57 research outputs found
Chemoradiotherapy in locally advanced head and neck cancer patients: efficacy, toxicity and impact on quality of life
No full textContains fulltext :
199078.pdf (Publisher’s version ) (Open Access)Radboud University, 17 januari 2019Promotores : Graaf, W.T.A. van der, Kaanders, J.H.A.M., Herpen, C.M.L. va
Setting Africa’s rainfall straight: A warping approach to position and timing errors in rainfall estimates
No full textThere is an increasing number of rainfall products available over Africa and globally. Rainfall has considerable socio-economic impacts in sub-Saharan Africa, and the sparse gauge and radar networks make such estimates particularly valuable. They are used in many important applications such as drought/flood forecasting, water management or climate monitoring. The choice of which one to use has a significant influence on the output and performance of such applications. The large number of available rainfall products makes it difficult to select the “best” one for one’s need. Among the rainfall products, there is an increasing number of satellite-based estimates with ever finer resolution. They are particularly valuable in Africa where the gauge network is not dense enough to represent the high variability of the rainfall during the monsoon season. However, there are substantial differences between them. Rainfall events are moving systems which can be described by their positions and timings beside of their intensity. A position or timing error will also lead to mismatches in the rainfall occurrence or intensity. This is especially true for localized rainfall events such as the convective rainstorms occurring during the rainy season in sub-Saharan Africa. However, rainfall is mainly evaluated with respect to its intensity or occurrence, while position and timing errors are rarely studied.Mathematical PhysicsWater Resource
Treatment Techniques for Combined Sewer Overflows
No full textDuring storm events, the flow in a combined sewer system can exceed the capacity and, as a result, a combined sewer overflow (CSO) will occur. During a CSO raw wastewater is discharged to surface water. This wastewater is a mixture of raw sanitary wastewater, raw industrial wastewater and rainwater. The receiving water will get polluted by dissolved as well as undissolved pollutants. Therefore a CSO can cause damage to the ecological and biological state of the receiving water and besides it can cause public health risks. Until now the problem, with respect to CSOs in the Netherlands, is dominated by a quantitative approach. CSO flow rates and frequencies were in the past decades the main subject of research. These frequencies were translated into the Wet Verontreiniging Oppervlaktewater (1970). In the year 1998 the Ministry of Transport and Water Management came with a renewed policy, the fourth Memorandum on Water Management, dealing with groundwater, dehydration and water quality, for the protection and the recovery of nature. At the end of 2000 the European Water Framework Directive (WFD) came into force, which charges the European members of the EU to report obligatory. The aim of the WFD is to have an ecological and biological balance for all surface waters and groundwater in Europe effectively working in 2015. Measures are required to push back the pollution by defined dangerous substances. Measures with regard to the reduction of CSO frequencies alone is not enough to fulfil the legislation. When a CSO occurs an amount of pollutants will enter the surface water. CSO water needs to be treated to prevent pollution and odour annoyances to the surroundings. The goal of this research is to find a suitable treatment technique or a combination of treatment techniques. Primary and secondary techniques, adsorption and disinfection techniques are described. Primary techniques remove suspended solids and a fraction of the organic material, secondary techniques remove suspended solids and biological degradable material. Adsorption techniques are used to remove for example endocrine disrupting substances and disinfection techniques are used to minimize health risks for the population. In the Netherlands CSOs occur five to ten times a year per location. Therefore a treatment technique needs to be able to start up in a few minutes even after a long period without feedwater and should be able to handle wide and quick variations in flow without causing any inconveniences to the surroundings. Primary techniques like sieving, the Netting TrashTrapTM system and sedimentation basins and secondary techniques like membrane filtration, sand filtration and synthetic medium filtration are described. Adsoprtion techniques like activated carbon filtration and ion exchange and disinfection techniques like ozone dosage, chlorine dosage and UV treatment are described.Sanitary EngineeringWatermanagementCivil Engineering and Geoscience
