1,721,077 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Progetto PRIN "Traditional and non traditional risk predictors of cardiovascolar disease and restenosis" Sottoprogetto: Genetic, plasmatic and cellular markers of restenosis after carotid endarterectomy
No full textAtherosclerosis and its devastating clinical complications such as arterial thrombosis, myocardial infarction, ruptured aortic
aneurysms and stroke, are the leading cause of illness and death in Western countries. Carotid atherosclerotic plaque is causative of
cerebrovascular insufficiency and represents the most frequent lesion associated to ischemic stroke (Wein and Bornstein 2000).
Carotid endarterectomy (CEA), the most frequently performed intervention in vascular surgery, and still the gold standard
procedure for hemodynamically significative carotid atherosclerosis(Mayberg et al, 1991), constitutes an injury to the vascular wall,
which is followed by arterial wall healing response.
Only in a small percentage of cases (4-7%) exaggeration of the normal reparative process ensues, which leads to a hemodinamically
significant re-narrowing (restenosis) of the vessel lumen. Restenosis is the main cause of failure in vascular surgery and represents
the most frequent long-term complication of carotid artery surgery. The restenotic process occurs more frequently between 3 to 12
months after surgery, less frequently thereafter. It represents an important clinical problem, in as much as patients with restenosis
require a tight follow-up and eventually new interventions.
The mechanisms underlying the restenotic process have been studied mainly in the coronary arteries, where this complication after
percutaneous transluminal coronary angioplasty (PTCA) revascularization is much more frequent (30-50%). This difference in
frequency can be ascribed to the different injury caused by revascularization procedures: during CEA the plaque is completely
removed, while it is crushed and disrupted during PTCA.
Cell migration and proliferation, matrix remodeling and thrombus deposition at injury site are believed to be important factors in
the pathogenesis of the restenotic process (Schwartz, 1998). However, the biochemical and cellular components implicated, and the
molecular mechanisms of the vascular response to injury are only partially known. Moreover, animal models of restenosis have
many and important limitations. Taking into account the research expertise of our group, the study will particularly focus on issues related to the hemostatic process,
or others components that can interact with this pathway and among them:
a) regulation of endothelial function, that includes production of hemostatic molecules (i.e. vonWillebrand factor) or receptors
(TFPI, thrombomodulin, protein C receptor), negative regulators of the coagulation process;
b) inflammation, influencing the expression of several coagulation factors, among them tissue factor and fibrinogen;
c) receptors directing plasma molecules to the intracellular degradation and thus potential regulators of levels of coagulation
factors and matrix proteases;
d) proteolytic components that could interact with the main proteolytic system able to degrade fibrin, the fibrinolytic system.
Although most of the markers proposed for this study have been suggested to contribute to restenosis, conflicting results and
sporadic findings have been produced.
The components of the primary carotid atherosclerotic plaque (endarterectomy specimens) and of the restenotic lesion have been
poorly investigated in humans.
This phase of the project is designed to compare the primary lesions with the restenotic ones for morphology and specific markers to
improve the knowledge on the origin of cells responsible for the restenotic tissue.This part of the project will be developed in the frame of a recently established collaboration with the Department of Pathology and
Immunology, Geneva (dr. ML Bochaton-Piallat, prof.G. Gabbiani).
Expression of candidate genes will be investigated in tissue specimens by in situ RNA hybridisation to reinforce findings from the
association studies performed in the first part of the project.
It's worth noting that, whereas protein studies are limited by availability of proper functional or antigenic assays, probes to
investigate the expression at the mRNA level can be designed virtually for all genes.
Associations with a weak statistical significance could be validated by these approaches (immunohistochemistry and in situ
hybridisation).
Vascular Smooth Muscle Cells (V-SMC) are the main contributor to the atherosclerotic lesion and are strong candidates for the
restenotic process.Cultured V-SMC will be characterized for differentiation markers used to discriminate between SMCs and myofibroblasts.
In the human V-SMC model we will investigate:
- TF expression (ELISA, Western Blotting)
- TF activity by FXa generation fluorogenic assay in cell lysates and medium.
- TF bearing microparticles from V-SMC, after Fas-Ligand induced apoptosis, will be quantified by flow cytometry after labelling
with the annexin V-FITC
- …
