174,720 research outputs found
„Forschung wird wieder entblättert“
No full textIhr Forschungsprojekt ist exemplarisch für transdisziplinäres Arbeiten am Collegium Helveticum: Die Historikerin Monika Dommann und der Künstler Hannes Rickli im Gespräch mit Barbara Bleisch über das Projekt Digitale Infrastrukturen und über transdisziplinäres Arbeiten
„Research is unfolding again“ (Übersetzung)
No full textA research project exemplifying the Collegium Helveticum’s transdisciplinary approach: historian Monika Dommann and artist Hannes Rickli talk to Barbara Bleisch about the project Digital Infrastructures and transdisciplinary ways of working
Karte der Alpenländer in 2 Blättern ("Schweiz" und "Ostalpen") aus Stielers Handatlas
No full textbearbeitet von C. Scherrer und H. HabenichtStielers Handatlas, Nr. 14 & 1
Predigt bey der Beerdigung eines den 6ten July 1788 durch einen Strahlstreich getödteten Ehepaars, nemlich Hrn. Rathsherrn Ulrich Knöpfels und Frau Barbara Müllerin, welche beyde Sonntags den 9ten July bey der Pfarrkirche zu Hundweil beerdiget worden sind
No full textgehalten von G. C. Scherrer, Pfarrer daselbs
Miobantia rafaeli Scherrer & Agudelo 2019, sp. nov.
No full text<i>Miobantia rafaeli</i> Scherrer & Agudelo, sp. nov. (Figs 1; 2A–B; 3A–C) <p> <b> Description, <i>male</i>, <i>holotype</i>.</b> <i>Measurements (mm)</i>. Body length 17.2 (from head to tip of abdomen); pronotum, 4.6;</p> <p>metazone, 3.0; forecoxa, 4.0; forewing, 17.4; hindwing, 17.8; maximum width of head, 3.0; prozone at mid-section, 1.1, supracoxal dilatation, 1.7; metazone minimum width, 0.8.</p> <p> <i>Head</i>. Lower frons about twice as wide as its lateral length; tubercle between compound eye and circumantennal sulcus small, indistinct; ocelli medium-sized, central ocellus as elevated as lateral ocellus, distance between lateral and central ocelli equal to lateral ocellus length; vertex slightly convex, distinctly higher than imaginary line joining apex of eyes, with region between parietal sulcus and eye more elevated towards parietal sulcus, slightly convex; parietal sulcus regularly marked; vertex region between parietal sulci laterally abruptly elevated next to parietal sulci, medially following overall outline of lateral part.</p> <p> <i>Pronotum</i>. Surface with moderately long pilosity, supracoxal dilatation 1.55 times as wide as prozone middle width; margins smooth, lacking denticles.</p> <p> <i>Prothoracic legs</i>. Forecoxa markedly longer than metazone. Spination formula: F = 4DS/12AvS/4PvS; T = 9AvS/ 8PvS. Forefemora anteroventral spine 6 with shape and size more similar to spine 5 than spines 2 and 4, distance between anteroventral spines 12 and 11 about same distance as between spines 10 and 11, anteroventral spine 12 about same size of spine 10. Foretibiae with 8 equidistant posteroventral spines, spine 2 very small.</p> <p> <i>Meso- and metathoracic legs</i>: unknown due to specimen damage.</p> <p> <i>Wings</i>: Forewings slightly shorter than hindwings; vein M1 branched; vein CuA1 branches slightly sinuous. Hindwing apical angle about 47°, left vein CuA1 branched, right unbranched; apex rounded.</p> <p> <i>Abdomen:</i> Supraanal plate very short, subrounded, faintly pointed.</p> <p> <i>Genitalia</i> (Fig. 3 A–C): right margin of ventral phallomere with distal process slightly long, thin, apex sharp, fully sclerotized, lacking denticulation; left process faintly sclerotized, markedly projected, long, curved, distinctly turned backwards, with basal portion slightly wider, apex rounded and narrower than base; slit between posterior margin of ventral phallomere and left process deep. Left phallomere with anterior process slightly long, moderately large, markedly curved at its middle, forwardly oriented, its forwardly oriented apex about as wide as in its middle section; expanded portion between anterior process and phalloid apophysis short and forwardly oriented; with strongly sclerotized area between phalloid apophysis and membranous lobe; phalloid apophysis regularly long, slender, its basal portion projected to the left, then continuously curved but straightening apically, not flattened; membranous lobe wide; posterior margin of dorsal lamina with its left portion projected, expanded, uniformly curved.