133 research outputs found

    Michael A. Messner et Donald F. Sabo (eds.), Sport, Men, and the Gender Order : Critical Feminist Perspectives, Champaign (Illinois), Human Kinetics Books, 1991

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    Wacquant Loïc J. D. Michael A. Messner et Donald F. Sabo (eds.), Sport, Men, and the Gender Order : Critical Feminist Perspectives, Champaign (Illinois), Human Kinetics Books, 1991. In: L'Homme et la société, N. 105-106, 1992. Vers quel désordre mondial ? pp. 182-183

    Sex, Violence & Power in Sports : Rethinking Masculinity

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    By Michael A. Messner & Donald Sabo (former College at Brockport faculty member). The authors, both academics and former athletes, examine the culture of male sports and its relation to concepts of masculinity. The basic premise is that male-dominated sports foster homophobia and the denigration of women. This is not new news for anyone who has spent time in an adolescent male locker room. What is news, however, is the authors\u27 linking of locker-room mentality with data indicating that on some college campuses a third of all reported rapes involve male athletes, who represent less than a third of all males on campus. The authors hold that this sort of data--numerous studies are cited revealing the same trend--exposes the inherent flaws in traditional male sports culture. Sports, they say, breed intolerant males more prone to violence, domestic abuse, and homophobia and less likely to sustain a long-term relationship with a woman. This premise may or may not be entirely valid; further research is clearly needed. Still, the authors\u27 findings--especially in context of the O. J. Simpson case--raise points of serious discussion regarding athletes and violence. --Booklisthttps://digitalcommons.brockport.edu/bookshelf/1227/thumbnail.jp

    The promises and pitfalls of sex integration in sport and physical culture

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    Scholars working in the academic field of sport studies have long debated the relationship between modern sport and gender (e.g. Hargreaves and Anderson, 2014; Hargreaves, 1994; Lenskyj, 1986; Messner, 2002). Within this body of work, modern sport forms – along with a great diversity of related activities, including dance, fitness training, physical education, etc. – have consistently been shown to carry meanings relative to the structures of gender prevailing in the wider social settings within which they take place, with patterns of participation and consumption clearly mapping onto gendered ideals. However, rather than simply mirroring such social norms, research suggests that many sporting practices were invented or have been purposefully developed in order to train young men and women in socially-approved gender behaviors to begin with (Cahn 1994; Hargreaves 1994; Theberge, 2000). Thus, much of contemporary physical culture finds its roots in the process which scholars describe as the ‘social construction of gender’; in other words, doing sports and other activities in gender-differentiated ways has long been a means of producing and maintaining difference in the lives of men and women, girls and boys.Peer reviewedAccepted author manuscript of a peer reviewed article accepted for publication by Taylor & Francis in Sport in Society: Cultures, Commerce, Media, Politics online on 28/12/2015

    College of Pharmacy, University of Utah, Class of 1985. "Senior Banquet" Invitation

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    College of Pharmacy, University of Utah, Class of 1985. "33rd Annual Senior Panorama Banquet" Invitation. Tuesday, May 28, 1985, 6:30 pm. Dinner. Introductions: Dr. Harold H. Wolf, Dean. Preceptor of the Year Award: Mr. Evan Love, Syntex Lab, Inc. Address: "The Pharmacy Organizational World," Dr. Arthur G. Lipman, Chairman, Department of Pharmacy Practice, University of Utah College of Pharmacy. Adjournment. Guest Sponsors: AMFAC Drug Supply Co., Bergen Brunswig Drug Co., McKesson & Robbins Drug Co. Pharmacy Graduates 1985: Abdala, Mike H.; Aminian, Firoozeh; Balk, Mark A.; Bradshaw, Daniel A.; Burnham, John F.; Carlstrom, Waldemar; Cee, Rick J.; Christensen, Betty R.; Cork-Asher, Cynthia; Craven, Kathryn H.; Doan, Lan-Anh T.; Fannin, Kathleen M.; Fung, Man-Cheong; Harte, Claire J.; Heiner, Christina R.; Holt, Clifford E.; Johnson, James E.; Johnson, Mark D.; Killpack, Roger E.; Kottke, Karin L.; Lew, Evelyn; Messner, Adele C.; Motoyama, Yoshiko; Richardson, Rory M.; Robbins, Glenn B.; Sadiq, Francis J.; Schotik, Debora A.; Scozzare, Monica L.; Sower, Brett; Strzyzewski, Claudia; Thai, Nanci; Tracy, Donald R.; Tsai, Wen H.; Turner, Mona Lisa K.; Webb, William D.; Whittaker, Suzanne E.; Wintch, David A.; Wong, Joseph C. T.; Zargarzadeh, Amir H

