266 research outputs found
A Century of Mathematical Excellence at Spelman College
No full textThis file consists of the presentation slides of a presentation by Colm Mulcahy at the AMS-NAM Joint Special Session on The Mathematics of the Atlanta University Center. The event was held Thursday January 5, 2017, 8:00 a.m.-4:00 p.m. at the Marriott Marquis in Atlanta, Georgia. KEYWORDS: Mathematics, Spelman College, Histor
Liquid-phase monolayer doping of InGaAs with Si-, S-, and Sn-containing organic molecular layers
No full textThe functionalization and subsequent monolayer doping of InGaAs substrates using a tin-containing molecule and a compound containing both silicon and sulfur was investigated. Epitaxial InGaAs layers were grown on semi-insulating InP wafers and functionalized with both sulfur and silicon using mercaptopropyltriethoxysilane and with tin using allyltributylstannane. The functionalized surfaces were characterized using X-ray photoelectron spectroscopy (XPS). The surfaces were capped and subjected to rapid thermal annealing to cause in-diffusion of dopant atoms. Dopant diffusion was monitored using secondary ion mass spectrometry. Raman scattering was utilized to nondestructively determine the presence of dopant atoms, prior to destructive analysis, by comparison to a blank undoped sample. Additionally, due to the As-dominant surface chemistry, the resistance of the functionalized surfaces to oxidation in ambient conditions over periods of 24 h and 1 week was elucidated using XPS by monitoring the As 3d core level for the presence of oxide components
Short Stories, Novels and Spain. An Interview With Colm Tóibín
No full textColm Tóibín (Enniscorthy, 1955) is the author of five novels, The South (1990), The Heather Blazing (1992), The Story of the Night (1996), The Blackwater Lightship(1999) and The Master (2004). This last novel won the IMPAC Dublin Literary Award, the Los Angeles Times Novel of the Year, the Prix du Meilleur Livre Etranger for the best foreign novel published in 2005 in France, and it was shortlisted for the Man Booker Prize. Colm Tóibín has a long career in journalism and was the editor of the magazine Magill from 1982 to 1985. He is also the author of several non-fiction books, including Homage to Barcelona (1990) and The Sign of the Cross: Travels in Catholic Europe (1994). He edited The Penguin Book of Irish Fiction (1999) and has recently published his first book of short stories,Mothers and Sons (2006). Colm Tóibín attended the 10th International Conference on the Short Story in English, held at University College Cork on 19-21 June 2008, where this interview took place
A Guest at the Feast
No full textColm Tóibín\u27s touching memoir, A Guest at the Feast, beautifully read by the author himself. A Guest at the Feast moves from the small town of Enniscorthy to Dublin, from memories of a mother who always had a book on the go to the author\u27s early adulthood, from a love of literature to the influences of place and family. Tóibín\u27s captivating memoir is the story of a writer coming of age and his connections between home, work and love. It is a perfect gem of a book.https://corescholar.libraries.wright.edu/dlpp_all/1452/thumbnail.jp
Making-with, Making-do: Constellations of Concepts and Practices around Adaptive Reuse
No full textEvery demolition is an act of violence with devastating ecological and cultural repercussions that reverberate for generations. Responding to a reality in which not just buildings but even entire communities are treated as disposable, this research supports and advances adaptive reuse as a more sustainable alternative to wasteful construction models based on demolition and reconstruction. To do so, it engages not only with the material, technical and economic aspects of reusing existing buildings, but also with the wider historical, political and socio-cultural contexts that influence and shape every architectural act.
Representing an exercise in sympoiesis or ‘making-with’, the project deliberately positions itself between practice and research. Through engaging in conversation with a range of practitioners and thinkers, it emphasises how adaptive reuse blurs authorial boundaries – not just across time, through working with previous and future authors, but also across space, as more collaborative modes of practice question previously accepted notions of a single, autonomous author-architect.
The project’s three-part outcome comprises an open-access web platform www.adaptreuse.org, the main thesis publication and a handbook for practitioners.
The thesis represents a literary practice of adaptive reuse, a polyform and polyphonic exploration that embodies and performs the ideas it explores. Instead of attempting to develop a universal, fixed theoretical framework, the thesis takes a weak theory approach: it configures a collection of diverse fragments into an open, relational and generative constellation that accommodates rather than resolves difference. Bending time and space, this constellation challenges linear narratives to illuminate and reveal insights across disparate spacetimes.