</p> <p> <i>Color:</i> Body entirely dark brown, except limbs and ventral aspect of thorax which are mostly light brown. Head: mouthparts, labrum, clypeus, lower frons, and frontal gena mostly with light brown pigmentation, but cuticle is darker in the central part of these aforementioned sclerites, as well as in mandibles and apex of labial palpi; circumantennal area and scape brown, except for apical dark mark; pedicel and each individual flagellomere brown, centrally darker; dorsal aspect of head dark brown with few, sparse light brown and irregularly-shaped marks of various intensities; vertex and ocellar tubercle with central light brown line. Pronotum: entirely dark brown dorsally, with irregularly-shaped light brown, evanescent marks; margins brown, with dark spots; ventral area light brown, with few, sparse dark spots, and black median stripe on its posterior half. Legs: foreleg mostly light brown, with many dark spots; foretrochanters laterally with few large dark spots, medially with large longitudinal dark mark; forefemora and foretibiae with three large, darkish transverse stripes, which are darker on tibiae; foreleg spines apically darkened; mid- and hindcoxae with dark spots; mid- and hindfemora, tibiae and tarsi unknown due to specimen damage. Wings: mostly dark brown, slightly translucent; apical costal margins, some of the forewing veins, and apical area of hindwing with lighter large marks, not restricted to vein limits; darker marks of forewing present only on main veins, cross-veins without dark spots; forewing vein R with dark spots, with marks of unequal sizes, spaced from each other by 2.0–3.0 times the length of the smallest dark spots.</p> <p> <b> <i>Female, immature stages, and ootheca</i>.</b> Unknown.</p> <p> <b>Variability.</b> Paratype very similar to holotype, except for the foretibiae with posteroventral spine 2 much smaller, almost vestigial; hindwing vein CuA1 of both wings branched. Paratype with left metafemur and tibia preserved, mostly brown, with dark spots; two large darkish, transversal stripes on distal area of hindfemur and on proximal area of hindtibia.</p> <p> <b>Comments.</b> Until the description of <i>Miobantia rafaeli</i> the most distinct diagnostic features of <i>Miobantia</i> was the presence of seven posteroventral spines on the foretibia, and a spineless gap between the first two spines, thus making spine 1 distinctly removed from the others (Fig. 2C). It is even used to identify the genus in the final couplets of the key to the Neotropical genera provided by Terra (1995). <i>Miobantia rafaeli</i> is now the first species to be known for having 8 equidistant posteroventral spines in the foretibia (Fig. 2A & B). It is unlikely that this feature is a morphological anomaly of the specimens studied. In the recent review of the genus, Scherrer (2014) studied 793 males of <i>Miobantia fuscata</i> from 29 different locations, and even though there was some variation in the number of foretibial anteroventral spines, which ranges from 9 to 11, the number of posteroventral spines was consistently seven across specimen. It has also been found that individual anatomical variations are frequently found on only one side of the specimen, very rarely existing the same variation on both sides within the same specimen. In fact, it seems to be the case for the alternative hindwing vein CuA1 branching patterns found in the holotype of <i>M. rafaeli</i> which have the left vein CuA1 branched while the right one is unbranched. The paratype, however, have the vein CuA1 branched in both hindwings, which shows that this is probably the general pattern of the species. By contrast, eight posteroventral spines are present on both foretibiae in all specimens examined, thus reducing the probability of being individual anatomical variations.</p> <p> This species is most similar to <i>Miobantia fuscata</i> based on the general body color, shape, and size, with both forewing vein M1 and hindwing vein CuA1 branched. Because of these features, the couplets leading to <i>M</i>. <i>fuscata</i> in the key to <i>Miobantia</i> spp. (males) provided by Scherrer (2014) will also fit <i>M</i>. <i>rafaeli</i> <i>.</i> However, <i>M</i>. <i>rafaeli</i> can be easily distinguished from <i>M</i>. <i>fuscata</i> by the presence of eight foretibial equidistant posteroventral spines, with spine 2 smaller than the others, and the distal process of the ventral phallomere fully sclerotized, distinctly thinner and sharper than the one of <i>M</i>. <i>fuscata</i> (compare Figs 3B & 3D).</p> <p> <b>Distribution.</b> Brazil. Recorded only from the type locality: Bahia, Berizal.</p> <p> <b>Material Examined.