    Class of 1901

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    Class composite photograph for Chicago-Kent College of Law class of 1901. Students and faculty pictured: Faculty Elmer E. Barrett Thomas E.D. Bradley Edmund Whitney Burke Orrin N. Carter Frank Hall Childs Marshall D. Ewell William Elmore Foster John Gibbons M. Henry Guerin Edward C. Higgins Thomas A. Moran Charles G. Neely Grant Newell William J. Pringle Henry M. Shepard Simeon P. Shope J.H. Van Horn Students Charles F. Ahern Carl Barnard Edward H. Barron John A. Bauer Pierre G. Beach Sidney E. Beach Maurice Berkson Joseph B. Beutel Louis K. Boysen George W. Bright Charles R. Brown James C. Brown Edward P. Castle Ainsworth Clark Charles E. Congleton Edwin E. Cox Thomas F. Delaney Fred L. Divine David P. Dullard Theodore F. Ehler Morley F. Fox Charles E. Gaylord Robert Gregg Mark E. Guerin Elmer E. Hills Harry B. Houghton Wendell Huston John Jacobson G. Mostyn Jones S. Minot Jones W.J. Kirk George Kolb Joseph S. LaBuy Frank J. Lammers Richard J. Lavery Daniel W. Lee Frank S. Lewis W.R. Litzenberg Lewis L. Losey, Jr. Donald H. Mann Duncan B. McEarchern/McEachern Frederick Merce Max Messner D. Joseph Normoyle Charles J. Novak Albert O. Olson Richard W. Owen Charles A. Phelps Turner Pierce Bertram E. Pinkerton John A. Reilly Frak S. Righeimer John G. Romer Andrew Rost, Jr. John D. Ryan Louis J. Schmitt Fayette F. Soule Charles A. Theis Walter True Karl H. Van Hovenberg/Havenburg Noble S. Ward William C. Weinert James S. Wight Ira T. Wighthttps://scholarship.kentlaw.iit.edu/composites/1005/thumbnail.jp

    Laser-fabricated cell patterning stencil for single cell analysis

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    abstract: Precise spatial positioning and isolation of mammalian cells is a critical component of many single cell experimental methods and biological engineering applications. Although a variety of cell patterning methods have been demonstrated, many of these methods subject cells to high stress environments, discriminate against certain phenotypes, or are a challenge to implement. Here, we demonstrate a rapid, simple, indiscriminate, and minimally perturbing cell patterning method using a laser fabricated polymer stencil. The stencil fabrication process requires no stencil-substrate alignment, and is readily adaptable to various substrate geometries and experiments.The electronic version of this article is the complete one and can be found online at: https://bmcbiotechnol.biomedcentral.com/articles/10.1186/s12896-017-0408-

    Framework for Context-Aware Information Processing for Design Review in a Virtual Environment

