1,720,997 research outputs found
CD4+, CD8+ lymphocyte depletion and cytotoxicity induced by the organotin TPTA in the mouse.
No full textApoptosis and CD4+, CD8+ lymphocyte depletion following triphenyltin acetate (TPTA) exposure in mice thymic primary culture.
No full textUn relitto da Cala Rossano (Ventotene). Tituli picti su anfore e bollo su lingotti di stagno
No full textArata Francesco Paolo. Un relitto da Cala Rossano (Ventotene). Tituli picti su anfore e bollo su lingotti di stagno. In: Epigrafia della produzione e della distribuzione. Actes de la VIIe Rencontre franco-italienne sur l'épigraphie du monde romain (Rome, 5-6 juin 1992) Rome : École Française de Rome, 1994. pp. 477-496. (Publications de l'École française de Rome, 193
In vitro effects of triphenyltin acetate (TPTA) on mouse lymphocyte proliferation
No full textOrganotin compounds (OTs) are used worldwide in industry and in agricultural practice. In Italy, the OT mostly used is the fungicide triphenyltin acetate (TPTA), although in past years it has been submitted to revision for occupational and environmental grounds. In the present study, the possible effect of the fungicide on cell proliferation has been investigated, using [(3)H]thymidine incorporation radiometric assay. Mouse thymocytes in primary culture were stimulated for 24 h with T- and B-cell mitogens (concanavalin A, CON A and phytohemagglutinin, PHA or pokeweed mitogen, PWM, respectively). Cultures were then exposed 24 h to 0, 1 and 8 microM TPTA. At the end of incubation, cells were pulsed with methyl-[(3)H]thymidine and harvested for total radioactivity counts after a further 24 h of incubation. An overall dose-dependent significant (P<0.05) reduction of proliferative response was observed with all mitogens tested. Interestingly, CON A proved to be more sensitive (P<0.05) to the TPTA toxic effect compared with PWM and PHA. TPTA is cytotoxic to mouse thymocytes in primary culture, particularly towards the mature lymphocytes (CD4(+) and CD8(+)). The present results support the hypothesis of a TPTA-induced decrease of lymphoproliferative response to T- and B-cell mitogens, previously observed with other OT
Effects of dexamethasone on the bovine immune system: cellular and humoral immune responses
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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