3,296 research outputs found
Sixty Years of Community: St. Olaf Catholic Parish in Eau Claire, Wisconsin, 1952-2012
No full textThis paper will explore how the parish community of St. Olaf in Eau Claire, Wisconsin, established in 1952, reflects the Roman Catholic Church, specifically at the local, state, and national levels in the United States. It will also discuss the various changes that have occurred in the past 60 years of its history in terms of the various locations of worship for the members, the growth of the community outreach programs, and the effects of the Second Vatican Council. This ecumenical council was a meeting of Catholic bishops from around the whole that brought reform to the Catholic Church and affected the relationship of the Catholic Church to the world. The parish at St. Olaf has grown from having only 125 families in 1952 to over 1,000 families in 2012
From Mansions to Towers: A History of Residence Halls at the University of Wisconsin-Eau Claire
No full textThe construction of the University of Wisconsin-Eau Claire's residence halls has generally followed that of the national trend. The school struggled to find enough funds to build residence halls in the early years. Eventually, student housing was in needed so badly that the school had no choice but to provide housing for the students. In 1947, the Dulany mansion was purchased and remodeled by the school. This building served as the University's first resident hall. Since then, eleven resident halls have been built on campus with one more being planned. Life in these residence halls have changed dramatically over time. In the 1960's, the students protested and eventually the strict rules of in loco parentis faded away. After this, students enjoyed the freedoms of new technologies, relaxed rules, and more professional housing leaders. Today, UW-Eau Claire is a thriving university. UW-Eau Claire has been recognized by many as a top school in the Midwest. Much of the success can be attributed to the residence halls and the happiness of the students. My paper will provide UW-Eau Claire and its students with a cohesive history of the residence halls on campus and will also show how student life has evolved since the University was first established
Claire Tham (1967-)
No full textAs an author, Claire Tham has this far been less concerned to observe the canons of English literature and more concerned to explore its creative possibilities and its adaptability. She also articulates a significant viewpoint about national and personal identity, about cultural tensions in a dynamic urban centre in transition, and about the.flip-side of Singapore’s prodigious prosperity
Confirmation of p-tau Ser356’s association with Alzheimer’s disease pathology and lowering in response to WZ4003 treatment in brain slice cultures. Reply to: “Phospho-tau Ser356 is mostly confined to pre-NFT neurons in Alzheimer’s pathology”
No full textThis dataset relates to correspondence by Taylor et al. Here we repeat some key experiments from Taylor et al 2024 using the more more specific antibody ab92682. We find that the core findings from our original Taylor et al 2024 paper are robust and reproducible. Using the more specific ab92682 antibody we find that: 1. P-tau Ser356 increases in a Braak stage-dependent manner in human post-mortem temporal cortex (western blot); 2. P-tau Ser356 co-localises with methoxy positive tangles in AD post-mortem brain (both in paraffin sections and using array tomography); 3. P-tauSer356 co-localises with pre-synaptic terminals and astrocytic processes in AD post-mortem brain (array tomography); 4. P-tau Ser356 levels are lowered in response to treatment with the NUAK1/2 inhibitor WZ4003 in live brain slice cultures (mouse organotypic brain slice cultures)
Claire Wheeler: Fearless Psychologist
No full textFearless physician/psychologist Claire is a clinical psychologist and former emergency room doctor. As a full-time instructor at PSU’s School of Community Health she teaches classes in disease physiology, mind-body medicine, nutrition and health psychology. She is the author of 10 Simple Solutions to Stress, published in 2007. She’ll reveal some of the mysteries of how negative thoughts can affect your health, and teach techniques to avoid them. Think “cognitive reframing.”https://pdxscholar.library.pdx.edu/pdxtalks/1020/thumbnail.jp
Jurisprudence - the bystander to crime
No full textThe author raises questions about the predicament of a bystander to a serious crime who does not intervene to oppose it. Article by Claire Valier (Lecturer in Law, University of London) published in Amicus Curiae - Journal of the Society for Advanced Legal Studies. The Journal is produced by the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies, University of London
La Fabrique des classiques africains: écrivains d’Afrique subsaharienne francophone . Par Ducournau Claire
