols. This study is first report about the phytochemical properties of R. discolor, and S. multicaulis. © 2015, Turkish Pharmacists Association. All rights reserved
Antioxidant properties of rubus discolor l. extracts and protective effects of its flower extract against hydrogen peroxide-induced oxidative stress in wistar rats [Rubus discolor L. ekstrelerinin antioksidan özellikleri ve çiçek ekstresinin hidrojen peroksit-nedenli oksidatif stres Oluşturulmuş wistar sıçanlarda koruyucu etkileri]
No full textIn the present study, in vitro antioxidant activities of ethanol and water extracts of Rubus discolor L. leaves, flower, unripe and ripe fruits were investigated. Additionally, the antioxidant and protective properties of R. discolor flower (RD) water extract on some important biochemical parameters against hydrogen peroxide (HP)-induced oxidative stress in rats were determined. The phytochemical profiles and antioxidant properties (scavenging against DPPH•, ABTS•+, H2O2, O2-, metal chelating, inhibition of lipid peroxidation and reducing power) of extracts were determined by spectrophotometric methods and HPLC. The antioxidant potential of RD flower extract supplementations were evaluated by measuring total protein, glutathione (GSH), malondialdehyde (MDA), vitamin A and E, cholesterol, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) levels in various tissues. The flower extracts were the most active extracts for in vitro antioxidant assays. In HP administered groups, MDA level was increased, GSH and total protein levels were decreased. In RD treated group, these substances levels were protected. In RD plus HP treated group, SOD and GSH-Px levels were increased. These results show that RD flower extract have the protective effects against H2O2 via its free radical scavenging activity, and this extract affected the level of antioxidant enzymes, vitamin A and E, cholesterol, GSH, total protein and MDA. © 2015, Turkish Pharmacists Association. All rights reserved
Some fixed point results in complete generalized metric spaces
No full textThe Banach contraction principle is the most important result. This principle has many applications and some authors was interested in this principle in various metric spaces as Brianciari.
The author initiated the notion of the generalized metric space as a generalization of a metric space by replacing the triangle inequality by a more general inequality, for all pairwise distinct points of . As such, any metric space is a generalized metric space but the converse is not true. He proved the Banach fixed point theorem in such a space. Some authors proved different types of fixed point theorems by extending the Banach's result. Wardowski introduced a new contraction, which generalizes the Banach contraction. He using a mapping introduced a new type of contraction called -contraction and proved a new fixed point theorem concerning -contraction. In this paper, we have dealt with -contraction and -weak contraction in complete generalized metric spaces. We prove some results for -contraction and -weak contraction and we show that the existence and uniqueness of fixed point for satisfying -contraction and -weak contraction in complete generalized metric spaces. Some examples are supplied in order to support the useability of our results. The obtained result is an extension and a generalization of many existing results in the literature
Kinematics of active left-lateral faulting in SE Turkey from offset Pleistocene river gorges: improved constraint on the rate and history of relative motion between the Turkish and Arabian plates
No full textIn the Arabian Platform of SE Turkey abundant evidence exists of fluvial incision by c. 110 +/- 10 m since the late Early Pleistocene, starting in or around marine oxygen isotope stage 22 at 870 ka. This incision, which has accompanied regional surface uplift as the isostatic response to regional erosion, has progressively \u27locked\u27 rivers into their gorges in landscape that formerly had much lower relief. We use this effect to estimate 4.44 +/- 0.06 km of left-lateral slip on this time scale on the Golbasi-Turkoglu Fault, a segment of the East Anatolian Fault Zone, from offset river gorges, giving a slip rate of 5.10 +/- 0.07 mm a(-1). Piercing points indicate that this fault has slipped a total of 19 km, making its age 3.73 +/- 0.05 Ma. A total of 33 km of relative motion between the Turkish and Arabian plates is documented on this time scale in the vicinity of Golbasi, at an overall time-averaged rate of 8.85 +/- 0.12 mm a(-1), the estimated Euler vector for relative motion between these plates being 0.89 +/- 0.01 degrees Mal about 33.4 degrees N, 42.3 degrees E. This method can be readily applied to determine slip rates, time-averaged since the late Early Pleistocene, on other strike-slip fault zones worldwide
Guaianolides and lignans from the aerial parts of Centaurea ptosimopappa.
No full textThe genus Centaurea L. (Asteraceae, tribe Cardueae, subtribe Centaureinae) comprises ca. 600 species distributed in Asia, Europa, North Africa and America Hickey and King, 1981; Heywood, 1979). Turkish flora numbers 187 species, 114 of which being endemic (Davis, 1975; Davis et al., 1988; Wagenitz et al., 1988; Guner et al., 2000; Duran and Duman, 2000; Turkoglu et al., 2003).
Centaurea ptosimopappa Hayek is an endemic species distributed in the Mediterranean and South-Eastern Anato-
lian regions of Turkey; widespread and locally frequent in the Amanos and Casus mountains (Davis, 1975; Reeves and Adigu ̈zel, 2004). Aerial parts of C. ptosimopappa were collected in Hatay, the Amanos Mountain above Do ̈rtyol (Turkey), 850e950 m above sea level in June 2003 (36  510 N, 36  130 E). Voucher specimens (Celik 2148e2153) are deposited at the Department of Biology, C ̧anakkale Onsekiz Mart University
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