2,761 research outputs found
Liveable lelystad, creating a senior friendly urban environment
No full textArchitecture and The Built EnvironmentUrbanismDesign of the Urban Fabric
Letter from M.C. Morton, M.D., Director, Bluff Hospital, to Whom It May Concern, July 24, 1958
No full textThis letter, issued by Morton, M.C., M.D., Director, Bluff Hospital, Yokohama, Japan, explains that Tsugitada Kanamori has requested a certificate of ill health for the purpose of establishing dependency upon arrival to the Bluff Hospital in Yokohama. The letter describes his history of asthmatic attacks and the treatment for his cardiac asthma.This collection contains one box of documents belonging to Tsugitada Kanamori. Materials in this collection mostly pertain to Kanamori’s efforts regarding canceling his renunciation and reinstating his American citizenship
Letter from M.C. Morton, M.D., Director, Bluff Hospital, to Whom It May Concern, July 22, 1958
No full textThis letter, issued by Morton, M.C., M.D., Director, Bluff Hospital, Yokohama, Japan, explains that Tsugitada Kanamori has requested a certificate of ill health for the purpose of establishing dependency upon arrival to the Bluff Hospital in Yokohama. His illness had not been not identified.This collection contains one box of documents belonging to Tsugitada Kanamori. Materials in this collection mostly pertain to Kanamori’s efforts regarding canceling his renunciation and reinstating his American citizenship
2000 Sub-Librarians Meeting: Ace Atkins and M.C. Beaton
No full textThe Sub-Librarians planned and advertised a program with renowned science fiction and fantasy author Philip Jose Farmer. George Scheetz was instrumental in making that introduction. However, due to ill health, Farmer was unable to travel and had to cancel close to the program date.
However, on very short notice, Ace Atkins agreed to come to Chicago and speak to the group. Atkins had spoken to a very appreciative group of Sub-Librarians the previous year in New Orleans, and he gave another stellar performance in Chicago. He talked about his new book, Leaving\u27 Trunk Blues, which is another Nick Travers mystery, this one set in Chicago, from St. Martin\u27s Press.
St. Martin\u27s also stepped up and offered to have author M.C. Beaton join Ace as a speaker. M.C. Beaton is a pseudonym of Marion Chesney, who may be best known as the author of romance novels set during the English Regency. Her first detective story as M.C. Beaton came out for St. Martin\u27s in 1985. She has two series-one set in Scotland with Hamish Macbeth and one set in the Cotswolds with Agatha Raisin.
St. Martin\u27s generously provided copies of both authors\u27 books for signing after the program.
Marsha Pollak chaired the program, welcomed the audience, explained the change in speakers, called for toasts and introduced the authors
Drag it together with Groupie: making RDF data authoring easy and fun for anyone
No full textOne of the foremost challenges towards realizing a “Read-write Web of Data” [3] is making it possible for everyday computer users to easily find, manipulate, create, and publish data back to the Web so that it can be made available for others to use. However, many aspects of Linked Data make authoring and manipulation difficult for “normal” (ie non-coder) end-users. First, data can be high-dimensional, having arbitrary many properties per “instance”, and interlinked to arbitrary many other instances in a many different ways. Second, collections of Linked Data tend to be vastly more heterogeneous than in typical structured databases, where instances are kept in uniform collections (e.g., database tables). Third, while highly flexible, the problem of having all structures reduced as a graph is verbosity: even simple structures can appear complex. Finally, many of the concepts involved in linked data authoring - for example, terms used to define ontologies are highly abstract and foreign to regular citizen-users.To counter this complexity we have devised a drag-and-drop direct manipulation interface that makes authoring Linked Data easy, fun, and accessible to a wide audience. Groupie allows users to author data simply by dragging blobs representing entities into other entities to compose relationships, establishing one relational link at a time. Since the underlying representation is RDF, Groupie facilitates the inclusion of references to entities and properties defined elsewhere on the Web through integration with popular Linked Data indexing services. Finally, to make it easy for new users to build upon others’ work, Groupie provides a communal space where all data sets created by users can be shared, cloned and modified, allowing individual users to help each other model complex domains thereby leveraging collective intelligence
Een inventariserend veldonderzoek door middel van een proefsleuven
