401 research outputs found
Blood and stone on stage: Peter Shaffer's tragic plays /
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão.O objetivo específico desta tese é analisar quatro peças de autoria de Peter Shaffer-The Royal Hunt of the Sun, Equus, Amadeus e Yonadab-observando o uso de técnicas teatrais e a relação com os princípios da tragédia propostos por Aristóteles na Poética. Elas são então comparadas com três importantes peças gregas-Prometeu Acorrentado, de Ésquilo, Édipo Rei, de Sófocles e Medéia, de Eurípides- uma vez que o objetivo geral do presente trabalho é descobrir se existe tragédia moderna, de que forma ela é apresentada nas peças de Shaffer, e em que ela difere da tragédia grega. Na análise empreendida verifica-se que as peças de Shaffer apresentam muitas afinidades com as tragédias gregas e observam vários dos princípios estabelecidos por Aristóteles. No entanto elas se constituem em exemplares genuínos de tragédia moderna, pois discutem questões sérias atuais e apresentam personagens desafiadoras que enfrentam situações complexas e dilemas éticos e metafísicos. Além disso, as peças de Shaffer apresentam enredos muito bem elaborados, que combinam com habilidade os vários recursos teatrais descritos, e culminam numa experiência envolvente de teatro. No primeiro capítulo o paradigma teórico da tese é apresentado e analisado-os elementos e recursos teatrais e a Poética de Aristóteles-, mostrando como eles são importantes para o estudo do teatro em geral e para a tragédia em particular. No segundo capítulo os vários itens da fundamentação teórica são aplicados às peças gregas selecionadas, mostrando como elas confirmam e como se desviam dos princípios aristotélicos. No terceiro capítulo, o mesmo é feito em relação às peças de Peter Shaffer. No quarto capítulo as peças de Peter Shaffer são comparadas às gregas, mostrando como um dramaturgo moderno, através de narrativas históricas e míticas, recria o drama trágico, usando os vários recursos teatrais disponíveis para transmitir uma perspectiva trágica da vida. A Conclusão é que, considerando as semelhanças e diferenças detectadas entre as peças de Shaffer e as gregas, as peças de Shaffer podem ser consideradas tragédias modernas relevantes, que resgatam uma visão trágica da vida, tão importante para os gregos, num contexto moderno
Part 1. International Classification of Functioning, Disability and Health (ICF) Core Sets for persons with sleep disorders: results of the consensus process integrating evidence from preparatory studies
No full textBackground/objectives. The International Classification of Functioning, Disability and Health (ICF) provides a comprehensive and universally accepted framework to classify changes in functioning related to health conditions. Comprehensive and Brief Core Sets have been defined for various disorders but not for sleep disorders. Such a Core Set would greatly enhance the techniques available to describe the impact of sleep disorders on patients. The overarching purpose of this paper is to report on phase 1 of the international and World Health Organization (WHO) endorsed consensus process in identifying ICF Core Sets for sleep disorders.Methods. A formal decision-making and consensus process which integrated evidence gathered from preparatory studies was carried out. Relevant ICF categories were selected by a sample of international experts from different backgrounds using the nominal group technique.Results. Twenty-six experts from 22 countries and different professional backgrounds attended the consensus conference. Altogether 120 second- or third-level ICF categories were included in the Comprehensive ICF Core Set with the following ICF component split: 49 categories from body functions, 8 from body structures, 31 from activities and participation and 32 from environmental factors. The Brief ICF Core Set included a total of 15 second-level categories: 5 body functions (sleep, energy and drive, attention, consciousness, respiration functions); 3 body structures (brain, respiratory system, pharynx); 4 activities and participation (focusing attention, driving, handling stress and other psychological demands, carrying out daily routine); and 3 environmental factors (immediate family; health services, systems, and policies; and health professionals).Conclusion. A formal consensus process integrating evidence and expert opinion led to the first version of the ICF Core Sets for persons with sleep disorders. Further validation of the Core Set is needed
MSJ770019_supplementary_table_1 – Supplemental material for Deconstruction of <i>HLA-DRB1*04:01:01</i> and <i>HLA-DRB1*15:01:01</i> class II haplotypes using next-generation sequencing in European-Americans with multiple sclerosis
No full textSupplemental material, MSJ770019_supplementary_table_1 for Deconstruction of HLA-DRB1*04:01:01 and HLA-DRB1*15:01:01 class II haplotypes using next-generation sequencing in European-Americans with multiple sclerosis by Lisa E Creary, Kalyan C Mallempati, Sridevi Gangavarapu, Stacy J Caillier, Jorge R Oksenberg and Marcelo A Fernández-Viňa in Multiple Sclerosis Journal</p
MSJ770019_supplementary_table_2 – Supplemental material for Deconstruction of <i>HLA-DRB1*04:01:01</i> and <i>HLA-DRB1*15:01:01</i> class II haplotypes using next-generation sequencing in European-Americans with multiple sclerosis
No full textSupplemental material, MSJ770019_supplementary_table_2 for Deconstruction of HLA-DRB1*04:01:01 and HLA-DRB1*15:01:01 class II haplotypes using next-generation sequencing in European-Americans with multiple sclerosis by Lisa E Creary, Kalyan C Mallempati, Sridevi Gangavarapu, Stacy J Caillier, Jorge R Oksenberg and Marcelo A Fernández-Viňa in Multiple Sclerosis Journal</p
