1,721,107 research outputs found
Clinical efficacy of autologous platelet-rich plasma (PRP) in canine perianal fistulas and aural hematomas
No full textPlatelet-rich plasma (PRP) derived from whole blood, is characterized by platelet concentrations above baseline in a small volume of plasma that leads to increased concentration of platelet-derived growth factors which can stimulate cell proliferation and decrease the inflammatory reaction accelerating the healing process.
The aim of this study was to report the clinical efficacy of autologous PRP obtained with a double centrifugation validated method [1] in the treatment of canine aural hematoma and perianal fistula.
DOG 1
German Shepherd, 11-year-old female, with multiple perianal fistulas, treated with systemic antibiotics and local disinfections without improvement for two months. The dog had 5 perineal fistulas, three of which confluent with each other, with erythema, serum/hematic exudate and dyschezia.
DOG 2
Rhodesian Ridgeback, 7-year-old female, with monolateral aural hematoma caused by accidental trauma, appeared 21 days before, treated with centesis and
corticosteroids therapy, with initial improvement, but subsequent relapse. The dog had an unorganized right aural hematoma, size 4,5 x 5 cm, 2 cm thickness.
DOG 3
Maltese, 4-year-old male, with monolateral aural hematoma, caused by intense head shaking for bilateral bacterial otitis, appeared 10 days before, treated with
centesis and compression bandage, without any improvement. The dog had a partially organized right aural hematoma, size 6 x 5 cm, 3 cm thickness, with 2
areas of necrosis with purulent exudate on the edges of ear pinna, erythema and pain.
PROCEDURES AND FOLLOW UP
A medium volume of 0.5 ml of PRP was obtained from a blood sample of 8 ml following a protocol previously described.
1
The autologous PRP was injected 2 times directly into fistulas (0,1 ml for each fistula), while for the aural hematomas it was injected only once after a complete centesis of liquid using the same hole
of the drainage inlet. The dogs were checked every 3 days for two week and then two times a month for 2 months to evaluate the improvement with a clinical
score and photographic documentation. All dogs have a complete healing of the lesions after one month of treatment with PRP, without using other drugs other
than antibiotics. No recurrences were observed in one month follow up.
Autologous PRP obtained with an in-house double centrifugation method appears to be an effective, minimally invasive therapy in the treatment of perianal
fistulas and aural hematoma in dogs
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Successful treatment of 15 cases of canine traumatic aural hematoma using autologous platelet rich plasma (PRP)
No full textPlatelet-rich plasma (PRP) derived from whole blood, is characterized by platelet (PLT) concentrations above baseline in a small volume of plasma that can accelerate the healing process [1] by providing elevate concentration of platelet-derived growth factors [2] which can stimulate cell proliferation and decrease of inflammatory reaction. Following the excellent results obtained on a small number of subjects previously reported in a preliminary study [3], in this prospective in vivo study we aimed to describe the clinical efficacy of autologous PRP in the treatment of canine traumatic aural hematoma secondary to otitis externa. After approval by the Ethics Committee of the University of Milan and with the owner informed consent, 20 ml of citrate whole blood were obtained from the cephalic vein of 15 dogs with traumatic aural hematoma of different breeds, 6 males and 9 females, with a age range of 1 -15 years (mean ± DS: 7,4 ± 3,7 years). All subjects had a history of multiple centesis, sometimes associated with injections of cortisone in situ, with subsequent recurrences of hematoma. PRP was produced using a semi-automatic closed system (CPUNT 20, Eltek group, Casale Monferrato, Alessandria, Italy) for veterinary use [4]. The serum-hematic content of the auricular pinna was completely drained using one or more 20G needles (depending of hematoma organization) and, using the same hole of the drainage inlet, the PRP was then injected. The dogs were subjected to weekly follow up for a minimum of 45 days from the first treatment. In case of partial or total recurrence of the aural hematoma of the first follow-up, the treatment was repeated with the same procedure. No dog has been subjected to anaesthesia during the procedures. At D0 the aural hematoma was present for 17 ± 13 days and the mean of the drained serum-hematic content was 23 ± 30 ml. Four dogs had a partially organized aural hematoma. 1.3 ± 0.6 ml of PRP were injected, with a mean concentration of 1185 ± 908 x 103/μl PLT (minimum value: 308 x 103/μl PLT maximum value: 4141 x 103/μl PLT, 500% mean increase compared to whole blood). 12/15 subjects were treated with a single application (Group A1), 3/15 with two applications (Group A2). 2/15 subjects were lost after the first follow up. For the remaining 13/15 the mean healing time was 15.8 ± 8.1 days (A1) and 24 ± 5.2 days (A2). No subjects showed recurrences at 45 days follow up. No side effects have been registered. The in situ administration of PRP was effective in the treatment of traumatic aural hematoma secondaty to otitis externa in dogs, leading to complete resolution of the disease in all treated subjects.
[1] Marx R.E. Platelet-Rich Plasma (PRP), what is PRP and what is not PRP? Implant Dentistry 2001, 10, 225-228. [2] Souza T.F. et al. Healing and expression of growth factors (TGF-β and PDGF) in canine radial ostectomy gap containing platelet-rich plasma. Vet Comp Orthop Trauma, 2012, 25, 445-452. [3] Perego R. et al. Efficacia clinica del plasma ricco di piastrine (prp) autologo ottenuto con metodo chiuso semi-automatico nel trattamento dell’otoematoma nel cane. 2017. 56° Congresso AIVPA, Piacenza. [4] Perego R. et al. Evaluation of a commercial closed system for autologous platelet-rich plasma production in dog. 2016. ESVCP-ESVONC Congress, Nantes
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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