No full textIn opdracht van vastgoed ontwikkelingsbureau De Groene Groep uit Breda is in het onderzoeksgebied Beverwaardseweg-Oostdijk te Rotterdam door het Bureau Oudheidkundig Onderzoek van Gemeentewerken Rotterdam (BOOR) een inventariserend veldonderzoek uitgevoerd. Bij de beoogde nieuwbouw in het plangebied kunnen door toekomstige grondwerkzaamheden aanwezige archeologische waarden worden aangetast of vernietigd. Het voorliggende document betreft de rapportage van een inventariserend veldonderzoek. In het noordwestelijk deel van het onderzoeksgebied was al een vindplaats bekend. Er wordt aangenomen dat deze doorloopt in het resterende, niet
onderzochte deel van het onderzoeksgebied. Dit deel is door middel van proefsleuven geïnventariseerd en gekarteerd op aanwezigheid
van archeologische waarden die tevens gewaardeerd zijn. De vindplaats in het onderzoeksgebied heeft de BOOR vindplaatscode 13-89. Het onderzoeksgebied maakt deel uit van een groter plangebied, waarvan een deel in 2006 is geïnventariseerd. Het nu te onderzoeken deel was toen niet toegankelijk. In het al geïnventariseerde deel zijn bewoningssporen aangetroffen uit de Late Middeleeuwen die kunnen wijzen op de aanwezigheid van een huisplaats. De resultaten van dit onderzoek zijn weergegeven in BOORrapport 302 (Dorst 2006). Een korte samenvatting van de, voor de tweede fase van onderzoek relevante gegevens, is weergegeven in hoofdstuk 2. In hoofdstuk 3 zijn de onderzoekmethoden, de resultaten van het veldwerk en de waardering van de vindplaats beschreven. Ten slotte zijn in hoofdstuk 4 de conclusies van het onderzoek verwoord en is een aanbeveling geformuleerd ten aanzien van de omgang met de archeologische waarden in
het onderzoeksgebied
Neuromodulation shapes interneuron communication in the mouse striatum
No full textA proper understanding of cognition relies on detailed knowledge about the functional connectivity within and between brain areas. The striatum is generally regarded as the input structure to the basal ganglia, a group of subcortical nuclei that have been demonstrated to be involved in motor function and reward, amongst other functions. This becomes especially evident under pathological conditions such as Parkinson’s disease, when impaired motor function arises from reduced dopaminergic innervation of the striatum. These symptoms can be partially explained by the divergent effect dopamine exerts on the excitability of striatal projection neurons. However, less is known about its modulatory effects on striatal interneurons and the physiological outcomes of altered interneuron communication. Through a combination of ex vivo patch-clamp electrophysiology, in vivo extracellular recordings and transgenic labelling of specific interneuron populations, we probed interneuron communication in the striatum under normal and dopamine-depleted conditions. Furthermore, through opto- and chemogenetic manipulation we investigated how various neurotransmitters alter neuronal communication and how this affects the activity of the striatal projection neurons.In study 1 we investigate the differential inhibition of striatal projection neurons by subpopulations of parvalbumin-expressing interneurons. Subpopulations of these interneurons are characterized by their selective co-expression of the calcium-binding protein secretagogin. Interneurons co-expressing secretagogin are heterogeneously distributed and preferentially inhibit projection neurons of the direct pathway. Conversely, parvalbumin-expressing interneurons negative for secretagogin are more homogeneously distributed throughout the striatum and are biased towards indirect-pathway projection neurons. The ability of dopamine to elicit spiking was investigated computationally in study 2. Dopamine induced depolarizations in direct-pathway projection neurons, in particular through down-regulating the Kv4.2 potassium channel. However, these effects alone are insufficient to explain the fast firing onset following dopamine release observed experimentally. Further modulation of striatal projection neurons may be enacted through co-release of other neurotransmitters. In study 3 we demonstrate glutamate co-release from midbrain dopamine neurons onto D1-receptor expressing projection neurons in the Nucleus Accumbens. A conditional Vglut2-knock-out mouse model was developed to target mature dopamine neurons, which isolates these effects from compensatory mechanisms during development. We thus demonstrated that Vglut2-mediated glutamate transmission from mature dopamine neurons modulates baseline AMPA/NMDA ratios. This highlights the role of glutamate co-release in synaptic plasticity, especially in relation to drug addiction. Midbrain dopamine neurons play a further role in modulating interneuron communication in the dorsal striatum. In study 4 we demonstrate