No full textThis is a pre-copyedited, author-produced PDF of an article accepted for publication in French Studies following peer review. The version of record Claire H Griffiths (2018) La Fabrique des classiques africains : ecrivains d'Afrique subsaharienne francophone par Claire Ducournau, French Studies, Volume 72, Issue 2, 1 April 2018, Pages 318–319 is available online at: https://doi.org/10.1093/fs/kny023The review article evaluates major new scholarship on the development of the French literary system in colonial and postcolonial Africa and its impact on Francophone writing
p-tau Ser356 is associated with Alzheimer’s disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003
No full textTau hyperphosphorylation and aggregation is a common feature of many dementia-causing neurodegenerative diseases. Tau can be phosphorylated at up to 85 different sites, and there is increasing interest in whether tau phosphorylation at specific epitopes, by specific kinases, plays an important role in disease progression. The AMP-activated protein kinase (AMPK)-related enzyme NUAK1 has been identified as a potential mediator of tau pathology, whereby NUAK1-mediated phosphorylation of tau at Ser356 prevents the degradation of tau by the proteasome, further exacerbating tau hyperphosphorylation and accumulation. This study provides a detailed characterisation of the association of p-tau Ser356 with progression of Alzheimer’s disease pathology, identifying a Braak stage-dependent increase in p-tau Ser356 protein levels and an almost ubiquitous presence in neurofibrillary tangles. We also demonstrate, using sub-diffraction-limit resolution array tomography imaging, that p-tau Ser356 co-localises with synapses in AD postmortem brain tissue, increasing evidence that this form of tau may play important roles in AD progression. To assess the potential impacts of pharmacological NUAK inhibition in an ex vivo system that retains multiple cell types and brain-relevant neuronal architecture, we treated postnatal mouse organotypic brain slice cultures from wildtype or APP/PS1 littermates with the commercially available NUAK1/2 inhibitor WZ4003. Whilst there were no genotype-specific effects, we found that WZ4003 results in a culture-phase-dependent loss of total tau and p-tau Ser356, which corresponds with a reduction in neuronal and synaptic proteins. By contrast, application of WZ4003 to live human brain slice cultures results in a specific lowering of p-tau Ser356, alongside increased neuronal tubulin protein. This work identifies differential responses of postnatal mouse organotypic brain slice cultures and adult human brain slice cultures to NUAK1 inhibition that will be important to consider in future work developing tau-targeting therapeutics for human disease. This dataset refers to the publication ( https://doi.org/10.1007/s00401-023-02667-w )
Why hedge? Extent, nature, and determinants of derivative usage in U.S. municipalities
No full textUsing a hand-collected dataset of over 300 observations of large U.S. cities and counties, this paper investigates the extent, nature and determinants of derivatives usage in the municipal sector.Over half of our sample entities engage in derivative transactions and a vast majority of these transactions are intended to manage interest rate risk. Swaps, by far, are the most popular derivative instrument. In terms of the determinants of derivative usage,we find that the propensity to use derivatives as well as the extent of derivative usage is higher for municipalities that are larger and more financially constrained. We do not find growth to be related to municipal derivative usage. Contrary to suggestions made in the popular press, we fail to find managerial opportunism to be a significant factor in municipal derivative usage. We also find that more sophisticated managers of large municipalities and less sophisticated managers of small municipalities are more likely to engage in derivative transactions.Peer reviewe
Capital asset accounting policies under GASB Statement No. 34: Characteristics, antecedents, and implications
No full textIn this paper, we study the evolution of state and local governments’ capital asset accounting policies from the adoption of GASB Statement No. 34 through the fiscal year ending in 2016. We document substantial cross-sectional and time-series variation in the capitalization thresholds and estimated useful lives pertaining to major classes of capital assets, including buildings, equipment, improvements, and infrastructure assets. Diversity in capital asset accounting policies potentially diminishes the comparability of capital asset accounting information across governments and over time. We also discuss matters related to the implementation and ongoing use of the modified approach for reporting infrastructure assets. Our findings are useful to the GASB as well as to users of government financial reports.Peer reviewe
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