Through a reparative reading of several key examples, the accompanying handbook offers students and practitioners a set of verbs or lemmas that can be conjugated differently according to the specific context or situation. These lemmas represent concrete, transformative actions that can be translated not only across different projects, but also different disciplines.
The critical contribution of the project lies in how it creates new possibilities for the wider discipline of architecture by expanding its existing vocabulary and concepts, offering alternative ways of viewing and engaging with the world, and therefore of constructing it.The members of the doctoral jury were Dr. Kate Briggs, Dr. Elke Couchez, Arch. Ing. Jan Haerens, Dr. Catalina Mejía Moreno, Prof. Dr. Kris Pint, Dr. Mia You
Making-with, Making-do: Constellations of Concepts and Practices around Adaptive Reuse
No full textEvery demolition is an act of violence with devastating ecological and cultural repercussions that reverberate for generations. Responding to a reality in which not just buildings but even entire communities are treated as disposable, this research supports and advances adaptive reuse as a more sustainable alternative to wasteful construction models based on demolition and reconstruction. To do so, it engages not only with the material, technical and economic aspects of reusing existing buildings, but also with the wider historical, political and socio-cultural contexts that influence and shape every architectural act.
Representing an exercise in sympoiesis or ‘making-with’, the project deliberately positions itself between practice and research. Through engaging in conversation with a range of practitioners and thinkers, it emphasises how adaptive reuse blurs authorial boundaries – not just across time, through working with previous and future authors, but also across space, as more collaborative modes of practice question previously accepted notions of a single, autonomous author-architect.
The project’s three-part outcome comprises an open-access web platform www.adaptreuse.org, the main thesis publication and a handbook for practitioners.
The thesis represents a literary practice of adaptive reuse, a polyform and polyphonic exploration that embodies and performs the ideas it explores. Instead of attempting to develop a universal, fixed theoretical framework, the thesis takes a weak theory approach: it configures a collection of diverse fragments into an open, relational and generative constellation that accommodates rather than resolves difference. Bending time and space, this constellation challenges linear narratives to illuminate and reveal insights across disparate spacetimes.
Through a reparative reading of several key examples, the accompanying handbook offers students and practitioners a set of verbs or lemmas that can be conjugated differently according to the specific context or situation. These lemmas represent concrete, transformative actions that can be translated not only across different projects, but also different disciplines.
The critical contribution of the project lies in how it creates new possibilities for the wider discipline of architecture by expanding its existing vocabulary and concepts, offering alternative ways of viewing and engaging with the world, and therefore of constructing it.The members of the doctoral jury were Dr. Kate Briggs, Dr. Elke Couchez, Arch. Ing. Jan Haerens, Dr. Catalina Mejía Moreno, Prof. Dr. Kris Pint, Dr. Mia You
Silence and Familial Homophobia in Colm Tóibín’s “Entiendes” and “One Minus One”
No full textThe present study focuses on two of Colm Tóibín’s gay short-stories – “Entiendes” (1993) and “One Minus One” (2010) – in which the homosexual son meditates on his attachment to the dead mother. In both texts, Tóibín characterises the mother-son bond as being fraught with silence, resentment and lack of communication. In “One Minus One” and “Entiendes”, the son’s closeted homosexuality coexists with familial legacies of shame, uneasiness and duplicity. The central characters in the two texts are similar, as they experience the same type of existential exile, solitude and alienation derived from their complex attachments to home and family. As shall be explained, the author dwells on the damaging effects of familial homophobia, highlighting the limitations of the dominant heteronormative family model to accommodate gay sensibilities
Silence and familial homophobia in Colm Tóibín’s “Entiendes” and “One Minus One”
No full textThe present study focuses on two of Colm Tóibín’s gay short-stories – “Entiendes” (1993) and “One Minus One” (2010) – in which the homosexual son meditates on his attachment to the dead mother. In both texts, Tóibín characterises the mother-son bond as being fraught with silence, resentment and lack of communication. In “One Minus One” and “Entiendes”, the son’s closeted homosexu-ality coexists with familial legacies of shame, uneasiness and du-plicity. The central characters in the two texts are similar, as they experience the same type of existential exile, solitude and aliena-tion derived from their complex attachments to home and family. As shall be explained, the author dwells on the damaging effects of familial homophobia, highlighting the limitations of the dominant heteronormative family model to accommodate gay sensibilitiesAgencia Estatal de Investigación | Ref. FFI2017-84619-PXunta de Galicia | Ref. ED431D2017/1