Spin pump turnstile: Parametric pumping of a spin-polarized current through a nearly closed quantum dot
No full textComparison of Rainfall Products over Sub-Saharan Africa
No full textAn ever-increasing number of rainfall estimates is available. They are used in many important applications such as flood/drought monitoring, water management, or climate monitoring. Such data are especially valuable in sub-Saharan Africa, where rainfall has considerable socioeconomic impacts and the gauge and radar networks are sparse. The choice of a rainfall product can significantly influence the performance of such applications. This study reviews previous works, evaluating or comparing rainfall products over different parts of sub-Saharan Africa. Three types of rainfall products are considered: The gauge-only, the satellite-based, and the reanalysis ones. In addition to the global rainfall products, we included three regional ones specifically developed for Africa: The African Rainfall Climatology version 2 (ARC2), the Rainfall Estimate version 2 (RFE2), and the Tropical Applications ofMeteorology Using Satellite Data and Ground-Based Observations (TAMSAT) AfricanRainfall Climatology and Time Series (TARCAT). The gauge density, the orography, and the rainfall regime, which vary with the climate and the season, influence the performance of the rainfall products. This review does not focus on comparing results, as many other publications doing so are already available. Instead, we propose this review as a guide through the different rainfall products available over Africa, and the factors influencing their performances. With this review, the reader can make informed decisions about which products serve their specific purpose best.Water Resource
Case Report: Two Cases of Salivary Duct Carcinoma in Workers With a History of Chromate Exposure
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240726.pdf (Publisher’s version ) (Open Access
Case series of docetaxel, trastuzumab, and pertuzumab (DTP) as first line anti-HER2 therapy and ado-trastuzumab emtansine (T-DM1) as second line for recurrent or metastatic HER2-positive salivary duct carcinoma
No full textOBJECTIVE: Salivary duct carcinoma (SDC) overexpresses Human Epidermal growth factor Receptor 2 (HER2) in 29-46% of cases, favoring anti-HER2 therapy. Here, we present the results of patients with recurrent or metastatic HER2-positive SDC treated with docetaxel, trastuzumab, and pertuzumab (DTP) as first line anti-HER2 therapy and subsequently ado-trastuzumab emtansine (T-DM1) in second line. Furthermore, we searched for potential biomarkers. METHODS: Retrospective case series from a tertiary hospital. First line anti-HER2 treatment consisted of DTP, after progression T-DM1 was considered for patients with an adequate performance status. Objective response rate (ORR), progression-free survival (PFS) and overall survival (OS) were assessed and related to mRNA-based PI3K and MAPK signaling pathway activity scores. RESULTS: Thirteen SDC HER2 + patients received DTP. In twelve evaluable patients, one complete response (CR) and six partial responses (PR) were observed (ORR 58%), with a median PFS of 6.9 months (95%-CI 5.3-8.5). Seven patients received subsequent T-DM1 in second line, resulting in four PR (ORR 57%), with a median PFS of 4.4 months (95%-CI 0-18.8). Median OS after start of DTP was 42.0 months (95%-CI 13.8-70.1). Grade ≥ 3 toxicity on DTP was seen in 39% of patients, and 14% on T-DM1. Highest combined PI3K and MAPK signaling was seen in the patient with CR and lowest in the patient with progressive disease on DTP. CONCLUSION: In R/M HER2-positive SDC patients DTP followed by T-DM1 upon progression are promising treatments, leading to responses in the majority (58%) of the patients at an acceptable toxicity profile
68Ga-Prostate-Specific Membrane Antigen-Avid Malignant Pleural Effusion in a Patient With Metastatic Adenoid Cystic Carcinoma and Concordance With 18F-FDG PET/CT
No full textABSTRACT: Adenoid cystic carcinoma (ACC) is a rare cancer that arises from salivary glands and other secretory glands. Pulmonary metastases are frequently observed in ACC patients with metastatic disease. Previous research showed that ACC often shows high PSMA uptake on 68Ga-PSMA-11 PET/CT. Here, we present PET images from an ACC patient with pulmonal, pleural metastases, and malignant pleural effusion, with comparable tracer uptake on 68Ga-PSMA-11 PET and 18F-FDG PET
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