391 research outputs found
Some phonetic problems of a public address in english
No full textFesenko E. A. Some phonetic problems of a public address in english [Электронный ресурс] / Fesenko E. A.// Язык как инструмент понимания и непонимания : русско-американские лингвистические и культурные сопоставления : материалы Междунар. науч.-практ. конф., РГГУ (Москва), 26-27 февр. 2008 г. - Москва : РГГУ, 2008. - С. 237-244
Some phonetic problems of a public address in english
No full textFesenko E. A. Some phonetic problems of a public address in english [Электронный ресурс] / Fesenko E. A.// Язык как инструмент понимания и непонимания : русско-американские лингвистические и культурные сопоставления : материалы Междунар. науч.-практ. конф., РГГУ (Москва), 26-27 февр. 2008 г. - Москва : РГГУ, 2008. - С. 237-244
Fesenko reciprocity map
Get PDFIn recent papers, Fesenko has defined the non-Abelian local reciprocity map for every totally ramified arithmetically profinite (APF) Galois extension of a given local field K, by extending the work of Hazewinkel and Neukirch-Iwasawa. The theory of Fesenko extends the previous non-Abelian generalizations of local class field theory given by Koch-de Shalit, and by A. Gurevich. In this paper, which is research-expository in nature, we give a detailed account of Fesenko's work, including all the skipped proofs
Micromagnetic modelling of magnetic domain walls and domains in cylindrical nanowires.
Get PDFFernandez-Roldan, J. A., Ivanov, Y. P., & Chubykalo-Fesenko, O. (2019). Micromagnetic modelling of magnetic domain walls and domains in cylindrical nanowires. arXiv preprint arXiv:1907.02318.[EN] Magnetic cylindrical nanowires are very fascinating objects where the curved geometry allows many novel magnetic effects and a variety of non-trivial magnetic structures. Micromagnetic modelling plays an important role in revealing the magnetization distribution in magnetic nanowires, often not accessible by imaging methods with sufficient details. Here we review the magnetic properties of the shape anisotropy-dominated nanowires and the nanowires with competing shape and magnetocrystalline anisotropies, as revealed by micromagnetic modelling. We discuss the variety of magnetic walls and magnetic domains reported by micromagnetic simulations in cylindrical nanowires. The most known domain walls types are the transverse and vortex (Bloch point) domain walls and the transition between them is materials and nanowire diameter dependent. Importantly, the field or current-driven domain walls in cylindrical nanowires can achieve very high velocities. In recent simulations of nanowires with larger diameter the skyrmion tubes are also reported. In nanowires with large saturation magnetization the core of these tubes may form a helicoidal (“corkscrew”) structure. The topology of the skyrmion tubes play an important role in the pinning mechanism, discussed here on the example of FeCo modulated nanowires. Other discussed examples include the influence of antinotches (“bamboo” nanowires) on the remanent magnetization configurations for hcp Co and FeCo nanowires and Co/Ni multisegmented nanowires.Peer reviewe
Cell adhesion in the preimplantation mammalian embryo and its role in trophectoderm differentiation and blastocyst morphogenesis
No full textCell adhesion plays a critical role in the differentiation of the trophectoderm epithelium and the morphogenesis of the blastocyst. In the mouse embryo, E-cadherin mediated adhesion initiates at compaction at the 8-cell stage, regulated post-translationally via protein kinase C and other signalling molecules. E-cadherin adhesion organises epithelial polarisation of blastomeres at compaction. Subsequently, the proteins of the epithelial tight junction are expressed and assemble at the apicolateral contact region between outer blastomeres in three phases, culminating at the 32-cell stage when blastocoel cavitation begins. Cell adhesion events also coordinate the cellular allocation and spatial segregation of the inner cell mass (ICM) of the blastocyst, and the maintenance of epithelial (trophectoderm) and non-epithelial (ICM) phenotypes during early morphogenesis
The Field of Norms Functor and the Hilbert Symbol
Get PDFThe classical Hilbert symbol of a higher local field containing a primitive -th root of unity is a pairing , describing Kummer extensions of exponent . In this thesis we define a generalised Hilbert symbol and prove a formula for it. Our approach has several ingredients.
The field of norms functor of Scholl associates to any strictly deeply ramified tower a field of characteristic . Separable extensions of correspond functorially to extensions of , giving rise to .
We define morphisms which are compatible with the norms for every . Using these, we show that field of norms functor commutes with the reciprocity maps and constructed by Fesenko.
