117 research outputs found
Interview: The Uniqueness and Continuing Relevance of Gabriel Marcel
No full textThe interview of Tudor Petcu with Brendan Sweetman. Brendan Sweetman is a teacher, philosopher, and writer. From Dublin, Ireland, he is Professor of Philosophy and holds the Sullivan Chair in Philosophy at Rockhurst University, Kansas City, Missouri, USA. He is the author or editor of twelve books, including Religion and Science: An Introduction (Continuum, 2010), The Vision of Gabriel Marcel (Rodopi, 2008), Religion: Key Concepts in Philosophy (Continuum, 2007), Why Politics Needs Religion: The Place of Religious Arguments in the Public Square (InterVarsity, 2006), Contemporary Perspectives on Religious Epistemology (Oxford U.P., 1992), A Gabriel Marcel Reader (St. Augustine’s Press, 2011), and, most recently, Evolution, Chance, and God (Bloomsbury, 2015). He has published more than one hundred articles and critical reviews in a variety of journals, collections, and reference works, including International Philosophical Quarterly, American Catholic Philosophical Quarterly, Faith and Philosophy, Philosophia Christi, Philosophical Quarterly, Review of Metaphysics, Stanford Encyclopedia of Philosophy, The Polish Encyclopedia of Philosophy, and New Catholic Encyclopedia (for which he was a Consulting Editor). He has been a Visiting Scholar and Keynote Speaker at several universities and colleges in the U.S., and, internationally, has given lectures in many countries. Dr Sweetman is the current President of the Gabriel Marcel Society, Vice-President for North America of World Conference of Catholic University Institutions of Philosophy (COMIUCAP), and the editor of Marcel Studies. His books and articles have been translated into several languages, including Portuguese and Italian
The myogenic regulatory factors: critical determinants of muscle identity in development, growth and regeneration
No full textThe book ‘Skeletal Muscle – From Myogenesis to Clinical Relations’ offers a wide range of topics related to the skeletal muscle morphology and function. Chapters deal with the process of myogenesis and the regeneration of skeletal muscle as well as the morphological and functional changes on the effect of exercise or disuse. Implementation of molecular biology techniques in the investigations reveals new perspective in the understanding of skeletal muscle disorders. The deeper exploration of the neuromuscular signal transduction and modification offers more stable basis for clinical interventions. The section ‘Clinical relations’ highlights the background of altered muscle function in some types of myopathies and diabetes mellitus. The book is recommended to scientists, clinicians and students in the field of medical and health sciences as well as the readers who are interested in the proliferation and differentiation processes
Memory, tradition, and Christianization of the Peloponnese
No full textThis work examines the use of memory and tradition in the Christianization of the Peloponnese based on the evidence of the location and topography of churches. The different processes of conversion in the area have already been discussed, and the focus of this work is to show the extent of continuation of religious practice from the Roman to Late Antique periods. A diachronic analysis of the evidence for towns and sanctuaries from the fourth to seventh centuries is presented. It is argued that throughout the different Christianization processes memory and tradition were managed by the church in terms of its location, architecture, and rituals. It is likely that the church consciously maintained certain traditions of place, imagery, and action in order to retain and use memory traces from the established religious structures, which helped situate the Christian church as a central element of community life and identity. Therefore, it is contended that an essential element of the Christianization process was to maintain earlier memories and traditions not only to enable an efficiently unobtrusive conversion for its long-term success but also to ensure the maintenance of existing social structures, which in turn sustained the church.Peer reviewe
The use of a viral 2A sequence for the simultaneous over-expression of both the vgf gene and enhanced green fluorescent protein (eGFP) in vitro and in vivo
No full textCopyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved. Open Access funded by Biotechnology and Biological Sciences Research Council Acknowledgements We would like to thank Dr Dylan Sweetman for his invaluable help and advice with regards to the in situ hybridisation work. The work was supported by University of Nottingham Knowledge Transfer Award and the BBSRC Strategic Skills Award.Peer reviewe
Many routes to the same destination:lessons from skeletal muscle development
No full textThe development and differentiation of vertebrate skeletal muscle provide an important paradigm to understand the inductive signals and molecular events controlling differentiation of specific cell types. Recent findings show that a core transcriptional network, initiated by the myogenic regulatory factors (MRFs; MYF5, MYOD, myogenin and MRF4), is activated by separate populations of cells in embryos in response to various signalling pathways. This review will highlight how cells from multiple distinct starting points can converge on a common set of regulators to generate skeletal muscle
