139,235 research outputs found
Leptin resistance: underlying mechanisms and diagnosis
No full textOlga Gruzdeva,1,2 Daria Borodkina,3 Evgenya Uchasova,1 Yulia Dyleva,1 Olga Barbarash1,2 1Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation; 2Federal State Budget Educational Institution of Higher Education, Kemerovo State Medical University of the Ministry of Healthcare of the Russian Federation, Kemerovo, Russian Federation; 3Autonomous Public Healthcare Institution of the Kemrovo Region, Kemerovo Regional Clinical Hospital Named After S.V. Beliyaev, Regional Center for Diabetes, Kemerovo, Russian Federation Abstract: Leptin and its receptors have been identified as key regulators of body weight and energy homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity and metabolic disorders, such as insulin resistance and dyslipidemia. Mechanisms underlying the development of leptin resistance include mutations in the genes encoding leptin and its receptors, as well as proteins involved in self-regulation of leptin synthesis and blood–brain barrier permeability. Leptin resistance encompasses a complex pathophysiological phenomenon with a number of potential research lines. In this review, we analyze the existing data on the methods used to diagnose leptin resistance. Keywords: leptin, leptin resistance, soluble leptin recepto
Spatially-localized time dependent solutions including turbulence and their interactions in 2D Kolmogorov flow
No full textIn 2D Kolmogorov flow in small aspect ratio domains, spatially-localized solutions such as kink, traveling or time-dependent kink-antikink pars coexist. However, the conservation of the flow rate in the y direction strongly restrict combination of localized solutions and their positioning. We find that by adding a homogeneous flow U y their positioning is controlled and each of localized solutions including a spatially-localized chaos is isolated. Numerical results suggest that these isolated solutions can be elements constructing a whole flow
Characteristics of overlap region in high-Reynolds number turbulent channel flow
No full textDirect numerical simulation of the fully developed turbulent channel flows have been carried out at the Reynolds number based on the friction velocity and the channel half width, 2000, 4000 and 8000. A hybrid 10th order accurate finite difference scheme in the stream and spanwise directions, and a second-order scheme in the wall-normal direction is adapted as the spatial discretization method. We observed the plateau profiles in the indicator function corresponded to the von Karman constant. Furthermore, second peak of streamwise pre-multiplied spectra were appeared in the same wall normal height, 300 < y+ < 600, in case of Re = 4000. Nevertheless, the effects of the lager than the channel half height scale on the streamwise turbulent intensity are fixed contributions without dependence on Reynolds number. These results suggested that the new streamwise vortexes are formed between buffer layer and outer layer with increasing of Reynolds number
La 'circunstancia' de 'Herederos y Pretendientes
No full textIn June 2010, the Ortega y Gasset Foundation hosted a Conference about the “Spanish Philosophical Transition” in order to debate the book of Francisco Vázquez, La filosofía española. Herederos y Pretendientes. Una lectura sociológica (1963-1990), recently published. This paper is the author’s response to criticism raised in the Conference and to published reviews received by this book. First, the author summarized the argument of Herederos y pretendientes. Secondly he responds and takes into account the most important objections against the book’s hypothesis and methodology. Finally the author evaluates the favorable judgments received by the book and suggests the limits of the historian’s task.Fundación Ortega y Gasset-Marañó
Effect of different doses of statins on the development of type 2 diabetes mellitus in patients with myocardial infarction
No full textOlga Gruzdeva,1 Evgenya Uchasova,1 Yulia Dyleva,1 Olga Akbasheva,2 Victoria Karetnikova,1 Aleksandr Shilov,1 Olga Barbarash1 1Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia; 2State Budget Educational Institution of Higher Professional Education, Siberian State Medical University, Russian Federation Ministry of Health, Tomsk, Russia Background: Cardiovascular diseases and type 2 diabetes mellitus (T2DM) may have common developmental mechanisms associated with lipid metabolism disorders. Dyslipidemia and progression of atherosclerosis in people with T2DM are accompanied by an increase in cardiovascular mortality. This study examined the dose-dependent action of atorvastatin on carbohydrate metabolism and adipokine status in patients within 12 months after myocardial infarction (MI).Methods: A total of 156 male MI patients who had received atorvastatin 20 mg/day (78 patients) or 40 mg/day (78 patients) starting from day 1 of onset were enrolled. Glucose, insulin, C-peptide, resistin, adiponectin, and ghrelin levels were measured at baseline, day 12, and months 3 and 12. Patients were monitored for new incidences of T2DM for 12 months after MI.Results: For acute phase MI, patients had moderate insulin resistance, hyperglycemia, and hyperinsulinemia, high leptin and resistin levels, and low ghrelin and adiponectin levels. Atorvastatin 20 mg/day was more effective at correcting the imbalances. Patients taking atorvastatin 40 mg/day (group 2) following MI showed increases in levels of glucose, insulin, and C-peptide and insulin resistance progression after 12 months of therapy, as evidenced by increased quantitative insulin sensitivity check index scores and detection of new T2DM cases.Conclusion: Atorvastatin improved adipokine profiles and ghrelin levels, with low doses showing more significant effects. Atorvastatin dose prescribed for MI patients should take into account the degree of insulin resistance and adipokine status. Keywords: statin, myocardial infarction, inflammation, adipokine, resisti
