202,141 research outputs found
Charles Dutton, Henrietta Edmonds, c1990s.
No full textUnknown student (L), actor Charles S. Dutton (M), and Howard University professor Henrietta (Henri) Edmonds, c1990s.https://dh.howard.edu/africana_photos/1014/thumbnail.jp
Unpacking the Deterrent Effect of the International Criminal Court: Lessons from Kenya
No full textProfessor Yvonne M. Dutton, of Indiana University Robert H. McKinney School of Law, presented a working draft of her work Unpacking the Deterrent Effect of the International Criminal Court: Lessons from Kenya. This work examines combined with documentary data about what happened in Kenya before and after it ratified the Rome Statute—with a specific focus on those who have been targeted by the ICC—, a new model for evaluating and understanding the ICC’s deterrent power.https://ecollections.law.fiu.edu/faculty-workshops/1011/thumbnail.jp
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A cross species metabolomics analysis on the effect of biological stressors such as depression and sleep loss on the host metabolome
No full textIt would be next to impossible to list the many people who have supported and helped me get to where I am today. My trajectory from birth to graduate school has not been linear. I have always had a natural curiosity about the world around me; starting from my time growing up as an illegal immigrant in the city of Los Angeles, to my time served as rifleman in the United State Marine Corps, and my current position as a scientist. The richness of these experiences has had a profound influence on the way I approach life. Through it all, Patricia, my mother, sacrificed everything and made this possible. Cristina, my younger sister, has been a constant reminder that I have an obligation as an older brother to make her proud. Arpa, my love and joy, has walked this crucible called graduate school next to me, and has been a constant source of love and encouragement. To the three most important people in my life, thank you for everything. My success as a scientist can be attributed to the various scientist I can call mentors and friends. Professor Jamil Momand, my undergraduate advisor and research mentor, introduced me to the field of biochemistry and encourage me to pursue my Ph.D.. Thank you for your guidance and support. Professor Pieter C. Dorrestein, my Ph.D mentor, provided me with a once in a life time experience graduate education in mass spectrometry and its application in life sciences. I cannot express how thankful I am for your mentorship, guidance, and support. The environment that you have cultivated in the Dorrestein lab provided me with the tools and opportunities to grow and succeed as a researcher. I will always appreciate everything that you have done for me. I would also like to thank my committee members for their role in my graduate education, thank you Professor Rob Knight, Professor Rachel Dutton, Professor Susan S. Golden, and Professor Jose Pruneda-Paz.Chapter 2, in full, is a reprint of the material as it appears in Journal of The American Society for Mass Spectrometry 2019. da Silva, R. R; Vargas, F; Ernst, M; Nguyen, N. H; Bolleddu, S; del Rosario, K. K; Tsunoda, S. M; Dorrestein, P. C; Jarmusch, A. K.; Springer US, 2018. The dissertation author was a primary investigator and author of this paper. Chapter 3, in full, has been submitted for publication of the material as it may appear in Rapid Communications in Mass Spectrometry, 2019, Vargas, F; Weldon, K. C; Sikora, N; Wang, M; Zhang, Z; Gentry, E. C; Panitchpakdi, M. W; Caraballo, M; Dorrestein, P. C; Jarmusch, A. K.; John Wiley & Sons, 2019. The dissertation author was the primary investigator and author of this paper. Chapter 4, in full, has been submitted for publication of the material as it may appear in Frontiers in Psychiatry, 2019, Vargas, F; Dethloff, F; Emmanuel, E; Quinn, R; Park, D. I; Herzog, D. P, Müller, M. B; Gentry, E. C; Knight, R; Gonzalez, A; Dorrestein, P. C; Turck, C. W.; Frontiers Media, 2019. The dissertation author was the primary investigator and author of this paper. Chapter 5, in full, has been submitted for publication of the material as it may appear in Scientific Reports, 2019, Thompson, R. S; Vargas, F; Dorrestein, P. C; Chichlowski, M; Berg, B. M; Fleshner, M.; Nature Publishing Group, 2019. The dissertation author was a primary investigator and author of this paper. Chapter 6, in full, has been submitted for publication of the material as it may appear in Sleep, 2019, Bowers, S. J; Vargas, F; Gonzalez, A; He, S; Jiang, P; Dorrestein, P. C; Knight, R; Wright, K. P; Lowry, C. A; Fleshner, M; Vitaerna, M. H; Turek, F. W.; Oxford University Press, 2019. The dissertation author was a primary investigator and author of this paper
Investigating the role of the B-cell receptor in mantle cell lymphoma
