1,721,013 research outputs found

    Investigating the sulfhydryl redox status in the hypotensive acute effects of peroxyl radicals

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    Post-prandial hypotension is a well-known phenomenon. We aimed to investigate, in the absence of immune and metabolic interfering factors, the correlation of the plasma antioxidant capacity with the early alterations of blood pressure induced by peroxyl radicals. We previously suggested that the hypotensive effect of acute infusion of peroxyl radical generators in rats could be mediated by sulfhydryl (SH) redox status. Therefore, in this study we evaluated the plasma SH, peroxides (ROOH) and both lipophilic (LAC) and hydrophilic (HAC) antioxidant capacity, before, during and after the hypotension induced by 2,2’-azobis- (2-amidinopropane) dihydrochloride (AAPH) and 2,2’-Azobis 2,4-di-methylvaleronitrile (AMVN). As a result AAPH infusion induced a rapid decrease of HAC and SH, these effects were followed by a strong increase of both markers, whereas AMVN treatment was unable to change the HAC and SH values. On the other hand AMVN reduced plasma LAC and increased ROOH, while, in the animals treated with AAPH, ROOH and LAC were decreased and unchanged, respectively. Therefore, SH redox status seems to be not involved in the hypotensive acute effects of peroxyl radicals. Further studies are needed to better understand the mechanisms responsible for paradoxical effects of acute oxidative stres

    Parasomnias in children

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    The International Classification of Sleep Disorders (ICSD-2) defines parasomnias as "undesirable physical events or experiences that occur during entry into sleep, within sleep, or during arousal from sleep." Parasomnias in childhood are common, more often benign, self-limited and typically resolving in adolescence. However, for the diagnosis it is often difficult to distinguish between other epileptic and/or non-epileptic events during sleep. Polysomnography is not always sufficient for the diagnosis and video polysomnography may be indicated to assist in the definition of parasomnias or other sleep disruption thought to be seizure related or in a presumed parasomnia, especially when it is not possible for the clinician to identify the etiology of the motor activity in sleep. The correct recognition of parasomnias is important to avoid misdiagnosis and to choose the appropriate treatment, when needed. We review here the main form of childhood parasomnias divided into three groups: 1) disorders of arousal (from NREM sleep); 2) parasomnias usually associated with REM sleep; 3) other parasomnias. Further studies are needed to elucidate the genetics, the pathophysiology and the triggering factors and also to clarify the relationship between NREM sleep structure and the occurrence of the episodes. © 2008 Steinkopff-Verlag

    Butter quality improvement by a new dry-sweating technique

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    The work deals with a new dry sweating technique to reduce the content of cholesterol in butter. The applied technique consisted of charging a basket centrifuge with butter and heating it up by a hot nitrogen stream during the centrifuge operation. The heating induces a partial melting of the butter and the centrifugal force allows a quick melt-solid separation

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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