1,721,121 research outputs found
Antiretroviral therapy among HIV-infected persons in northeastern Vietnam : impact of peer support on virologic failure and mortality in a cluster randomized controlled trial
No full textBackground: Wide access to antiretroviral therapy (ART) has substantially improved the prognosis of patients living with HIV/AIDS (PLHIV). However, in resource-limited countries, sustaining ART programs to prevent drug resistance and treatment failure and to maximize the existing human resources is still challenging. In 2010, Vietnam had 254,000 PLHIV and 52,000 people accessed ART. Viral load (VL) testing has not been routinely performed for monitoring treatment failures due to the high cost and the necessity of advanced laboratory equipment. Peer support has been proven to improve quality of life, reduce stigma and to improve adherence to treatment. However, there is little known about the impact of peer adherence support on ART outcomes. The overall aim of this study was to assess the impact of peer support on virologic and immunologic treatment outcomes and mortality among HIV-infected patients by monitoring routinely a simple- and low- cost VL in a cluster randomized controlled trial in Quang Ninh, Vietnam. The primary outcome was virologic failure rate between intervention and control group.Methods: A total of 640 HIV-infected patients recruited from 59 clusters (communes) were randomized into either intervention or control group. Both groups received first-line ART regimens according to the National Treatment Guidelines and were followed up for 24 months. Viral load (ExaVirTM Load) and CD4 counts were measured every 6 months. Patients in the intervention group received enhanced adherence support by 14 peer supporters. Survival analyses with Kaplan-Meier curve and Cox proportional hazard model were used to identify survival rate and risk factors for deaths. Causes of death were assessed through medical records and verbal autopsy questionnaire. Cluster longitudinal and survival analyses with intention-to-treat were used to study time to virologic failure and CD4 trends and to compare between the intervention and control groups. At baseline, we monitored the spread of infection and prevalence of transmitted drug resistance mutations (TDRMs) by analyzing 63 1000bp pol-gene sequences generated from 63 treatment-naïve HIV-1 CRF01_AE patients. Through the cohort, we determined the feasibility, sensitivity and specificity of ExaVir Load in 605 HIV treatment-naïve patients and compared the correlation and agreement of 60 samples between Roche Cobas TaqMan® VL and ExaVir Load.Results: After 24 months of follow-up, 78% of the patients remained in the study, mortality rate was 11% (6.4/100 person-years), cumulative virologic failure rate (VL >1,000 copies/ml) was 7.2% and the median CD4 increase was 286 cells/μl. There were no significant differences between intervention and control groups in virologic failure rates (VL >1,000 copies/ml) [6.9% vs 7.5%, respectively, RR 0.93; (95%CI: 0.13-6.54), p=0.94], in the time to virologic failure [HR 1.0; (95%CI 0.5-1.7), p=0.94], in CD4 trends [Coeff. (95%CI: 0.2(-0.6;-0.9), p=0.69] and in mortality (Log-rank p=0.79). Risk factors for virologic failure were ART-non-naïve status [aHR 6.9;(95%CI 3.2-14.6); p100,000 copies/ml [aHR 2.3;(95%CI 1.2-4.3); p35 years, clinical stage 3 or 4, body mass index (BMI) 100,000 copies/ml. The TDRMs including Y181C, L210W, L74I and V75M were found in 4/63 patients (6.3%). Phylogenetic analysis for calculating the time of the most recent common ancestor (tMRCA) was shown in two distinct groups: the small group (n=3) had tMRCA in year 1997.5 and the larger group had tMRCA in 1989.8. The ExaVir Load and the Roche Cobas TaqMan showed a strong correlation (r2 =0.97), high agreement (log difference =0.34; 95% CI -0.35;1.03), high sensitivity (98%) and high specificity (100%).Conclusions: Enhanced adherence intervention by peer support had no impact on virologic failure and CD4 trends as well as on mortality after 24 months of ART initiation. Early deaths occurred among patients presented late to ART and majority of deaths were attributable to TB. Baseline VL >100,000 copies/ml was a predictive factor for virologic failure, CD4 changes and mortality. Transmitted drug resistance rate should be monitored regularly and prospectively in Vietnam. Using ExaVir Load is feasible to monitor efficacy of ART programs in resource-limited settings.List of scientific papersI. Irene Bontell, Do Duy Cuong, Eva Agneskog, Vinod Diwan, Mattias Larsson, Anders Sönnerborg. Transmitted drug resistance and phylogenetic analysis of HIV CRF01_AE in Northern Vietnam. Infection, Genetics and Evolution. 2012; 12(2):448-452. https://doi.org/10.1016/j.meegid.2011.04.034 II. Do Duy Cuong, Anna Thorson, Anders Sönnerborg, Nguyen Phuong Hoa, Nguyen Thi Kim Chuc, Ho Dang Phuc, Mattias Larsson. Survival and causes of death among HIV-infected patients starting antiretroviral therapy in north-eastern Vietnam. Scandinavian Journal of Infectious Diseases. 2012; 44(3):201-208. https://doi.org/10.3109/00365548.2011.631937 III. Do Duy Cuong, Eva Agneskog, Nguyen Thi Kim Chuc, Michele Santacatterina, Anders Sönnerborg, Mattias Larsson. Monitoring the efficacy of antiretroviral therapy by a simple reverse transcriptase assay in HIV-infected adults in rural Vietnam. Future Virology. [Accepted] https://doi.org/10.2217/FVL.12.83 IV. Do Duy Cuong, Anders Sönnerborg, Vu Van Tam, Ziad El Khatib, Michele Santacatterina, Geatano Marrone, Nguyen Thi Kim Chuc, Vinod Diwan, Anna Thorson, Pham Nhat An, Mattias Larsson. Impact of two-year peer support on virologic failure in HIV-infected patients on antiretroviral therapy - A randomized controlled trial in Vietnam. [Manuscript]</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
3D UAV trajectory and data collection optimisation via deep reinforcement learning
No full textUnmanned aerial vehicles (UAVs) are now beginning to be deployed for enhancing the network performance and coverage in wireless communication. However, due to the limitation of their on-board power and flight time, it is challenging to obtain an optimal resource allocation scheme for the UAV-assisted Internet of Things (IoT). In this paper, we design a new UAV assisted IoT system relying on the shortest flight path of the UAVs while maximising the amount of data collected from IoT devices. Then, a deep reinforcement learning-based technique is conceived for finding the optimal trajectory and throughput in a specific coverage area. After training, the UAV has the ability to autonomously collect all the data from user nodes at a significant total sum-rate improvement while minimising the associated resources used. Numerical results are provided to highlight how our techniques strike a balance between the throughput attained, trajectory, and the time spent. More explicitly, we characterise the attainable performance in terms of the UAV trajectory, the expected reward and the total sum-rate
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Effect of attitudes towards traffic safety and risk perceptions on pedestrian behaviours in Vietnam
No full textThis study explores the relationships between attitudes towards traffic safety, risk perceptions and pedestrian behaviours in Vietnam. A questionnaire survey was conducted with a sample of 835 Vietnamese road users. The results from regression analyses and a structural equation model showed that safer attitudes towards traffic safety and higher levels of traffic risk perception are associated with safer pedestrian behaviours. In addition, traffic safety attitudes were found to partially mediate the association between traffic risk perception and pedestrian behaviour. Furthermore, traffic risk perception was significantly predicted by non-traffic risk perception, and people who had higher level of risk perceptions of both kinds were also prone to report safer attitudes towards traffic safety. The practical implications for traffic safety interventions in Vietnam are also discussed.</p
- …