that dopamine, acting on D2 receptors, inhibits polysynaptic communication between cholinergic interneurons in the dorsal striatum. This polysynaptic inhibition between cholinergic interneurons is partially mediated by gabaergic interneurons co-expressing the enzyme tyrosine hydroxylase. We also report gabaergic innervation on striatal cholinergic interneurons from dopaminergic and gabaergic projection neurons in the ventral tegmental area and the substantia nigra pars compacta, potentially providing additional connectivity and methods of control between the striatal dopamine and acetylcholine systems. In study 5 we subsequently modelled many of these interactions in a detailed striatal model which receives realistic input from the cortex, thalamus and dopamine system. By modelling interactions between striatal interneurons and projection neurons we are able to provide a substrate for detailed investigations into striatal dynamics. Through multi-compartmental neuron models which closely match their biological counterparts we are able to investigate network effects on an unprecedented level. We have made this model publically available so it may be freely augmented and adjusted where necessary to study different aspects of striatal function.By identifying selective pathways of innervation within and into the striatal network, we are now better able to understand how disrupting these pathways affects striatal function. In particular the role of dopamine and how it modulates striatal output has been revised in these studies. This has important ramifications for how we can interpret the physiological changes observed in altered dopaminergic states, such as those found in patients with Parkinson’s disease. Going forward, our results highlight the necessity for a detailed map of the striatal microcircuit in general and particularly how the microcircuit is affected by the neuromodulators that underlie striatal function on both shorter and longer time-scales.List of scientific papersI. Garas, F.N., Shah, R.S., Kormann, E., Doig, N.M., Vinciati, F., Nakamura, K.C., Dorst, M.C., Smith, Y., Magill, P.J. and Sharott, A. 2016. Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons. Elife. 5, p.e16088. https://doi.org/10.7554/eLife.16088 II. Lindroos, R., Dorst, M.C., Du, K., Filipović, M., Keller, D., Ketzef, M., Kozlov, A.K., Kumar, A., Lindahl, M., Nair, A.G., Pérez-Fernández, J., Grillner, S., Silberberg, G., Kotaleski, J.H. 2018. Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales—Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4.2. Frontiers in neural circuits. 12, p.3. https://doi.org/10.3389/fncir.2018.00003 III. Papathanou, M., Creed, M., Dorst, M.C., Bimpisidis, Z., Dumas, S., Pettersson, H., Bellone, C., Silberberg, G., Lüscher, C. and Wallén-Mackenzie, Å. 2018. Targeting VGLUT2 in mature dopamine neurons decreases mesoaccumbal glutamatergic transmission and identifies a role for glutamate co-release in synaptic plasticity by increasing baseline AMPA/NMDA ratio. Frontiers in neural circuits. 12, p.64. https://doi.org/10.3389/fncir.2018.00064 IV. Dorst, M.C., Tokarska, A., Zhou, M., Lee, K., Stagkourakis, S., Broberger, C., Masmanidis, S. and Silberberg, G. 2020. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. [Submitted]V. Hjorth, J.J., Kozlov, A., Carannante, I., Nylén, J.F., Lindroos, R., Johansson, Y., Tokarska, A., Dorst, M.C., Suryanarayana, S.M., Silberberg, G., Kotaleski, J.H., and Grillner, S. 2020. The microcircuits of striatum in silico. Proceedings of the National Academy of Sciences. 117(17), pp.9554-9565. https://doi.org/10.1073/pnas.2000671117 </p
A Validated Framework for Measuring Interface Support for Interactive Information Seeking
No full textIn this paper we present the validation of an evaluation framework that models the support provided by search systems for different types of user and their expected types of seeking behavior. Factors determining the types of users include previous knowledge and goals. After an overview is presented, the framework is validated in two ways. First, the novel integration of the two existing information-seeking models used in the framework is validated by the correlation of multiple expert and novice analysis. Second, the framework is validated against the results produced by two separated user studies. Further, the refinements made by the first validation technique are shown to increase the accuracy of the framework through the second technique. The successful validation process has shown that the framework can identify both strong and weak areas of search interface design in only a few hours. The results produced can be used to either revise and strengthen designs or inform the structure of a user study
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
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