1,720,992 research outputs found
Dominique Joubert
No full textJoubert Dominique, Minvielle Marie-Claire, Ramadier Régine. Dominique Joubert. In: Diplômées, n°193, 2000. 80ème anniversaire 1920-2000. p. 106
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Abstract LB-127: Progastrin: a specific early cancer screening biomarker and a breakthrough innovative cancer target
No full textAbstract
Background and aims: Because we are lacking effective screening tests, most cancers are detected in late stages, when survival rates are very low. Furthermore, despite the recent approval of targeted therapies, chemotherapy remains the cornerstone of treatment for patients suffering from these late stage cancers, such as metastatic colorectal cancer (mCRC) regardless of very low survival. Here, we show the development of the first early cancer screening test for multiple cancers using progastrin as biomarker and of the First-in-class immunotherapeutic humanized monoclonal antibody targeting progastrin and describe its therapeutic efficiency in colorectal cancer.
Methods: Monoclonal antibodies of murine or humanized origin directed against progastrin were produced and selected for target specificity and affinity. Selected antibodies were either used to set up an ELISA sandwich to detect progastrin in the blood of patients with various types of cancers or validated depending on their effectiveness to regulate tumor cell growth, death and invasion in CRC cell lines mutated for BRAF or KRAS. In vitro and in vivo quantification of their efficacy was assessed, alone or concomitantly with chemotherapy, on cancer stem cells (CSCs) self-renewal capacity, tumor recurrence and Wnt signaling.
Results: Increased levels of progastrin were detected in the blood of patients with various types of cancers even at early stages. Furthermore, in CRC, a boost of progastrin was detected in patients treated with chemotherapy as well as in CRC cells after chemotherapy and hypoxia-promoting conditions exposure, confirming the relevance of targeting progastrin in CRC patients under treatment. Humanized progastrin antibodies produced an intense decrease of self-renewal of CSCs both in vitro and in vivo, either alone or concomitantly with chemotherapy. Chemosensitivity was prolonged significantly and post-treatment relapse was delayed significantly as well in mice who had received multiple rounds of chemotherapy in progastrin antibody treatment conditions. Furthermore, the Wnt signaling activity in vitro was decreased, the tumor burden was alleviated, and there was an amplification in tumor differentiation in the intestine of Wnt-driven transgenic mouse neoplasia mice, all due to progastrin antibodies. Finally, 20 weeks of treatment with progastrin antibodies did not induce any alteration of organs or behavior in the treated mice.
Conclusion: Taken together, the results presented here show that using progastrin as a biomarker for early cancer screening is an outstanding opportunity and that humanized progastrin antibodies alongside chemotherapy represent an extremely useful therapeutic tool allowing to target cancer stem cells while reducing the recurrence of tumors in advanced CRC.
Citation Format: Alexandre Prieur, Dominique Joubert. Progastrin: a specific early cancer screening biomarker and a breakthrough innovative cancer target [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr LB-127. doi:10.1158/1538-7445.AM2017-LB-127</jats:p
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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