Dose-dependent effects of atorvastatin on myocardial infarction
No full textOlga Barbarash, Olga Gruzdeva, Evgenya Uchasova, Ekaterina Belik, Yulia Dyleva, Victoria KaretnikovaFederal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, the Russian Federation Background: Dyslipidemia is a key factor determining the development of both myocardial infarction (MI) and its subsequent complications. Dyslipidemia is associated with endothelial dysfunction, activation of inflammation, thrombogenesis, and formation of insulin resistance. Statin therapy is thought to be effective for primary and secondary prevention of complications associated with atherosclerosis.Methods: This study examined 210 patients with Segment elevated MI (ST elevated MI) who were treated with atorvastatin from the first 24 hours after MI. Group 1 (n=110) were given atorvastatin 20 mg/day. Group 2 (n=100) were given atorvastatin 40 mg/day. At days 1 and 12 after MI onset, insulin resistance levels determined by the homeostasis model assessment of insulin resistance index, lipid profiles, and serum glucose, insulin, adipokine, and ghrelin levels were measured.Results: Free fatty acid levels showed a sharp increase during the acute phase of MI. Treatment with atorvastatin 20 mg/day, and especially with 40 mg/day, resulted in a decrease in free fatty acid levels. The positive effect of low-dose atorvastatin (20 mg/day) is normalization of the adipokine status. Administration of atorvastatin 20 mg/day was accompanied with a statistically significant reduction in glucose levels (by 14%) and C-peptide levels (by 38%), and a decrease in the homeostasis model assessment of insulin resistance index on day 12.Conclusion: Determination of atorvastatin dose and its use during the in-hospital period and subsequent periods should take into account changes in biochemical markers of insulin resistance and adipokine status in patients with MI.Keywords: myocardial infarction, statin, insulin resistance, adipokines, atorvastati
Author self-citation in orthodontics is associated with author origin and gender.
No full textBACKGROUND
The aims of this bibliometric study were to determine author self-citation trends in high-impact orthodontic literature and to investigate possible association between self-citation and publication characteristics.
METHODS
Six orthodontic journals with the highest impact factor as ranked by 2017 Journal Citation Reports were screened for a full publication year (2018) for original research articles, reviews, and case reports. Eligible articles were scrutinized for article and author characteristics and citation metrics. Univariable and multivariable negative binomial regression was used to examine associations between self-citation incidence and publication characteristics.
RESULTS
Medians for author self-citation rate of the most self-citing authors and self-citations were 3.03% (range 0-50) and 1 (range 0-19), respectively. In the univariable analysis, there was no association between self-citation counts and study type (P = 0.41), article topic (P = 0.61), number of authors (P = 0.62), and rank of authors (P = 0.56). Author origin (P = 0.001), gender (P = 0.001) and journal (P = 0.05) were associated with self-citation counts and in the multivariable analysis only origin and gender remained strong self-citation predictors. Asian authors and females self-cited significantly less often than all other regions and male authors.
CONCLUSIONS
Authors in orthodontics do not self-cite at a frequency that suggests potential citation manipulation. Author origin and gender were the only variables associated with citations counts. More bibliometric research is necessary to draw solid conclusions about author self-citation trends in orthodontic literature
Overview of the Author Profiling Task at PAN 2013
No full text[EN] This overview presents the framework and results for the Author Profiling
task at PAN 2013. We describe in detail the corpus and its characteristics,
and the evaluation framework we used to measure the participants performance to
solve the problem of identifying age and gender from anonymous texts. Finally,
the approaches of the 21 participants and their results are described.The author profiling task @PAN-2013 was an activity of the WIQ-EI IRSES project (Grant No. 269180) within the FP 7 Marie Curie People Framework of the European Commission. We want to thank the Forensic Lab of the Universitat Pompeu Fabra Barcelona for sponsoring the award for the winner team. The work of the first author was partially funded by Autoritas Consulting SA and by Ministerio de Economía y Competitividad de España under grant ECOPORTUNITY IPT-2012-1220-430000. The work of the second author was in the framework the DIANA-APPLICATIONS-Finding Hidden Knowledge in Texts: Applications (TIN2012-38603-C02-01) project, and the VLC/CAMPUS Microcluster on Multimodal Interaction in Intelligent Systems. The work of fifth author was funded in part by the Swiss National Science Foundation (SNF) project "Mining Conversational Content for Topic Modelling and Author Identification (ChatMiner)" under grant number 200021_130208.Rangel, F.; Rosso, P.; Koppel, M.; Stamatatos, E.; Inches, G. (2013). Overview of the Author Profiling Task at PAN 2013. CLEF Conference on Multilingual and Multimodal Information Access Evaluation. 352-365. https://riunet.upv.es/handle/10251/46636S35236
