1,721,681 research outputs found
Recensione di E. Berti, Il Critone latino di Leonardo Bruni Aretino e di Rinuccio Aretino, edizioni critiche di E. Berti e A. Carosini, Firenze 1983
No full textRecensione critica alle edizioni delle versioni latine di Leonardo Bruni e Rinuccio Aretino del Critone di Platone curate da E. Berti e A.Carosini
Indice dei nomi. In E. Berti, Sumphilosophein. La vita nell'Accademia di Platone, Laterza, Roma-Bari, 2010
No full textIndice dei nomi relativo al volume di E. Berti, Sumphilosophein. La vita nell'Accademia di Platone, Laterza, Roma-Bari, 201
Sobre las críticas modernas a la metafísica aristotélica y su discusión en E. Berti
Full text linkOn the collective work edited by P. Rossi, E. Berti have written the section dedicated to metaphysics. A review of this contribu-tion is attempted. Some personal remarks about modern critics to metaphysics are introduced whenever they differ from Berti’s
Subcutaneous panniculitis-like T-cell lymphoma
No full textSubcutaneous panniculitis like T-cell lymphoma derived from α/β T-cells (SPTCL-AB) belongs to the group of primary cutaneous T-cell lymphoma, and it represents less than the 1% of all primary cutaneous T-cell lymphomas. It affects patients in the 4th decade of life (median age of 36 years) with a female preference (male/female ratio 0.5) with 19% of patients being 20 years or younger. It can be sometime complicated by a hemophagocytic syndrome, and patients without hemophagocytic syndrome had a significantly better survival (5-year OS: 91% vs. 46%). Histopathologically, SPTCL-AB is characterized by a lobular lymphocytic panniculitis. Tumor cells distribute between individual adipose lobules, proliferating and forming "rim" and "capping" images, conferring a lace-like appearance at scanning magnification. This is not an entirely disease-specific feature, and can also be seen in other lobular lymphocytic panniculitis, either of inflammatory and neoplastic origin. Tumor cells are phenotypically CD45RO+, βF1+ (a monoclonal antibody able to identify the alpha/beta chain of TCR), CD3+, CD4-, CD8+, and express cytotoxic granules (TIA-1, granzyme and perforin), whereas they show variable deletion of T-cell restricted antigens like CD2, CD5 and CD7. The majority of cases show a monoclonal rearrangement for TCR beta and gamma genes and do not show genomic integration of EBV. The present review will focus on histopathologic, immunophenotypical and molecolare data useful to overcome to a specific diagnosis of SPTCL-AB and to differentiate SPTCL-AB from other lymphomas of T-cell or NK/T cell origin and with benign panniculitidis sharing with SPTCL-AB a predominant lobular lymphocytic pattern of involvement of subcutaneous tissue
Etica, politica, retorica. Studi su Aristotele e la sua presenza nell'età moderna e contemporanea
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INTEGRINS AND SKIN TUMORS
No full textIt is well know that cell-cell and cell-matrix interactions play an important role in maintaining the integrity of pluristratified epithelia and in different biological processes such as wound healing, inflammation, and immune response. In addition, growing evidence indicates that these interactions are also fundamental in tumour cell growth and invasion. Important advances in the understanding the mechanism of cell adhesion has been possible owing the identification and characterization of a large number of specific cell adhesion molecules. Integrins are a family of transmembrane adhesion receptors that mediate cell adhesion to extracellular matrix protein and to the surface of other cells. In this review the structure and the function of these adhesion receptors are summarized, and their possible involvement in skin tumours is discussed. The peculiar distribution pattern of some members of the integrin famil (α6β4, α5β1, and α10.1.2 integrins) found in neoplastic cells of squamous cell carcinoma (SCC), may reflect the different biological behavior of this tumour as compared to basal cell carcinoma (BCC). Therefore immunohistochemical study of integrins expression may be used for the phenotypic classification of tumours and as indicator of invasiveness. Finally, increasing evidence indicates that integrins are able to transmit signals from the extracellular matrix to the cell interior, that control gene expression, the cell cycle, and tumour growth. Thus, the role of integrins in cancer seems not only to involve cell adhesion events, but may also involve the regulation of cell growth and differentiation
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