The role of spalt proteins in development and disease
No full textThe spalt proteins are encoded by a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans and vertebrates. In humans, mutations in some of these genes are associated with several congenital disorders which underscores the importance of spalt gene function in embryonic development. Recent studies have begun to cast light on the functions of this family of proteins with increasing understanding of the developmental processes regulated and the molecular mechanisms used. Here we review what is currently known about the role of spalt genes in vertebrate development and human disease
Automated collection and categorisation of STM images and STS spectra with and without machine learning
No full textAtomic resolution scanning probe microscopy, and in particular scanning tunnelling microscopy (STM) allows for high-spatial-resolution imaging and also spectroscopic analysis of small organic molecules. However, preparation and characterisation of the probe apex in situ by a human operator is one of the major barriers to high-throughput experimentation and to reproducibility between experiments. Characterisation of the probe apex is usually accomplished via assessment of the imaging quality on the target molecule and also the characteristics of the scanning tunnelling spectra (STS) on clean metal surfaces. Critically for spectroscopic experiments, assessment of the spatial resolution of the image is not sufficient to ensure a high-quality tip for spectroscopic measurements. The ability to automate this process is a key aim in development of high resolution scanning probe materials characterisation. In this paper, we assess the feasibility of automating the assessment of imaging quality, and spectroscopic tip quality, via both machine learning (ML) and deterministic methods (DM) using a prototypical tin phthalocyanine on Au(111) system at 4.7 K. We find that both ML and DM are able to classify images and spectra with high accuracy, with only a small amount of prior surface knowledge. We highlight the practical advantage of DM not requiring large training datasets to implement on new systems and demonstrate a proof-of-principle automated experiment that is able to repeatedly prepare the tip, identify molecules of interest, and perform site-specific STS experiments using DM, in order to produce large numbers of spectra with different tips suitable for statistical analysis. Deterministic methods can be easily implemented to classify the imaging and spectroscopic quality of a STM tip for the purposes of high-resolution STM and STS on small organic molecules. Via automated classification of the tip state, we demonstrate an automated experiment that can collect a high number of spectra on multiple molecules without human intervention. The technique can be easily extended to most metal–adsorbate systems and is promising for the development of automated, high-throughput, STM characterisation of small adsorbate systems
A fresh start for screening under the Habitats Regulations: Case c-323/17 People Over Wind, Peter Sweetman v Coillte Teoranta [2018] Ecr I-244
No full textThis is the author accepted manuscript. The final version is available from SAGE Publications via the DOI in this recordFor over twenty-five years, the courts have been delivering judgments that shape and refine the requirements of the Habitats Directive. The recent CJEU judgment of People Over Wind, Peter Sweetman v Coillte Teoranta [2018] ECR I-244 provides further clarification that will keep developers and decision-makers on their toes. In the judgment delivered in April 2018, the sole question for the court was whether, or in what circumstances, mitigation measures can be considered when carrying out screening for appropriate assessment under Article 6(3) of the Habitats Directive? The court’s response to this question is significant. In a confident judgment, it was held that mitigation measures cannot be considered when carrying out screening for appropriate assessment. This case note provides a detailed overview of the judgment, followed by an analysis of the extent to which the decision is consistent with existing case law authority in England. Finally, this commentary concludes with a consideration of the potential implications that the ruling may have on developers and decision-makers
microRNAs in skeletal muscle differentiation and disease
No full textmiRNAs (microRNAs) are novel post-transcriptional regulators of gene expression. Several miRNAs, expressed exclusively in muscle, play important roles during muscle development, growth and regeneration; other ubiquitously expressed miRNAs are also essential for muscle function. In the present review, we outline the miRNAs involved in embryonic muscle development and those that have been found to be dysregulated in diseases associated with skeletal muscle or are changed during muscle adaptation. miRNAs are promising biomarkers and candidates for potential therapeutic intervention. We discuss the strategies that aim to develop novel therapies through modulating miRNA activity. In time, some of these approaches may become available to treat muscle-associated diseases
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