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    Design review is a process of reviewing construction design documents to ensure that they reflect the owner's design intent, and are accurate in describing the owner's desired building or facility. Information generation becomes more intensive as the design stage progresses. The use of valuable information during design review stage can lead to a more comprehensive and high quality design, and a building or facility that is constructible, and within the intended budget. However, in current design practices, valuable design review information is scattered, ineffectively placed, and is not used efficiently. The design review process will be more efficient if this valuable information is integrated and centralized. The author developed a framework to improve the design review process by incorporating a centralized repository of design review information and 3D CAD model, in an interactive Virtual Environment (VE). To develop the framework, the author used Action Research style where he identified and confirmed the design review problem area, promoted the potential solutions to the problem, and developed a prototype. In gathering and analyzing the data for the research, the author used the synthesis of three methods. They include review of literature, a case study (interviews with industry personnel and content analysis of design review documents), and dissemination of the author's progressive findings in conferences, conference proceedings and journal publications. From his findings, the author developed the framework to improve the design review process by using information filtering based on context-aware concept, coupled with the benefits of a VE. The required design review information in the form of textual, numerical and geometric information is processed (queried, retrieved and stored). The author defined four contexts for information filtering: discipline-centric, task-centric, object-centric, and location-centric. IF-THEN rules are used to trigger the processing of the required design review information and present it to the design reviewer in a VE. A low cost 3D Game Engine is used as the enabling development tool to develop a work-in-progress (WIP) prototype design review application in a VE.Ph. D

    Louis V. Messner oral history interview: The Office of Budget and Fiscal Affairs, Oral History Project on the Origins of The California State System, Phase II, 1995

