1,721,077 research outputs found
Obesità : la patologia del nuovo millennio?
Full text linkCon il termine obesità si definisce un accumulo eccessivo di grasso (adiposità), presente nell’uomo come negli animali d’affezione. Questa definizione risulta quanto mai riduttiva, poichè questa condizione non rappresenta una semplice raccolta di grasso inerte, ma il punto di partenza di complicanze metaboliche (insulino resistenza, dislipidemie ed alterazione della secrezione di adipochine) ben più complesse. Infatti, è oramai archiviata la visione del tessuto adiposo come un organo inerte, ma è sempre più riconosciuto il suo ruolo come tessuto endocrino attivo, in grado di partecipare attivamente al metabolismo di lipidi e carboidrati, nella regolazione del metabolismo energetico e nella cascata infiammatoria (4). A fronte di tale riconoscimento scientifico, la condizione di sovrappeso o di obesità è sempre più frequente nei nostri animali da compagnia. Diverse e molteplici possono essere le strategie dietetiche da mettere in atto per contrastare questa condizione spesso non riconosciuta tempestivamente come malattia
Influence of antioxidants on ruminant health
No full textThis article discusses the role or vitamins (A, C and E), trace elements (copper, zinc, manganese and selenium), flavonoids, isoflavones and essential oils in improving the antioxidant status of cattle and other ruminant
Cell-based models for mycotoxin screening and toxicity evaluation : an update
No full textThis review presents the applications of cell-based models in mycotoxin research, with a focus on models for mycotoxin screening and cytotoxicity evaluation. Various cell-based models, cell and cell culture condition related factors, toxicity endpoints and culture systems as well as predictive value of cell-based bioassays are reviewed. Advantages, drawbacks and technical problems regarding set up and validation of consistent, robust, reproducible and high-throughput cell-based models are discussed. Various cell-based models have been developed and used as screening tests for mycotoxins but the data obtained are difficult to compare. However, the results highlight the potential of cell-based models as promising in vitro platforms for the initial screening and cytotoxicity evaluation of mycotoxins and as a significant analytical approach in mycotoxin research before any animal or human clinical studies. To develop cell-based models as powerful high-throughput laboratory platforms for the analysis of large numbers of samples, there are mainly two fundamental requirements that should be met, i.e. the availability of easy-to-use and, if possible, automated cell platforms and the possibility to obtain reproducible results that are comparable between laboratories. The transition from a research model to a test model still needs optimisation, standardisation, and validation of analytical protocols. The validation of a cell-based bioassay is a complex process, as several critical points, such as the choice of the cellular model, the assay procedures, and the appropriate use and interpretation of the results, must be strictly defined to ensure more consistency in the results. The development of cell-based models exploring the third dimension together with automation and miniaturisation will bring cellular platforms to a level appropriate for cost-effective and large-scale analysis in the field of mycotoxin research
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Bibbie miniate della Biblioteca Medicea Laurenziana di Firenze, a cura di L. Alidori, L. Benassai, L. Castaldi, M. Ceccanti, E. Fusi, E. Mattia, S. Nencioni, Premessa di C. Guiducci Bonanni, Presentazione di F. Arduini, Prefazione di C. Leonardi, con saggio introduttivo di M. G. Ciardi Dupré Dal Poggetto
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Tests in vitro per la valutazione dell'attività biologica di lattoferrina suina ricombinante
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