1,721,074 research outputs found
Estensione del Disegno Continual Reassessment Methods (CRM) allo studio di misure ripetute di tossicità in studi Clinici oncologici di fase I .
Full text linkA modified version of Continual Reassessment Methods for longitudinal data in Phase I cancer Clinical Trials.
Background: In Phase I studies, the Maximum Tolerated Dose (MTD) of a new drugs is determined on the basis of dose limiting toxicities (DLT) observed during the first cycles of treatment. Cancer therapies are however administered in repeated courses with a risk of cumulative toxicities that could compromise the development of the drugs. Information about DLT occurred during the entire treatment period need to be included in the dose-response model. To this aim, we propose a phase I design that is a extension to the Modified Continual Reassessment Method (M-CRM) proposed by Goodman et al..
Method: We propose two hierarchical dose-toxicity logistic models for binary correlated responses, with one and two parameters respectively. Data on a combination phase I Italian study are used to evaluate differences in the MTD between the traditional design (3+3) used in the study protocol, M-CRM and CRM with mixed models. For the analysis DLT was defined as any toxicity of grade>2 (CTCAE v.3.1).
Results: Enrolled patients were sequentially assigned to four dose levels (2.5;5;7.5;10 mg/day). 3+3 patients were assigned each dose except for the second dose (only 3 patients). The MTD from the study was the higher dose level. The number of toxicities for each dose were 0, 0, 2, 2. Results from the logistic, one parameter, mixed model showed, on the average, an high risk of toxicity respect to fixed effect models (M-CRM) on the first cycle of therapy. The third dose level was identified as MTD (probability p=0.325, IC80%[0.23-0.42]).
Conclusions: When a cumulative toxicity effect is supposed, the use of a longitudinal design could be appropriate. To avoid a delay in the study duration a limit must be fixed in advance on the number of cycle on which the dose escalation is based. Operating characteristics of the proposed design could be evaluated through a simulation study
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
[Porokeratosis and immunosuppressive therapy. Presentation of a further case and review of the literature]
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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