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    Oral history interview with a primary focus on the origins of the California State University System and the 1960 master plan for California higher education.Transcripts and cassette tapes of oral history interviews with various individuals involved in the formation of the California State University system.CALIFORNIA STATE UNIVERSITY ARCHIVES Oral History Project on the Origins of the CSU System, Phase II LOUIS V. MESSNER THE OFFICE OF BUDGET AND FISCAL AFFAIRS, 1967-1990 Interview Conducted by Lawrence B. de Graaf February 8,1995 Processed in cooperation with CSU Fullerton Oral History Program 1995 COPYRIGHT This is a transcription of an interview conducted for the California State University Archives under a grant from the Office of the Chancellor, CSU. Scholars are welcome to utilize short excerpts from any of the transcriptions without obtaining permission as long as proper credit is given to the interviewee, interviewer, and the institution sponsoring the project. All uses of this manuscript are covered by a legal agreement between the CSU Archives and the interviewee. Therefore, scholars must obtain permission from California State University Archives before making more extensive use of the transcription and related materials. None of these materials may be duplicated or reproduced by any party except the California State University Archives. However, because it is the goal of this project to preserve and make accessible significant documentation relevant to the history of the State Colleges, copies of any unrestricted transcriptions may be obtained at cost by writing to the CSU Systemwide Archivist at California State University, Dominguez Hills, Carson, California 90747. Copyright c 1996 by the Board of Trustees of The California State University PREFACE The purpose of Phase II of the California State University Oral History Project is to record and make available to researchers using the California State University Archives the reminiscences of individuals who participated in development of the CSU system. Creation of the California State Colleges in 1961 united fifteen formerly independent colleges into a single identifiable system, with its own Board of Trustees and a Chancellor to serve as chief executive officer. Using a formula that stressed systemwide planning in the allocation of resources and programs, the California State Colleges sought to offer Californians quality higher education at reasonable cost. Key to the success of the State Colleges was the decision to implement a Master Plan adopted in 1960 that divided higher education into three distinctly separate segments. The State Colleges were mandated to emphasize undergraduate and master's level programs, while the University of California campuses were to emphasize graduate education, and the Community Colleges vocational training and college preparation. The present California State University, starting from a base of fifteen campuses and 95,000 students in 1961, has grown to where it provides a wide variety of innovative programs to more than 320,000 students on 22 campuses. It is the largest system of higher education in the United States and is known as one of the strongest institutions of higher education in the country. In September 1979, the Board of Trustees created the California State University Historical Archives, to be housed on the Dominguez Hills campus. Since its establishment, the Archives, as a systemwide project, has been supported by the Chancellor's Office through the funding of a professional archivist. The Archives currently houses a collection of materials from a variety of sources. These include the Chancellor's Office, the CSU Academic Senate, and private individuals such as former Chancellor Glenn Dumke and former Trustee Paul Spencer. Consequently, the Archives holds some personal papers as well as official systemwide documents. As part of its collection policy, the Archives also has a responsibility to gather individual recollections and oral histories of the system. Phase I of the CSU Oral History Project, conducted from 1986 to 1989, and funded by the Chancellor's Office, covered the formation and early years of CSU through 32 interviews with participants within and without the system. These interviews, housed at the CSU Archives, have proven useful to research into higher education in the 1950s and ’60s. A major quality is their standardized format, developed at the Oral History Program at CSU Fullerton. Phase II is an ongoing oral history project that is decentralized but administered by the CSU Archives. Its intent is to assure that the reminiscences of retiring chancellors, principal staff members, Academic Senate chairs, Student Association presidents, trustees, and local campus presidents be recorded as closely as possible to their retirement date and that this be done routinely as a regularized process. Phase II also seeks information on the growth of the CSU during two mid-decades, 1964-85. The project has three long-range purposes. First, it will help to increase interest in the history and accomplishments of the California State University. Next, it will be a tool in aiding the acquisition of additional materials concerning the System now in private hands. Finally, it will create needed documentation for understanding the System's historical role in state and national education; many issues it has confronted have become matters of national concern, such as meeting the needs of a multicultural student body and finding adequate resources in a time of scarcity. Oral history can provide background information on these developments that is not available in bulletins, brochures, and minutes. Funding for the project is provided by the Office of the Chancellor, Dr. Barry Munitz. We thank the interviewee for generously giving of his time. We also acknowledge the pioneering work of the CSU Fullerton Oral History Program in providing a model. Transcribing was performed by Garnette Long, who in the process contributed many wise editorial suggestions. Lawrence B. de Graaf Tim Gregory Judson A. Grenier Acting CSU Archivist Project Co-directors MEMBERS, CSU ARCHIVES ADVISORY COMMITTEE Betty J. Blackman William D. Campbell Lawrence B. de Graaf Robert C. Detweiler David E. Leveille Gloria Lothrop Barry Munitz Lyn Olsson John Pfau Teena Stem Helene Whitson Samuel Wiley Donald R. Gerth Harold Goldwhite Tim Gregory Judson A. Grenier IV CALIFORNIA STATE UNIVERSITY ARCHIVES ORAL HISTORY PROJECT ON THE ORIGINS OF THE CSU SYSTEM This interview of Louis V. Messner, was done at his home in San Pedro, California, on Tuesday, February 8,1995, as part of phase two of the ongoing CSU Oral History Project. The interviewer is Lawrence B. de Graaf, Professor of History at California State University, Fullerton. LM: I came to the California State Colleges in 1967. Vice Chancellor [Harry] Brakebill actually interviewed me, and Glenn Dumke was the chancellor at the time. Mr. Brakebill had me fly down to L.A. to interview with Dumke. Actually I spent about three minutes with Dumke. He basically said whatever Brakebill wanted he would support, and it was a very simple hiring. Actually, at that time in the system there was no