7 research outputs found
Le Gisement de Kharaneh IV. Note sommaire sur la phase D
No full textThe main characteristics of Kharaneh IV, D phase (Transjordanian plateau) are presented in this brief note. This phase is ascribed by the author to the Geometric Kebaran horizon.Sont présentées ici les principales caractéristiques de la phase D du gisement de Kharaneh IV (plateau transjordanien) attribuée par l'auteur au Kébarien géométrique.Muheisen Mujahed. Le Gisement de Kharaneh IV. Note sommaire sur la phase D. In: Paléorient, 1988, vol. 14, n°2. Préhistoire du Levant II. Processus des changements culturels. pp. 265-269
Assessing the Knowledge and Risk Awareness about over-the-counter (OTC) Supplements use for Children Aged 2-10 Years in Bethlehem City: Cross Sectional Study
No full textThe increasing global demand for over-the-counter (OTC) supplements for children without real medical needs or prescriptions is a topic of debate, raising questions about their necessity and the extent to which they are used. Some studies support their use, while others are against it. However, there is a lack of similar studies regarding their use in Palestine
Effect of elastomeric bridge bearings on fatigue cracking of supporting steel members
No full textThis study investigated the root cause behind unique fatigue cracking in the upper flange of the floor beam of a bridge with steel superstructure and concrete deck, particularly at the bolt holes of the replacement elastomeric bearings under stringers, following a major deck rehabilitation. Such rehabilitation is common for extending service life of highway bridges. The replacement bearing assembly was restrained to the floor beam upper flange using high strength bolts that were specified to be pretensioned to 35 kips. The critical stresses in the floor beam upper flange and the bearing assembly under the stringer due to AASHTO HL-93 loading were determined by 3D FEA of a local model of the structure including a part of the stringer, the elastomeric bearing assembly under the stringer and part of a floor beam. The reinforced elastomeric bearing was modeled including the elastomer layers and the reinforcing steel shims. The elastomer material was modeled as incompressible and hyper elastic. Effect of bolt pretension was considered.
The analyses demonstrated that the main reason for the cracking of the floor beam upper flange and bolt fracture was pretensioning of the high strength bolts in the elastomeric bearing system. Deformation of the bearings under live load introduced bending and high cyclic stresses in the bolts that led to fatigue cracking from the root of the bolt threads. The large stress range in the bolts also introduced high stress ranges in the floor beam upper flange around the bolt holes, and at the end of the bearing stiffener-to-flange connection, leading to fatigue cracking. Among several retrofit options evaluated for mitigating the observed cracking, releasing the pretension of the elastomeric bearing bolts was found to be the most cost effective. The efficacy of this retrofit was further verified by investigating crack propagation under live load employing 3D FEA. Based on this research it is recommended that elastomeric bridge bearings and its assembly, while becoming increasingly popular in recent years, should be adequately detailed to prevent unintended consequences due to their interaction with the supporting steel members.M.S.Includes bibliographical reference
Development of Synbody Peptides for PD-L1 Blockade for use as a Cancer Vaccine Adjuvant
No full textabstract: PD-L1 blockade has shown recent success in cancer therapy and cancer vaccine regimens. One approach for anti-PD-L1 antibodies has been their application as adjuvants for cancer vaccines. Given the disadvantages of such antibodies, including long half-life and adverse events related to their use, a novel strategy using synbodies in place of antibodies can be tested. Synbodies offer a variety of advantages, including shorter half-life, smaller size, and cheaper cost. Peptides that could bind PD-L1 were identified via peptide arrays and used to construct synbodies. These synbodies were tested with inhibition ELISA assays, SPR, and pull down assays. Additional flow cytometry analysis was done to determine the binding specificity of the synbodies to PD-L1 and the ability of those synbodies to inhibit the PD-L1/PD-1 interaction. Although analysis of permeabilized cells expressing PD-L1 indicated that the synbodies could successfully bind PD-L1, those results were not replicated in non-permeabilized cells. Further assays suggested that the binding of the synbodies was non-specific. Other tests were done to see if the synbodies could inhibit the PD-1/PD-L1 interaction. This assay did not yield any conclusive results and further experimentation is needed to determine the efficacy of the synbodies in inhibiting this interaction
Author Correction: A novel MPPT design based on the seagull optimization algοrithm for phοtovοltaic systems operating under partial shading
No full textClassification of online toxic comments using the logistic regression and neural networks models
No full textThe paper addresses the questions of abusive content identification in the Internet. It is presented the solving of the task of toxic online comments classification, which was issued on the site of machine learning Kaggle (www.Kaggle.com) in March of 2018. Based on the analysis of initial data, four models for solving the task are proposed: logistic regression model and three neural networks models - convolutional neural network (Conv), long shortterm memory (LSTM), and Conv + LSTM. All models are realized as a program in Python 3, which has simple structure and can be adapted to solve other tasks. The results of the classification problem solving with help of proposed models are presented. It is concluded that all models provide successful solving of the task, but the combined model Conv + LSTM is the most effective, so as it provides the best accuracy. © 2018 Author(s)
Estimate the absolute efficiency by MATLAB for the NaI (Tl) detector using IAEA-314
No full textThis works amid to calculating the absolute efficiency at any interesting γ-energy in the energy range between 10 and 1764 keV. by using fit function which has been developed to calculate theoretically the absolute γ-ray detection efficiencies of a cylindrical NaI(Tl) crystal. Efficiency of the NaI(Tl) calculator is a program built in MATLAB by the author of this paper to make it easier to calculate the efficiency of standard source. The absolute γ-ray detection efficiencies have been calculated for detectors 3? x 3? inches NaI(Tl) crystal. The absolute efficiency of the NaI (Tl) detector was calculated using standard sources (IAEA-314) which have known activity of 226Ra (732 Bqkg-1) and 232Th (17.8 ppm). In this calculation, experimental and theoretical efficiencies have been calculated. The uncertainties of efficiency calibration have been calculated also for quality control. Measurements were performed with calibrated point source. Gamma-ray energies under consideration were 0.356, 0.662, 1.17 and 1.33 MeV. Efficiency function was obtained by applying Weibull Model equation to the experimental efficiency data which give Best agreement between experimental and theoretical absolute detection efficiencies of 3×3-inch detector for gamma energy. © 2019 Author(s)