The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse
No full textAbstract Background The hematopoietic stem cells (HSCs) niche of the bone marrow is comprised of HSCs, osteoblasts, endothelial cells and a stromal component of non-hematopoietic multipotent cells of mesenchymal origin named "mesenchymal stem cells" (MSCs). Results Here we studied the global transcriptional profile of murine MSCs with immuno-therapeutic potential and compared it with that of 486 publicly available microarray datasets from 12 other mouse tissues or cell types. Principal component analysis and hierarchical clustering identified a unique pattern of gene expression capable of distinctively classifying MSCs from other tissues and cells. We then performed an analysis aimed to identify absolute and relative abundance of transcripts in all cell types. We found that the set of transcripts uniquely expressed by MSCs is enriched in transcription factors and components of the Wnt signaling pathway. The analysis of differentially expressed genes also identified a set of genes specifically involved in the HSC niche and is complemented by functional studies that confirm the findings. Interestingly, some of these genes play a role in the maintenance of HSCs in a quiescent state supporting their survival and preventing them from proliferating and differentiating. We also show that MSCs modulate T cell functions in vitro and, upon in vivo administration, ameliorate experimental autoimmune encephalomyelitis (EAE). Conclusion Altogether, these findings provide novel and important insights on the mechanisms of T cell function regulation by MSCs and help to cement the rationale for their application in the treatment of autoimmune diseases.</p
Philosophy’s Contribution Toward Learning Beyond Specialization
No full textThe relationship between education and philosophy has changed dramatically between ancient and contemporary eras. In ancient times, educated citizens were encouraged to practice philosophy. Today, excessive focus on specialization marginalizes philosophy into a specialized discipline significantly decreasing students’ development of philosophical capacities across curricula. Yet, developing philosophical capacities occurs beyond specialization. In this paper, I critique contemporary American higher education through a comparison of ancient Socratic and Confucian education by analyzing how philosophy’s role has changed and demonstrating why implementing philosophical development across curriculums in American higher education is practical, despite tensions between both traditional vs. progressive values and the development of technical skills for job placement vs. philosophical capacities.
Currently in American public higher education, philosophy and other disciplines within the humanities are classified as having less job-market value and are therefore treated as less practical mainly because of the highly specialized and market-driven education system. Yet disciplines with higher market values such as the science, technology, engineering, and mathematics (STEM) fields and other professional programs lack sufficient focus on developing and exercising philosophical capacities in their learning objectives, which require deliberate efforts beyond what specialized expertise or technical education offers alone. Philosophical capacities include analytical analysis, logical reasoning, decision making, identifying assumptions underlying methods and beliefs, sympathetic understanding, and adroit perspective shifting. The two primary conflicts that I investigate that contribute to philosophy’s devaluation in education include traditional vs. progressive values and developing practical skills for job placement vs. philosophical development (self-development). These two conflicts are perennial conflicts that have persisted throughout the ancient eras and continue to contribute to philosophy’s present state of isolation, distorting the social conception of philosophy and misrepresenting the nature and function of philosophy’s role in society and within education.
In recognizing the shift in philosophy’s role between ancient and contemporary times, I compare ancient Socratic and ancient Confucian educational approaches. In the comparison of these two ancient approaches, I demonstrate that the two conflicts that currently contribute to philosophy’s marginalization and devaluation were present in ancient times also. The purpose of showing that the two conflicts existed in the two ancient cultures is to demonstrate that historically, philosophical pedagogy had become a foundational component of educational approaches despite the presence of these two conflicts, while cultural traditions and practical skills remained generally intact. Furthermore, because the two conflicts existed in the two ancient cultures, I emphasize that the two conflicts that contribute to philosophy’s present state in academia are unjustifiable explanations for philosophy’s present state of marginalization; Both Socratic and Confucian approaches valued and implemented philosophical development within their education. Seeing that the ancient Confucian approach is relatively more traditional AND skill oriented in comparison to the ancient Socratic approach demonstrates that philosophy itself is not polarized one way or another, since both valued philosophical development and implemented it within their developmental practices.