</b> 2 ♂♂. <i>Holotype</i>: ♂ from <b>BRAZIL</b>, BA, Berizal, Fazenda Veredao, -15.2954, - 41.3956.12. xii.2012. J.A. Rafael & E.J. Grossi. (INPA). <i>Paratype</i>: ♂ <b>BRAZIL</b>, BA, Berizal, Fazenda Veredao, - 15.2954, -41.3956.12. xii.2012. J.A. Rafael & E.J. Grossi. (INPA).</p> <p> <b>Etymology.</b> Named after Dr. José Albertino Rafael, one of the most notable Brazilian entomologists, leading advocate for research on Mantodea in Brazil, and collector of the type series.</p>Published as part of <i>Scherrer, Marcus V. & Agudelo, Antonio A., 2019, A new species of Miobantia Giglio-Tos, 1917 with a novel morphological feature (Mantodea: Thespidae: Miobantiinae), pp. 283-286 in Zootaxa 4555 (2)</i> on pages 283-285, DOI: 10.11646/zootaxa.4555.2.10, <a href="http://zenodo.org/record/2624267">http://zenodo.org/record/2624267</a>
How reliable is Ki-67 immunohistochemistry in grade 2 breast carcinomas? A QA study of the Swiss Working Group of breast- and gynecopathologists
No full textAdjuvant chemotherapy decisions in breast cancer are increasingly based on the pathologist's assessment of tumor proliferation. The Swiss Working Group of Gyneco- and Breast Pathologists has surveyed inter- and intraobserver consistency of Ki-67-based proliferative fraction in breast carcinomas.
Methods
Five pathologists evaluated MIB-1-labeling index (LI) in ten breast carcinomas (G1, G2, G3) by counting and eyeballing. In the same way, 15 pathologists all over Switzerland then assessed MIB-1-LI on three G2 carcinomas, in self-selected or pre-defined areas of the tumors, comparing centrally immunostained slides with slides immunostained in the different laboratoires. To study intra-observer variability, the same tumors were re-examined 4 months later.
Results
The Kappa values for the first series of ten carcinomas of various degrees of differentiation showed good to very good agreement for MIB-1-LI (Kappa 0.56–0.72). However, we found very high inter-observer variabilities (Kappa 0.04–0.14) in the read-outs of the G2 carcinomas. It was not possible to explain the inconsistencies exclusively by any of the following factors: (i) pathologists' divergent definitions of what counts as a positive nucleus (ii) the mode of assessment (counting vs. eyeballing), (iii) immunostaining technique, and (iv) the selection of the tumor area in which to count. Despite intensive confrontation of all participating pathologists with the problem, inter-observer agreement did not improve when the same slides were re-examined 4 months later (Kappa 0.01–0.04) and intra-observer agreement was likewise poor (Kappa 0.00–0.35).
Conclusion
Assessment of mid-range Ki-67-LI suffers from high inter- and intra-observer variability. Oncologists should be aware of this caveat when using Ki-67-LI as a basis for treatment decisions in moderately differentiated breast carcinomas
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
A Humanist’s Legacy in Medical Informatics: Visions and Accomplishments of Professor Jean-Raoul Scherrer
No full textSummary
Objective:
To report about the work of Prof. Jean-Raoul Scherrer, and show how his humanist vision, his medical skills and his scientific background have enabled and shaped the development of medical informatics over the last 30 years.
Results:
Starting with the mainframe-based patient-centered hospital information system DIOGENE in the 70s, Prof. Scherrer developed, implemented and evolved innovative concepts of man-machine interfaces, distributed and federated environments, leading the way with information systems that obstinately focused on the support of care providers and patients. Through a rigorous design of terminologies and ontologies, the DIOGENE data would then serve as a basis for the development of clinical research, data mining, and lead to innovative natural language processing techniques. In parallel, Prof. Scherrer supported the development of medical image management, ranging from a distributed picture archiving and communication systems (PACS) to molecular imaging of protein electrophoreses. Recognizing the need for improving the quality and trustworthiness of medical information on the Web, Prof. Scherrer created the Health-On-the-Net (HON) foundation.
Conclusions:
These achievements, made possible thanks to his visionary mind, deep humanism, creativity, generosity and determination, have made of Prof. Scherrer a true pioneer and leader of the human-centered, patient-oriented application of information technology for improving healthcare.</jats:p
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