searching or competition or tests or structure, in terms of the recruiting process. I know with the State it was very rigid. You had to take tests and get on lists and compete both orally and on written tests. I’d been accustomed to that, but this was sort of like I was handpicked, and it worked out in terms of my career. I think I was fortunate at the time, being picked. LD: Excuse me, let me just make sure everything is coming across. Now let me introduce this thing. This is an interview with Louis V. Messner for the CSU Archives Project. It's being done on Tuesday, February 8, 1995, in Mr. Messner's home in San Pedro. All right, Mr. Messner, sorry to interrupt you, but let's go back to your pre-Department of Finance days. Where were you born? LM: Actually, I was born in Winnipeg, Manitoba. I was a Canadian citizen; my family came down during World War II years. My father came to work in the shipyards in Richmond, California, and so we all came down, a rather big family, eight children, and my parents. LD: You were just a child then? LM: I was about thirteen. The whole family just picked up and moved. Father worked in the shipyards; ultimately, my father and mother became naturalized, and I became naturalized under them while growing up. I went to a minor seminary for five years with my older brother to become a priest. Both of us dropped out. One of my MESSNER 2 younger brothers also went to the seminary and is a priest today, so I had sort of a religious seminarian training, which I thought was pretty good in terms of educational background that has served me well. After the seminary I went to the University of California and majored in accounting. But that was during the Korean War and they were drafting people, and I was going to be drafted, so I went into the Air Force and became an Air Force cadet in navigator training and served my time as a navigation instructor during the Korean War. And then I got out. I still hadn't completed my college, so I debated going to UC Berkeley or San Jose State. Because I could get into married student housing easier, I went to San Jose State and obtained my degree. LD: What year was that? LM: Oh, that was 1957-58. I interviewed with a number of companies. I had excellent grades at that point. I was more mature, you know, going back after your service. I had accepted a job with Del Monte Packing Company. But I had also taken an interview with Sacramento, the State Department of Finance, for less money. I wanted the job in Sacramento, I wanted to work for the Department of Finance. So I called them and I said, "I've got to know within twenty-four hours.” They sent me a telegram two hours later offering me the job. So then I had to call back and tell Del Monte that I didn't want to take their job. They couldn't believe it. But I saw the possibility for advancement with the Department of Finance much better than with Del Monte. So I went with the Department of Finance, and I've never regretted it. It's been very good. At the time when I was working on the colleges, and the California State Colleges were going through a tremendous transformation, the starting of a system not under the Department of Education. They started off with [Buell] Gallagher as their chancellor. He just didn't have rapport with the legislative and executive branches of government on the campuses. I mean, he had done a lot of things, such as moving the office out of Sacramento in the dead of night, that alienated him. So then they brought in Dr. Dumke, who had been the president of San Francisco State and one of the architects of the Master Plan for Higher Education, and made him the chancellor. Of course, he was an outstanding academician. And Dumke brought Brakebill from San Francisco, where he was his vice president, and made him the Vice Chancellor for Business Affairs. The other problem with the MESSNER 3 Chancellor's Office is they had very little rapport with the campuses, very bad alienation: central office versus decentralized institutions. LD: You could see this from the Department of Finance? LM: Oh yes, it was evident. In the Department of Finance I developed a tremendous rapport with the campuses, as well as the Chancellor's Office, and Brakebill saw that and thought that that would be good. He also saw that I had some good background, in terms of institutional budgeting, in terms of formulas and dealing with ten institutions in Corrections, and eight institutions in Youth Authority, and trying to be equitable with those institutions on the allocation of money and budget for them. He liked that, so that's basically why he picked me. And so I came down to Los Angeles. I was more of a technician to start with, and I basically designed the system of budgeting. First of all it was a manual system. Then I hired people that were computer-oriented, and we computerized the formulas. We developed what is called the Orange Book, and that became sort of the bible for budgeting for, I'd say, twenty to twenty-five years in the California State University. Initially I was not involved with the decision or policy hierarchy of the Chancellor's Office. I was hired as the Chief of Budget Planning, and then there was, you know, assistant vice chancellor, vice chancellors, and then the chancellor. I didn't necessarily relate to the trustees initially. Brakebill did that. I related to the colleges, and I developed, I believe, an excellent rapport and credibility with the campuses. Because of the dissatisfaction with Chancellor Gallagher, Dumke and Brakebill came into the Chancellor's Office to change the attitude of the central office towards the campuses. Brakebill had been on a campus, and he brought several people in from the campuses. Of course, I looked at Brakebill, you know, as an idol, really. He was a gentleman all the way, and very, very intelligent and knowledgeable. And so basically as I developed the budget the need for funds grew over the years and the role of the budget became a central issue. After a number of years, they made me an assistant vice chancellor. LD: What year was that? LM: It was in 1979 that I became Assistant Vice Chancellor, and then I became Acting Vice Chancellor of Business Affairs in 1991. In 1992 they made me Vice Chancellor of Business Affairs, and then I retired when I contracted lung cancer. I'll give you that as sort of a background. The system that we developed in budgeting was MESSNER 4 outstanding nationwide. Many other campuses requested it. Of course, the Master Plan for Higher Education in California, with Dumke as one of the architects, theoretically became a master plan for many other states, as you're well aware. They picked up what California had done and implemented it in Michigan, Illinois, Florida and, you know, just literally a number of states, and it became the master plan for the country almost. Then towards the end of my tenure, when we started getting into major funding problems, the formulas didn't work. Because irrespective of the formula, they didn't have the money, and so the formulas became meaningless. Initially the formulas provided the funds necessary to do the job. But then when they didn't have the money, then they started moving things all around, and eventually the formulas became meaningless. So