The primary purpose of the comparison suggests that philosophy, as an activity or practice, can become integrated as a foundational component of American public higher education. By implementing philosophy into the foundations of American public higher education, students across all disciplines can encounter adequate philosophical development within their specialized fields, which can help us mediate the enduring value conflicts, rather than clinging to one extreme over the other
Common variants on chromosome 6p22.1 are associated with schizophrenia.
No full textSchizophrenia, a devastating psychiatric disorder, has a prevalence of 0.5-1%, with high heritability (80-85%) and complex transmission. Recent studies implicate rare, large, high-penetrance copy number variants in some cases, but the genes or biological mechanisms that underlie susceptibility are not known. Here we show that schizophrenia is significantly associated with single nucleotide polymorphisms (SNPs) in the extended major histocompatibility complex region on chromosome 6. We carried out a genome-wide association study of common SNPs in the Molecular Genetics of Schizophrenia (MGS) case-control sample, and then a meta-analysis of data from the MGS, International Schizophrenia Consortium and SGENE data sets. No MGS finding achieved genome-wide statistical significance. In the meta-analysis of European-ancestry subjects (8,008 cases, 19,077 controls), significant association with schizophrenia was observed in a region of linkage disequilibrium on chromosome 6p22.1 (P = 9.54 x 10(-9)). This region includes a histone gene cluster and several immunity-related genes--possibly implicating aetiological mechanisms involving chromatin modification, transcriptional regulation, autoimmunity and/or infection. These results demonstrate that common schizophrenia susceptibility alleles can be detected. The characterization of these signals will suggest important directions for research on susceptibility mechanisms
Sub-nanometer mapping of strain-induced band structure variations in planar nanowire core-shell heterostructures
No full textStrain relaxation mechanisms during epitaxial growth of core-shell nanostructures play a key role in determining their morphologies, crystal structure and properties. To unveil those mechanisms, we perform atomic-scale aberration-corrected scanning transmission electron microscopy studies on planar core-shell ZnSe@ZnTe nanowires on α-Al2O3 substrates. The core morphology affects the shell structure involving plane bending and the formation of low-angle polar boundaries. The origin of this phenomenon and its consequences on the electronic band structure are discussed. We further use monochromated valence electron energy-loss spectroscopy to obtain spatially resolved band-gap maps of the heterostructure with sub-nanometer spatial resolution. A decrease in band-gap energy at highly strained core-shell interfacial regions is found, along with a switch from direct to indirect band-gap. These findings represent an advance in the sub-nanometer-scale understanding of the interplay between structure and electronic properties associated with highly mismatched semiconductor heterostructures, especially with those related to the planar growth of heterostructured nanowire networks
Promotion of tolerance at the Christian lessons in junior primary school
No full textEvitas Šilovas pētījumā tiek analizēta kristīgā mācība kā iecietības veicinātāja
sākumskolā.
Pētījuma teorētiskajā daĜā, pamatojoties uz I. Plotnieka, G. Svences, I. Puškareva,
Dz. Meikšānes, V. V. Klīves, A. Milta, Ž. Piažē, A. Vorobjova, S. Lasmanes, A.
RubeĦa, D. Lieăenieces, A. Oksenberg Rorty atziĦām, darba autore analizē iecietības
jēdzienu, sākumskolas skolēnu vecumposma īpatnības.
Pētījuma empīriskajā daĜā darba autore analizē, kā kristīgā mācība veicina iecietību
skolēnu starpā sākumskolā. Šajā darba daĜā autore pielieto pētījuma metodes: strukturēto
interviju, dokumentu analīzi.
Pētījumu rezultātā, darba autore secina, ka kristīgā mācība veicina iecietību,
atklājot bērniem iecietības paraugu – Jēzu, par kura dzīvi tiek runāts kristīgajā mācībā.
Atslēgvārdi: iecietība, sākumskolas skolēns, kristīgā mācība, iecietības
veicināšana, dokumentu analīze, strukturētā intervija.In the research of Evita Šilova Christian lessons as means of promotion of tolerance
in the primary school are analyzed.
In the theoretical part of the research, which is based on the theory of I. Plotnieka,
G. Svences, I. Puškareva, Dz. Meikšānes, V. V. Klīves, A. Milta, Ž. Piažē, A.
Vorobjova, S. Lasmanes, A. RubeĦa, D. Lieăenieces, A. Oksenberg Rorty, the author
analyses the concept of tolerance, and the age peculiarities of the primary school
students.
In the empirical part of the research the author analyses how Christianity lessons
promote tolerance among students in the primary school. In this part, the author uses the
following research methods: interview and analysis of documents.
As a result of the research, the author of the paper can conclude that Christianity
lessons promote tolerance by showing the example of it – Jesus, whose life is described
in the Christianity lessons.
Key words: tolerance, primary school student, Christian lessons, promotion of
tolerance, analysis of documents, structured interview
Characterization of the TCRB chain repertoire in the New World monkey Callithrix jacchus.
No full text- …