Silence and Familial Homophobia in Colm Tóibín’s “Entiendes” and “One Minus One”
No full textThe present study focuses on two of Colm Tóibín’s gay short-stories – “Entiendes” (1993) and “One Minus One” (2010) – in which the homosexual son meditates on his attachment to the dead mother. In both texts, Tóibín characterises the mother-son bond as being fraught with silence, resentment and lack of communication. In “One Minus One” and “Entiendes”, the son’s closeted homosexuality coexists with familial legacies of shame, uneasiness and duplicity. The central characters in the two texts are similar, as they experience the same type of existential exile, solitude and alienation derived from their complex attachments to home and family. As shall be explained, the author dwells on the damaging effects of familial homophobia, highlighting the limitations of the dominant heteronormative family model to accommodate gay sensibilities
Abstract PR01: Blocking Colony Stimulating Factor 1 Receptor (CSF-1R) and Tropomyosin Receptor Kinase (Trk) improves antitumor efficacy of immunotherapy
No full textAbstract
The tumor microenvironment can provide a strong limitation to the antitumor activity of immunotherapy. Established tumors can escape immune responses by creating an inflammatory milieu that supports and recruits tumor-infiltrating myeloid cells (TIMs) with immune suppressive functions. Colony stimulating factor-1 (CSF-1) is a cytokine that is secreted by various cancer types including melanoma. It binds to colony stimulating factor-1 receptor (CSF-1R) on the myeloid cells. It stimulates the proliferation and recruitment of immunosuppressive M2-macrophages and myeloid derived suppressor cells (MDSC) into the tumor microenvironement. In addition, neurotrophins are a family of growth factors that includes nerve growth factor (NGF). NGF is the ligand for a family of tyrosine kinase receptors (Trks) that includes Trk-A, -B, and -C. Signal transduction through the Trk receptors regulates tumor growth. Trk receptors have been shown to be overexpressed in different cancer types. For example, Trk-C is overexpressed in 60% of patients with melanoma at various stages.
PLX7486 is a novel orally bioavailable small molecule Trk and CSF-1R dual-inhibitor that is now being studied in Phase I clinical trials. PLX7486 can target Trks directly on cancer cells and block myeloid cell recruitment to the tumor microenvironement through CSF-1R. We hypothesize that PLX7486 would synergize with immunotherapies to result in a greater antitumor effect by inhibiting the recruitment of immunosuppressive macrophages.
In order to block the Trk receptors on cancer cells with PLX7486, we first confirmed the expression of Trk receptors in murine cancer cell lines, such as MC38, SA1N, MB49, 4T1, B16F10, and 3LL. These cancer cell lines have also been exposed to PLX7486 with a broad range of concentrations (0.1 to 10 μM). We have shown that PLX7486 has a direct cytotoxic effect with IC50 of 5-8μM on most of the cancer cell lines at a 72 hour time point. Futher, the exposure of MC38 to PLX7486 resulted in the expected effects of inhibiting downstream AKT pathway signaling. In addition, PLX7486 has also been shown to have cytotoxic direct effect on bone marrow-derived macrophages and murine macrophage cell line RAW264.7 with IC50<1μM, including inhibition of the MAPK pathway. In order to test whether PLX7486 is toxic to T-cells, pmel-1/Thy1.1+ T-cells were adoptively transferred into mice, which then received daily oral gavage with PLX7486 (20mg/kg) for 5 days. Interestingly, the amount of pmel-1/Thy1.1+ T-cells increased in the spleen (vehicle: 1.76±0.2%, PLX7486: 3.52±0.4%). We then tested the combination of PLX7486 and immunotherapy reagents such as anti-CTLA-4 and anti-PD-1 in vivo in MC38 and B16F10 tumor models. We have observed a superior antitumor effect in the combined therapy group compared with either single treatment group alone.
In conclusion, our promising data derived from in vivo models combining Trk/CSF-1R blockade and immunotherapy supports the rationale for further testing of such combination in patients with cancer.
This abstract is also being presented as Poster A06.
Citation Format: Stephen Mok, Colm Duffy, Reginald Du, James P. Allison. Blocking Colony Stimulating Factor 1 Receptor (CSF-1R) and Tropomyosin Receptor Kinase (Trk) improves antitumor efficacy of immunotherapy. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology and Immunotherapy; 2016 Oct 20-23; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2017;5(3 Suppl):Abstract nr PR01.</jats:p
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