actually the Orange Book went out of existence and was replaced with a straight allocation accompanied by greater flexibility. The California State Colleges, when they started off, had always been treated or considered as another state agency— you know, a controller's office or the state libraries or whatnot— and so the legislature always treated the system as if we were another state agency, and they refused to give us the flexibility to manage our own funds and control expenditures as they did with the University of California. Of course, the University of California had a constitutional exemption, and so they had a rather broad authority and flexibility and we always had to go back to the legislature to get little tiny pieces of authority to bring to our board of trustees. And so, during my career, and Brakebill's too, we were constantly trying to get our independent authority over not only academic issues but also for the budget itself. We were successful, but really complete flexibility came at the end of my career, but at that point they didn't have the money. Present Chancellor [Barry] Munitz says, "Well, we know you don't have the money, just give us what you can. Let us spend it the way we want." And with that a number of significant changes occurred. So right now there's a tremendous evolution that's going on in terms of basics and basis of budgeting. It's essentially taking last year's appropriation and adding 1 percent or 2 percent or minus 3. But they've lost any semblance on the basis of all detail, and they're struggling to find an equitable rationale for future projections and needs. Because they threw out the Orange Book completely, they had nothing. They had to go through a change. I don't fault that at all. But the Orange Book was based on enrollment drives and workload MESSNER 5 drives,1 and it was developed to be equitable to all the campuses. Through regression analysis, we set up the formulas and standards, and we thought it treated everybody the same. Of course, the smaller campuses thought the larger campuses fared the best; the larger campuses thought vice versa. I think overall it was equitable, but to show how equitable it was, even people in my own budgeting office were unconvinced who fared the best, large campuses or small campuses. So the Orange Book formulas had always been a bone of contention over its bias, even though no one could prove it to be unfair. It served the system well through a period of growing enrollment. Of course, the enrollment topped off and then literally dropped with the cutbacks and lower fee revenue. So now they're struggling to find a way to budget. They haven't come up with a solution yet. And they'll probably come up with some modification or alternative to the Orange Book. They won't come up with another Orange Book because it developed such an animosity between staff and administration due to the way people used it. For instance, a dean of students saw that he was entitled to get one administrative assistant and one clerical position, and for every 200 FTE students he would get one counselor, etcetera. So he could read the Orange Book and he'd go to the president and say, "This is what I'm entitled to," and the president would say, "Well, we don't have enough money," and neither would end up satisfied. So it started setting up internal problems on the campuses. A major executive decision was made to just get rid of it completely. But to this date they haven't been able to find an acceptable substitute. LD: This is a very good introductory overview. Now I'd like to now pull out some specifics and have you elaborate on them. First let's go back briefly to your work in the Department of Finance. You said earlier before we had the tape recorder on that you came there about 1958, and at first you worked on various institutional projects? LM: Initially they assign analysts to a number of agencies, and I was first assigned to the Departments of Agriculture, Highway Patrol, Motor Vehicles, Justice, and you handle their budgets. You worked with those departments, assist them in developing their budget, presentation to the legislature, etcetera. And then they'd move you around every couple of years so that you didn't become too friendly and become an lAny three or four pages from the Orange Book would illustrate the staffing of a given office. MESSNER 6 advocate for those agencies. So I moved around. My first move was actually to a Methods and Procedures unit for the whole Budget Division developing methods and procedures for the state budget. I worked under an individual named Dale Hanner there. That was my second assignment, and he was, in my mind, an outstanding individual, in terms of his knowledge and ability, and he taught me quite a bit. Subsequently, in 1970, when Brakebill was promoted to Executive Vice Chancellor, he started searching for a vice chancellor. I recommended Hanner, and he got it. Of course he had moved around. He had been the Chief of Audits and had held other positions. So Hanner became the Vice Chancellor of Business Affairs, to the discernment of a number of people internally, because they thought that they were entitled to move up to it, and he was an outsider. I think he was an outstanding vice chancellor. He stayed there for twenty-five years, and then he retired, and I sort of followed in his footsteps. So, in a way, I had a link with him that went back over my entire career. LD: That's interesting. LM: After my stint with him, I went on to Corrections and Youth Authority. I spent eight years in the Department of Finance, and I probably spent five of those eight years with Corrections and Youth Authority. That was a time when they were building a number of new institutions and staffing these new prisons— of course, they still are today. It was similar to the California State University because we were building and staffing new institutions, so there was a correlation there and I just happened to fit in. I always maintain that your career sometimes was based upon a lot of luck, being at the right place at the right time. I happened to be there, I thought, with Mr. Brakebill, and it just worked like magic. LD: Now, when you did these stints at the Department of Finance, were you essentially helping agencies develop what would become the Governor's Budget? LM: Yes. Basically agencies would submit their budget, and we would analyze their budget, make recommendations to the Department of Finance, meet with the director of the department and iron out all the differences, and then come to some conclusion on their budget. Then that would become a component of the Governor's Budget. The Governor's Budget would then be introduced to the legislature. Legislative analysts would attack it, we'd go to budget hearings and resolve differences. Ultimately the legislature would pass the budget MESSNER 7 and it came back to the governor for approval. It always happens that you're working on three different budgets all the time: the current, past, and future budget. And you also worked with the agency administration on the day-to-day needs, transfers, etcetera. At one time, the Department of Finance used to approve all the documents, all the personnel transactions, equipment purchases, and a numb

