169,818 research outputs found
C. Louise Thijssen-Schoute, Nederlands Cartesianisme
No full textDopp Joseph. C. Louise Thijssen-Schoute, Nederlands Cartesianisme. In: Revue Philosophique de Louvain. Troisième série, tome 53, n°37, 1955. pp. 101-102
C. Louise Thijssen-Schoute, Nederlands Cartesianisme
No full textDopp Joseph. C. Louise Thijssen-Schoute, Nederlands Cartesianisme. In: Revue Philosophique de Louvain. Troisième série, tome 53, n°37, 1955. pp. 101-102
David Hume, New Letters of David Hume, edited by Raymond Klibansky and Ernest C. Mossner
No full textDopp Joseph. David Hume, New Letters of David Hume, edited by Raymond Klibansky and Ernest C. Mossner. In: Revue Philosophique de Louvain. Troisième série, tome 53, n°37, 1955. pp. 102-103
Chauncey Wright, The Philosophical Writings of C. W. Representative selection, edited with an Introduction by Edward E. Madden
No full textDopp Joseph. Chauncey Wright, The Philosophical Writings of C. W. Representative selection, edited with an Introduction by Edward E. Madden. In: Revue Philosophique de Louvain. Troisième série, tome 57, n°53, 1959. p. 117
Chauncey Wright, The Philosophical Writings of C. W. Representative selection, edited with an Introduction by Edward E. Madden
No full textDopp Joseph. Chauncey Wright, The Philosophical Writings of C. W. Representative selection, edited with an Introduction by Edward E. Madden. In: Revue Philosophique de Louvain. Troisième série, tome 57, n°53, 1959. p. 117
Form and Strategy in Science. Studies dedicated to Joseph Henry Woodger on the occasion of his seventieth birthday, edited by John R. Gregg and F. T. C. Harris
No full textDopp Joseph. Form and Strategy in Science. Studies dedicated to Joseph Henry Woodger on the occasion of his seventieth birthday, edited by John R. Gregg and F. T. C. Harris. In: Revue Philosophique de Louvain. Troisième série, tome 63, n°79, 1965. pp. 483-484
Form and Strategy in Science. Studies dedicated to Joseph Henry Woodger on the occasion of his seventieth birthday, edited by John R. Gregg and F. T. C. Harris
No full textDopp Joseph. Form and Strategy in Science. Studies dedicated to Joseph Henry Woodger on the occasion of his seventieth birthday, edited by John R. Gregg and F. T. C. Harris. In: Revue Philosophique de Louvain. Troisième série, tome 63, n°79, 1965. pp. 483-484
PET Imaging of Fatty Acid Amide Hydrolase with [<sup>18</sup>F]DOPP in Nonhuman Primates
No full textFatty
acid amide hydrolase (FAAH) regulates endocannabinoid signaling.
[<sup>11</sup>C]CURB, an irreversibly binding FAAH inhibitor, has
been developed for clinical research imaging with PET. However, no
fluorine-18 labeled radiotracer for FAAH has yet advanced to human
studies. [<sup>18</sup>F]DOPP ([<sup>18</sup>F]3-(4,5-dihydrooxazol-2-yl)phenyl
(5-fluoropentyl)carbamate) has been identified as a promising <sup>18</sup>F-labeled analogue based on rodent studies. The goal of this
work is to evaluate [<sup>18</sup>F]DOPP in nonhuman primates to support
its clinical translation. High specific activity [<sup>18</sup>F]DOPP
(5–6 Ci·μmol<sup>–1</sup>) was administered
intravenously (iv) to three baboons (2M/1F, 3–4 years old).
The distribution and pharmacokinetics were quantified following a
2 h dynamic imaging session using a simultaneous PET/MR scanner. Pretreatment
with the FAAH-selective inhibitor, URB597, was carried out at 200
or 300 μg/kg iv, 10 min prior to [<sup>18</sup>F]DOPP administration.
Rapid arterial blood sampling for the first 3 min was followed by
interval sampling with metabolite analysis to provide a parent radiotracer
plasma input function that indicated ∼95% baseline metabolism
at 60 min and a reduced rate of metabolism after pretreatment with
URB597. Regional distribution data were analyzed with 1-, 2-, and
3-tissue compartment models (TCMs), with and without irreversible
trapping since [<sup>18</sup>F]DOPP covalently links to the active
site of FAAH. Consistent with previous findings for [<sup>11</sup>C]CURB, the 2TCM with irreversible binding was found to provide the
best fit for modeling the data in all regions. The composite parameter <i>λk</i><sub>3</sub> was therefore used to evaluate whole
brain (WB) and regional binding of [<sup>18</sup>F]DOPP. Pretreatment
studies showed inhibition of <i>λk</i><sub>3</sub> across all brain regions (WB baseline: 0.112 mL/cm<sup>3</sup>/min;
300 μg/kg URB597: 0.058 mL/cm<sup>3</sup>/min), suggesting that
[<sup>18</sup>F]DOPP binding is specific for FAAH, consistent with
previous rodent data
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
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