Imitating Fontaine's approach, we obtain an invariant form of Parshin's formula for the Witt pairing in characteristic . The `main lemma' relates Kummer extensions of and Witt extensions of , allowing us to derive a formula for the generalised Hilbert symbol , where is the -adic completion of
Tight junction assembly during mouse blastocyst formation is regulated by late expression of ZO-1 a+ isoform
No full textThe mouse preimplantation embryo has been used to investigate the de novo synthesis of tight junctions during trophectoderm epithelial differentiation. We have shown previously that individual components of the tight junction assemble in a temporal sequence, with membrane assembly of the cytoplasmic plaque protein ZO-1 occurring 12 hours before that of cingulin. Subsequently, two alternatively spliced isoforms of ZO-1 (alpha+ and alpha-), differing in the presence or absence of an 80 residue alpha domain were reported. Here, the temporal and spatial expression of these ZO-1 isoforms has been investigated at different stages of preimplantation development. ZO-1alpha- mRNA was present in oocytes and all preimplantation stages, whilst ZO-1alpha+ transcripts were first detected in embryos at the morula stage, close to the time of blastocoele formation. mRNAs for both isoforms were detected in trophectoderm and ICM cells. Immunoprecipitation of 35S-labelled embryos also showed synthesis of ZO-1alpha- throughout cleavage, whereas synthesis of ZO-1alpha+ was only apparent from the blastocyst stage. In addition, 33P-labelling showed both isoforms to be phosphorylated at the early blastocyst stage. The pattern and timing of membrane assembly of the two isoforms was also distinct. ZO-1alpha- was initially seen as punctate sites at the cell-cell contacts of compact 8-cell embryos. These sites then coalesced laterally along the membrane until they completely surrounded each cell with a zonular belt by the late morula stage. ZO-1alpha+ however, was first seen as perinuclear foci in late morulae before assembling at the tight junction. Membrane assembly of ZO-1alpha+ first occurred during the 32-cell stage and was zonular just prior to the early blastocyst stage. Immunostaining indicative of both isoforms was restricted to the trophectoderm lineage. Membrane assembly of ZO-1alpha+ and blastocoele formation were sensitive to brefeldin A, an inhibitor of intracellular trafficking beyond the Golgi complex. In addition, the tight junction transmembrane protein occludin co-localised with ZO-1alpha+ at the perinuclear sites in late morulae and at the newly assembled cell junctions. These results provide direct evidence from a native epithelium that ZO-1 isoforms perform distinct roles in tight junction assembly. Moreover, the late expression of ZO-1alpha+ and its apparent intracellular interaction with occludin may act as a final rate-limiting step in the synthesis of the tight junction, thereby regulating the time of junction sealing and blastocoele formation in the early embryo. <br/
E-Government development strategies in the Eastern Partnership countries
Get PDFThe article aims to outline the role of e-democracy within the setting of the Eastern Partnership program. The article provides the comparative review of E-Government progress in six EaP countries in 2009 – 2016. The E-Government sensitive data of international ratings is analyzed with the special focus on participative aspects. The existing differences of E-Government strategies between the Eastern Partnerships countries are analyzed with the special focus on e-participate. The e-participate differences in the development of the countries are pointed out in terms of e-democracy development. The cognitive model of integrating e-democracy components into the socio-technical system of e-government is proposed.
Article DOI : 10.5958/2347-6869.2017.00007.
Society for Reproductive Biology Founders' Lecture 2003 - The making of an embryo: short-term goals and long-term implications
No full textDuring early development, the eutherian mammalian embryo forms a blastocyst comprising an outer trophectoderm epithelium and enclosed inner cell mass (ICM). The short-term goal of blastocyst morphogenesis, including epithelial differentiation and segregation of the ICM, is mainly regulated autonomously and comprises a combination of temporally controlled gene expression, cell polarisation, differentiative cell divisions and cell–cell interactions. This aspect of blastocyst biogenesis is reviewed, focusing, in particular, on the maturation and role of cell adhesion systems. Early embryos are also sensitive to their environment, which can affect their developmental potential in diverse ways and may lead to long-term consequences relating to fetal or postnatal growth and physiology. Some current concepts of embryo–environment interactions, which may impact on future health, are also reviewed
Assembly of tight junctions during early vertebrate development
No full textTight junction formation during development is critical for embryonic patterning and organization. We consider mechanisms of junction biogenesis in cleaving mouse and Xenopus eggs. Junction assembly follows the establishment of cell polarity at 8-cell (mouse) or 2-cell (Xenopus) stages, characterized by sequential membrane delivery of constituents, coordinated by embryonic (mouse) or maternal (Xenopus) expression programmes. Cadherin adhesion is permissive for tight junction construction only in the mouse. Occludin post-translational modification and membrane delivery, mediated by delayed ZO-1 alpha+isoform expression in the mouse, provides a mechanism for completion of tight junction biogenesis and sealing, regulating the timing of blastocoel cavitation
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