    Neoplastic transformation of rat liver epithelial cells is enhanced by non-transferrin-bound iron

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    Abstract Background Iron overload is associated with liver toxicity, cirrhosis, and hepatocellular carcinoma in humans. While most iron circulates in blood as transferrin-bound iron, non-transferrin-bound iron (NTBI) also becomes elevated and contributes to toxicity in the setting of iron overload. The mechanism for iron-related carcinogenesis is not well understood, in part due to a shortage of suitable experimental models. The primary aim of this study was to investigate NTBI-related hepatic carcinogenesis using T51B rat liver epithelial cells, a non-neoplastic cell line previously developed for carcinogenicity and tumor promotion studies. Methods T51B cells were loaded with iron by repeated addition of ferric ammonium citrate (FAC) to the culture medium. Iron internalization was documented by chemical assay, ferritin induction, and loss of calcein fluorescence. Proliferative effects were determined by cell count, toxicity was determined by MTT assay, and neoplastic transformation was assessed by measuring colony formation in soft agar. Cyclin levels were measured by western blot. Results T51B cells readily internalized NTBI given as FAC. Within 1 week of treatment at 200 μM, there were significant but well-tolerated toxic effects including a decrease in cell proliferation (30% decrease, p Conclusion These results establish NTBI as a tumor promoter in T51B rat liver epithelial cells. Changes in cyclin proteins suggest cell cycle disregulation contributes to tumor promotion by NTBI in this liver cell model.</p
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