26,972 research outputs found
Intuizione e calcolo nella progettazione dell strutture. C - D PREVENZIONE DEI DISSESTI E CONSOLIDAMENTO (Cerone M. coll)
No full text(Cerone M coll) 450 p 24x31,5
Institutional repositories in New Zealand: comparing institutional strategies for digital preservation and discovery
No full textThis paper outlines an ongoing project to create of a knowledge base to support the development of institutional repositories in New Zealand. The knowledge base wiki includes a summary of key literature to date, highlighting best practice, and standards relevant to the New Zealand sector, and a set of case studies of how New Zealand institutions have developed their repositories to date. These case studies are analysed, and different strategic approaches taken by institutions across the sector identified. These will then be discussed in relation to the issues identified in the literature. The paper also outlines new research areas being developed by the research team, a national approach that will link individual institutional approaches with the goals of the New Zealand Digital Strategy, and incorporate a survey of the perceptions and responses of NZ academics, and other key stakeholders, that are critical to the success of both the national strategy and individual institutional initiatives
Conformational choreography of a molecular switch region in myelin basic protein—Molecular dynamics shows induced folding and secondary structure type conversion upon threonyl phosphorylation in both aqueous and membrane-associated environments
No full textAbstractThe 18.5kDa isoform of myelin basic protein is essential to maintaining the close apposition of myelin membranes in central nervous system myelin, but its intrinsic disorder (conformational dependence on environment), a variety of post-translational modifications, and a diversity of protein ligands (e.g., actin and tubulin) all indicate it to be multifunctional. We have performed molecular dynamics simulations of a conserved central segment of 18.5kDa myelin basic protein (residues Glu80–Gly103, murine sequence numbering) in aqueous and membrane-associated environments to ascertain the stability of constituent secondary structure elements (α-helix from Glu80–Val91 and extended poly-proline type II from Thr92–Gly103) and the effects of phosphorylation of residues Thr92 and Thr95, individually and together. In aqueous solution, all four forms of the peptide bent in the middle to form a hydrophobic cluster. The phosphorylated variants were stabilized further by electrostatic interactions and formation of β-structures, in agreement with previous spectroscopic data. In simulations performed with the peptide in association with a dimyristoylphosphatidylcholine bilayer, the amphipathic α-helical segment remained stable and membrane-associated, although the degree of penetration was less in the phosphorylated variants, and the tilt of the α-helix with respect to the plane of the membrane also changed significantly with the modifications. The extended segment adjacent to this α-helix represents a putative SH3-ligand and remained exposed to the cytoplasm (and thus accessible to binding partners). The results of these simulations demonstrate how this segment of the protein can act as a molecular switch: an amphipathic α-helical segment of the protein is membrane-associated and presents a subsequent proline-rich segment to the cytoplasm for interaction with other proteins. Phosphorylation of threonyl residues alters the degree of membrane penetration of the α-helix and the accessibility of the proline-rich ligand and can stabilize a β-bend. A bend in this region of 18.5kDa myelin basic protein suggests that the N- and C-termini of the proteins can interact with different leaflets of the myelin membrane and explain how a single protein can bring them close together
E. P. Ferguson, Snohomish, Washington, approximately 1893
No full textCaption on mount: F. Perry. Snohomish, Washington.
Handwritten on verso: E. P. Ferguson. Pioneer of Snohomish.
PH Coll 334 Perry.1Frank Perry was a photographer in Snohomish, Washington ca. 1893.To order a reproduction, inquire about permissions, or for information about prices see:
http://www.lib.washington.edu/specialcollections/services/reproduction/reproduction
Please cite the Order Numbe
Perspectivas de futuro en historia económica
No full textEditada en la Fundación Empresa PúblicaEste artículo explora posibles vías de evolución de la historia económica en un futuro próximo. El autor pasa revista a la trayectoria de la disciplina durante las últimas décadas, con especial atención a la influencia de la revolución cliométrica, y argumenta que la historia económica pasa actualmente por una situación crítica. Para salir de ella, aboga por una mayor atención al cambio tecnológico y al cambio institucional, como temas distintivos del largo plazo, estrechando la cooperación con la economía del desarrollo, la economía del crecimiento, la economía neoinstitucional, la economía de la empresa y la economía del cambio tecnológico.This article explores possible ways in which economic history may evolve in the foreseeable future. The author starts with a review of the evolution of the discipline in past decades, with especial attention to the influx of the cliometric revolution, and contends that the economic history is presently passing through a critical situation. To overcome it, the author makes a plea for increasing attention towards economic and institutional change, seen as topics distinctive of the long run, and for a rapprochement to development economics, growth economics, neo-institutional economics, firm theory and economics of technical change.Publicad
Sitting and Television Viewing Novel Risk Factors for Sleep Disturbance and Apnea Risk? Results from the 2013 National Sleep Foundation Sleep in America Poll