No full textMantle cell lymphoma (MCL) is a mature B-cell lymphoma typically characterised by the expression of cluster of differentiation 5 (CD5) and a t(11;14) translocation resulting in overexpression of cyclins. MCL displays significant morphological and clinical heterogeneity. Like chronic lymphocytic leukaemia (CLL), MCL can be divided into two subsets based upon immunoglobulin heavy chain variable (IGHV) region status: the more common unmutated (U-) IGHV and less common mutated (M-) IGHV subset. It has been suggested that, like in CLL, IGHV status informs different origin and clinical behaviour, with U-MCL being of pre-germinal centre (pre-GC) origin and aggressive clinical behaviour and M-MCL of post-GC origin and indolent course.In CLL, B-cell receptor (BCR) levels and signalling capacity have also helped to define subgroups with important clinical and biological significance. This thesis aimed to extend investigations to the BCR of MCLs and understand if BCR expression and signalling variation in MCL could affect variation in clinical behaviour.A cohort of thirty-six MCL cases were assessed for immunogenetic, phenotypic and functional characteristics including signalling capacity. IGHV3-21 and 4-34 were equally identified in U-MCL whilst IGHV4-34 was most common in M-MCL. Fifty percent (%) had an U-IGHV (>98% homology to germline). Surface immunoglobulin (sIg) M was expressed variably but significantly higher in conventional, nodal MCL (p=0.01) and non-aggressive U-MCL (p=0.03) than in leukaemic non-nodal (LNN) or M-MCL.Surface IgM (sIgM) expression was higher in MCL than in CLL (p<0.01). Mean signalling capacity was significantly higher in MCL than CLL (p<0.01), and correlated positively with sIgM expression. A subgroup of MCL had low signalling capacity similar to CLL. This ‘CLL-like’ signalling group was composed predominantly of LNN MCL and IGHV3-21 U-MCL with low sIgM expression. In contrast to high signalling MCL cases, this group had a CLL-like BCR engaged functional phenotype: recoverable sIgM expression in vitro, high basal proximal signalling kinases and an ‘activated’ glycosylation profile on the constant Ig region.MCL tissue and matched lymph node and peripheral blood samples were assessed. The lymph node compartment was identified as the likely site of engagement in non-aggressive MCL; sIgM levels were significantly lower in the lymph node than in the peripheral blood in all tissue and paired samples (p=0.03). Signalling capacity was also significantly lower in lymph node tissue samples (p<0.01). Lower sIgM levels in the lymph node may be indicative of site occurred antigen-induced endocytosis. M-MCL with low sIgM was associated with improved event-free survival (p=0.04).This study reveals that a proportion of MCL have a BCR engaged signature with low sIgM and low signalling capacity. This likely occurs in the lymph node compartment as a result of the influence of putative (super)antigen, with down-modulation of sIgM. This is particularly prominent in LNN M-MCL and may affect the balance between proliferation and anergy. This mirrors other mature B-cell malignancies, particularly CLL, where this interaction influences clinical outcomes
Applications of Phase Change Material - Integrated Hybrid HVAC Systems in Commercial Buildings (Session 7 of 10)
No full textThis presentation, provided by the Building Efficiency for a Sustainable Tomorrow (BEST) Center, is from the BEST Center's 2022 Annual Institute. During the presentation, Spencer Dutton, principle scientific engineering associate at the Lawrence Berkley National Laboratory, discusses the development of an all-electric HVAC system with integrated thermal energy storage. The thermal storage allows shifts in energy use from peak high cost periods to off peak periods were renewable energy is available. Dutton discusses topics such as commercialization of the HVAC system, software tools used, the installation of the prototype, and more.This video runs 29:39 minutes in length. Additional videos from the BEST Center's 2022 Institute are available to view separately
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
Inter-agency Cooperation and New Approaches to Employability
No full textThis article examines the role of inter-agency cooperation, which is one form of ‘partnership’, in new approaches to employability in the UK. The article articulates a ‘model for effective partnership working’ on employability. This model is applied first in a general review of employability policy and then to discuss case study research on the recent ‘Pathways to Work’ and ‘Working Neighbourhoods’ pilots. It is argued that successful partnerships need a clear strategic focus based on a necessity for inter-agency cooperation and institutional arrangements that allow for shared ownership, trust and mutualism, and flexibility in resource-sharing. While some of these factors are apparent in UK employability services, an over-reliance on contractualism and centralized organizational structures may undermine partnership-based approaches. Many of the success factors associated with effective partnership working appeared to be in place, even though the role of the Public Employment Service was fundamentally different in each case (as a key actor in implementing the first pilot, but largely withdrawing from the implementation role in the second). The article concludes by outlining the relevance of this model and the case study findings to discussions of the future development of employability policies and related partnership working
Advances in Anesthesia, Vol. 37
No full textMcLoughlin Jr, T. M., Dutton, R. P., Salinas, F. V., Torsher, L. C. (Eds.). (2019). Advances in Anesthesia, Vol. 37. Philadelphia: Elsevier
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