1,720,969 research outputs found
The Cdk5 kinase downregulates ATP-gated ionotropic P2X3 receptor function via serine phosphorylation
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Modulation of purinergic signaling by algogens in cultures from trigeminal sensory ganglia
Full text linkkoamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Studies of familial hemiplegic migraine transgenic mouse models and patients to investigate the crosstalk between sensory neurons and neuroinflammatory cells in trigeminal ganglia in relation to migraine pain
No full textThe main aim of the our research project is to understand what occurs to pain transduction mechanisms of trigeminal sensory neurons in migraine, why they become hyperactive, and how we may stop them. Our project proposes to identify the chemical processes (including soluble messengers, with a specific focus on the purinergic system) used by trigeminal ganglion neurons to crosstalk with satellite glial cells (SGCs), and how this process might recruit neuroimmune cells to create a latent neuronal sensitization though which acute attacks are facilitated. To this end, we have employed tissues from a genetic mouse model of migraine, the Cav2.1 R192Q mutant knock-in (KI) mice expressing a human mutation causing familial hemiplegic migraine type 1 (FHM1). Concerning the role of metabotropic purinergic receptors, our data show that application of bradykinin (BK) to primary mixed trigeminal cultures induces neuronal release of the pro-algogenic mediator calcitonin gene-related peptide (CGRP), which in turn potentiates the ADP-responsive P2Y1 and the UTP-sensitive P2Y2 receptor subtypes on surrounding SGCs (Ceruti et al., J Neurosci 31:3638-49, 2011). The increased activity of P2 receptors is not only due to increased receptor protein expression, but also, and especially for the P2Y1 subtype, to modulation of the receptor localization to membrane lipid rafts. In vivo studies on the possible pro- or anti-algogenic role of these receptor subtypes are currently in progress. Interestingly, the anti-migraine drug sumatriptan fully inhibits both CGRP release and glial P2Y-receptor potentiation. Moreover, exposure to BK leads to increased production of PGE2, an effect completely abolished by the COX-1 inhibitor acetylsalicylic acid. The latter also blocks neuronal CGRP release. Taken together, these results suggest a possible role for receptors activated by adenine and uracil nucleotides in the mechanism of action of currently employed anti-migraine drugs. Unlike wild type (WT) trigeminal cultures, R192Q KI trigeminal ganglion cultures show basal macrophage activation together with enhanced TNFalpha release and neuronal currents mediated by P2X3 receptors. LPS application stimulates TNFalpha mRNA and WT P2X3 neuronal currents with faster recovery from desensitization (Franceschini et al. Purinergic Signal. 2012 in press). Furthermore, co-culturing WT or KI ganglia with host macrophages strongly stimulate phagocytosis (Franceschini et al. BMC Neurosci 2012 in press). These data suggest a basal neuroinflammatory profile in KI ganglia that facilitates the release of endogenous mediators (including ATP) to activate P2X3 receptors and amplify nociceptive signaling by trigeminal sensory neurons. The complex molecular cross-talk occurring even in basal conditions in KI ganglia further strengthen the role of purinergic receptors in the onset and maintenance of migraine-associated pain
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