Author Co-Citation Analysis (ACA): a powerful tool for representing implicit knowledge of scholar knowledge workers
No full textIn the last decade, knowledge has emerged as one of the most important and valuable organizational assets. Gradually this importance caused to emergence of new discipline entitled ―knowledge management‖. However one of the major challenges of knowledge management is conversion implicit or tacit knowledge to explicit knowledge. Thus Making knowledge visible so that it can be better accessed, discussed, valued or generally managed is a long-standing objective in knowledge management. Accordingly in this paper author co- citation analysis (ACA) will be proposed as an efficient technique of knowledge visualization in academia (Scholar knowledge workers)
Semana Santa y su simbología. 5 Segunda época Año 3 (2019) enero-junio. Rutas de Campo. Trabajo de Campo: Iztapalapa: memoria y cultura
No full textLos dos grandes momentos en torno a los cuales gira la cosmovisión católica, el nacimiento de Jesús y su muerte, han dado lugar, el primero, a la celebración de la Navidad, y el segundo, a la conmemoración de Semana Santa. En este texto nos ocuparemos de los años finales de la vida de Jesús, pues es precisamente Semana Santa la celebración litúrgica con que se recuerda su Pasión y su muerte. Recordemos que, en este contexto, el término “pasión” hace referencia al sufrimiento y a la serie de tormentos a que fue sometido Jesús poco antes de su muerte en la cruz, que todos conocemos.Altamirano, Ignacio Manuel (1974). Paisajes y leyendas. Tradiciones y costumbres de México. México: Porrúa.Calendario de fiestas tradicionales (1988). México: Dirección General de Culturas Populares-SEP.Calendario Litúrgico Pastoral 1991 (1990). México: Obra Nacional de la Buena Prensa.Campos, Rubén M. (1929). El folklore literario en México. Investigación de la producción literaria popular. México: Talleres Gráficos de la Nación._____ (1958). “Semana Santa”. En Fiesta. México: Talleres de la Secretaría de Hacienda.Castelló Iturbide, María Teresa (1958). “El altar del Viernes de Dolores”. En Fiesta. México: Talleres de la Secretaría de Hacienda.Catalán Blanco, Juan Carlos (s.f.). “Las fiestas de carnestolendas y la celebración de la Semana Santa en la época colonial” [inédito]. s.l.: Dirección General de Culturas Populares de Guerrero-SEP.Cid, Carlos, y Manuel Riu (1965). Historia de las religiones. Barcelona: Sopena._____ (1987). Compendio de historia sagrada y de la historia de la Iglesia. México: Progreso.Crumrine N., Roos (1979). “Cuaresma”. En Gran Enciclopedia Rialp. Madrid: Rialp.Estrada, Genaro (1945). Visionario de la Nueva España. México: Patria.Estrada, Humberto (1985). “La cuaresma” [inédito]. s.l.: Dirección General de Culturas Populares-SEP.Foster, George M. (1962). Cultura y conquista. Xalapa: Universidad Veracruzana.García Cubas, Antonio (1945). El libro de mis recuerdos. México: Patria.González Obregón, Luis (1936). Croniquillas de la Nueva España. México: Botas.____(1941). Las calles de México. México: Botas.Horcasitas, Fernando (1974). El teatro náhuatl: época novohispana y moderna. México: IIH-UNAM.Iglesias y Cabrera, Sonia C. (1996). Tradiciones de Cuaresma y Semana Santa. México: Museo Nacional de Culturas Populares-Dirección General de Culturas Populares._____ (2001). La semana Santa en México. Con la muerte en la cruz. México: Dirección General de Culturas Populares.Lercaro, Giacomo (1960). ¿Cuál es el vocabulario de la liturgia católica? México: Novaro.Macgowan, Kenneth, y William Melnitz (1964). Las edades de oro del teatro. México: FCE.Mendieta, Gerónimo de (1945). Historia eclesiástica indiana. México: Salvador Sánchez.Mendoza, Vicente T., y Adalberto Fuentes Cruz (1945). “Drama de la Pasión intitulado: el drama del Gólgota, que se representa en la delegación de Milpa Alta, D.F.”. Anuario de la Sociedad Folklórica de México, 6.Moreno Toscano, Alejandra (1981). “La conquista espiritual”. En Historia general de México. México: El Colegio de México.Olavarría Ferrari, Enrique de (1953). “Pasión de Cristo”. En Enciclopedia de la religión católica [t. V]. Barcelona: Dalma y Jovier._____ (1961). Reseña del teatro en México. México: Porrúa.Pike E., Royston (1986). Diccionario de religiones. México: FCE.Prieto, Guillermo (1969). Memorias de mis tiempos. México: Patria.Rodríguez, Mariángela (1991). Hacia la estrella con la Pasión y la ciudad a cuestas. Semana Santa en Iztapalapa. México: Ediciones de la Casa Chata-CIESAS.Sociedad Bíblica Británica y Extranjera de Londres (1929). La Santa Biblia. Londres: SBBEL.Vetancurt, Agustín de (1941). Teatro mexicano: descripción breve de los sucesos exemplares de la Nueva España en el mundo occidental de las Indias. Madrid: J. Porrúa.Verti, Sebastián (1991). Tradiciones mexicanas. México: Diana.Weckmann, Luis (1984). La herencia medieval de México. México: FCE
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