No full textBACKGROUND: Excess sitting is emerging as a novel risk factor for cardiovascular disease, diabetes, mental illness, and all-cause mortality. Physical activity, distinct from sitting, is associated with better sleep and lower risk for OSA, yet relationships among sitting behaviors and sleep/OSA remain unknown. We examined whether total sitting time and sitting while viewing television were associated with sleep duration and quality, OSA risk, and sleepiness.METHODS: the 2013 National Sleep Foundation Sleep in America Poll was a cross-sectional study of 1,000 adults aged 23 to 60 years. Total sitting time, time watching television while sitting, sleep duration and quality, OSA risk, and daytime sleepiness were assessed.RESULTS: After adjusting for confounding factors (including BMI and physical activity), each additional hour per day of total sitting was associated with greater odds of poor sleep quality (OR [95% CI] = 1.06 [1.01, 1.11]) but not with other sleep metrics (including sleep duration), OSA risk, or daytime sleepiness. for television viewing while sitting, each additional hour per day was associated with greater odds of long sleep onset latency (>= 30 min) (OR = 1.15 [1.04, 1.27]), waking up too early in the morning (OR = 1.12 [1.03, 1.23]), poor sleep quality (OR = 1.12 [1.02, 1.24]), and high risk for OSA (OR = 1.15 [1.04, 1.28]). Based upon an interaction analysis, regular physical activity was protective against OSA risk associated with television viewing (P = .04).CONCLUSIONS: Excess sitting was associated with relatively poor sleep quality. Sitting while watching television was associated with relatively poor sleep quality and OSA risk and may be an important risk factor for sleep disturbance and apnea risk.Arizona State Univ, Sch Nutr & Hlth Promot, Phoenix, AZ 85004 USAUniv Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USAArizona State Univ, Phoenix VA Hlth Care Syst, Coll Nursing & Hlth Innovat, Phoenix, AZ 85004 USAUniv Kentucky, Coll Med, Div Pulm Crit Care & Sleep Med, Lexington, KY USAUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, BrazilBaylor Coll Med, Sleep Ctr, Michael E DeBakey Vet Affairs Med Ctr, Houston, TX 77030 USABaylor Coll Med, Dept Med, Houston, TX 77030 USAUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, BrazilWeb of ScienceNational Sleep FoundationNational Institutes of HealthNational Institutes of Health: K23HL118318National Institutes of Health: R01HL09579
La réception de Vatican II, édité par G. Alberigo et J.-P. Jossua (coll. Cogitatio fidei, 134). 1985 Il Vaticano II e la Chiesa, a cura di G. Alberigo e J.-P. Jossua (coll. Biblioteca di cultura religiosa, 47). 1985
No full textThils Gustave. La réception de Vatican II, édité par G. Alberigo et J.-P. Jossua (coll. Cogitatio fidei, 134). 1985 Il Vaticano II e la Chiesa, a cura di G. Alberigo e J.-P. Jossua (coll. Biblioteca di cultura religiosa, 47). 1985. In: Revue théologique de Louvain, 18ᵉ année, fasc. 1, 1987. pp. 120-121
Norse settlement in the Inner Hebrides ca. 800-1300; with special reference to the islands of Mull, Coll and Tiree
No full textThe thesis aims to elucidate the form, extent and chronological
development of Norse colonial settlement in the Inner Hebridean islands of Mull, Coll,
Thee and Lismore in the period ca 800-1300. Tiree, Coll and Lismore are studied in
their entirety while an area from each of the parochial divisions on Mull is selected.
Historically Mull, Coll and Tiree have an essential territorial unity in
that they formed part of the territory of the cenel Loairn within the kingdom of Dalriada
in the pre-Norse period. With the division of the Isles in 1156 all three islands fell into
the hands of Somerled of Argyll and in the immediate post-Norse period remained as a
unit in the possession of the MacDougals.
Geographically the islands differ greatly from one another and show a
wide range of geological structures, landforms, soil types and vegetation, and climatic
conditions. They thus offer an opportunity for analysing settlement location,
development and expansion within a relatively small geographical area and yet one
which encompasses a variety of natural incentives and constraints. Lismore, lying to
the north-west of the above group and strategically situated at the mouth of the Great
Glen was important in the pre-Norse period as a major Celtic monastic centre. The
island is included by way of contrast, for its site and situation and close proximity to
mainland Scotland suggested that the Norse settlement of the island may have been of a
different character to that found on Mull, Coll and Tiree.
An area of the Norwegain 'homeland', the Sunnmore islands lying off
the west coast of Norway is looked at for comparative purposes. This allows an
investigation of the evolution of Norse settlement and the coining of names within a
purely Norse environment. This helps clarify the process of settlement development
and expansion and the accompanying naming practices in a colonial setting where,
particularly on Mull and Lismore, a dense Gaelic overlay often obscures salient features
of the Norse settlement pattern.
The methodology employed is both inter-disciplinary and retrospective
allowing successive layers of settlement to be 'peeled back' in order to expose the
pattern of settlement as it may have existed in the Norse period.
The thesis divides into two parts. The first analyses settlement by
settlement, the islands in question. The second concentrates on the major issues
pertinent to settlement evolution. Norse and Gaelic settlement names are discussed
together with the administrative and ecclesiastical organisation of the Isles. This leads to
the formulation of a 'model for Norse settlement' for the Inner Hebrides
P. Rollin. — Phytochrome, Photomorphogénèse et Photopériodisme, 1970. (Monographies de Physiologie Végétale, coll. dir. par le Pr P.-E. Pilet)
No full textJosserand Marcel. P. Rollin. — Phytochrome, Photomorphogénèse et Photopériodisme, 1970. (Monographies de Physiologie Végétale, coll. dir. par le Pr P.-E. Pilet). In: Bulletin mensuel de la Société linnéenne de Lyon, 40ᵉ année, n°4, avril 1971. p. 60
Lo screening neonatale della fibrosi cistica. Due metodi a confronto su 229.626 neonati esaminati in 8 anni nel Veneto.
No full textLo screening neonatale della fibrosi cistica. Due metodi a confronto su 229.626 neonati esaminati in 8 anni nel Veneto
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