260 research outputs found
Hypocapnia correction as a working mechanism for breathing retraining in asthma – authors' reply
No full textRefers to: Alex Jan van 't Hul, Duco D Deenstra, Remco S Djamin, Jeanine C Antons, Hanneke A van Helvoort'Hypocapnia correction as a working mechanism for breathing retraining in asthma', The Lancet Respiratory Medicine, Volume 6, Issue 4, April 2018, Pages e14Anne Bruton, Amanda Lee, Lucy Yardley, James Raftery, Emily Arden-Close, Sarah Kirby, Shihua Zhu, Manimekalai Thiruvothiyur, Frances Webley, Lyn Taylor, Denise Gibson, Guiqing Yao, Mark Stafford-Watson, Jenny Versnel, Michael Moore, Steve George, Paul Little, Ratko Djukanovic, David Price, Ian D Pavord, Stephen T Holgate, Mike Thomas'Physiotherapy breathing retraining for asthma: a randomised controlled trial', The Lancet Respiratory Medicine, Volume 6, Issue 1, January 2018, Pages 19-28Referred to by:Alex Jan van 't Hul, Duco D Deenstra, Remco S Djamin, Jeanine C Antons, Hanneke A van Helvoort'Hypocapnia correction as a working mechanism for breathing retraining in asthma' The Lancet Respiratory Medicine, Volume 6, Issue 4, April 2018, Pages e1
Revision_Online_supplement_FatigueCOPD_Ther_Adv_Resp_Dis_YMJGoertz_3April2019 – Supplemental material for Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation
No full textSupplemental material, Revision_Online_supplement_FatigueCOPD_Ther_Adv_Resp_Dis_YMJGoertz_3April2019 for Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation by Yvonne M. J. Goërtz, Martijn A. Spruit, Alex J. Van ‘t Hul, Jeannette B. Peters, Maarten Van Herck, Nienke Nakken, Remco S. Djamin, Chris Burtin, Melissa S. Y. Thong, Arnold Coors, Yvonne Meertens-Kerris, Emiel F. M. Wouters, Judith B. Prins, Frits M. E. Franssen, Jean W. M. Muris, Lowie E. G. W. Vanfleteren, Mirjam A. G. Sprangers, Daisy J. A. Janssen and Jan H. Vercoulen in Therapeutic Advances in Respiratory Disease</p
The Effects of Long-term Macrolide Therapy in COPD Patients with Frequent Exacerbations
No full textExacerbations of chronic obstructive pulmonary disease (COPD) have a major impact on lung function, morbidity and mortality. Macrolide antibiotics have been successfully used as maintenance treatment in several chronic inflammatory pulmonary diseases. We demonstrated that a regimen of azithromycin treatment 500 mg three times a week during one year compared to placebo, leads to a larger reduction in exacerbation frequency in COPD patients with a minimum of three exacerbations in the previous year. We investigated the role of viral infections. We found a viral infection in a quarter of exacerbations. It was found that human rhinovirus (HRV) was most prevalent with a peak in July. COPD patients with frequent exacerbations showed the best response to maintenance treatment with azithromycin in patients with the following characteristics: baseline blood eosinophil count ≥ 2.0% (compared to an eosinophil count < 2.0%), GOLD stage 1-2 (versus GOLD stage 4) and GOLD group C (compared to group D).
We determined the effect of azithromycin maintenance therapy on the dynamics of macrolide resistance genes in the pharyngeal microbiota. It was shown that the acquisition of macrolide resistance genes was limited but the relative abundance of macrolide resistance genes increased significantly over time compared to placebo
"Can do" versus "do do": A Novel Concept to Better Understand Physical Functioning in Patients with Chronic Obstructive Pulmonary Disease
No full textContains fulltext :
203249.pdf (Publisher’s version ) (Open Access)10 p
Design Considerations for Building a Scalable Digital Version of a Multi-player Educational Board Game for a MOOC in Logistics and Transportation
No full textWith more flexible and large-scale learning environments, new design requirements for games emerge. Massive Open Online Courses (MOOCs) are one of the most important innovations in the learning field. Still, it is a challenge to motivate learners and to keep them motivated in such huge learning environments. To address this challenge, we redesigned a board game targeting at an integrated view on disruption and communication management in an intermodal transportation situation. From the redesign, we have learned that an online game works better with fewer roles, requires immediate feedback, and an engaging way of challenge to keep players motivated. Our findings can inform the design of games for large groups of players in an online environment.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Policy AnalysisOrganisation & Governanc
Using space syntax to assess accessibility of multimodal urban hubs and seamless mobility within the hubs Case study Delft-Campus train station
No full textMultimodal hubs connect different modes, allowing people to switch from one mode to another and seamlessly access/egress to/from their origin/destinations. However, there are limited methods to estimate the impact of future measures on the accessibility of multimodal hubs. These future measures could be wide reaching, among others, introduction of different schemes in the planning of the hub or introduction of new modes at multimodal hubs. This study provides interdisciplinary cross-cutting method including transport and urbanism literatures, by using Space Syntax method. This method allows the transport planners to analyse and compare the current situation and the proposed development plan. In this research, we show how changes made in urban spatial configuration can impact the accessibility of intermodal hubs. To learn about the impacts of the spatial configuration of a city on station design, we performed a case study at Delft Campus train station in the Netherlands, which is under construction to become a multimodal hub. Firstly, we analyse the current situation and then the proposed development plan in terms of, integration, choice, accessibility and intelligibility, using segment analyses. Furthermore, the immediate surrounding areas of the station have been analysed by Visual Graphic Analysis to find visual accessibility within the hub. Although the municipality proposed plans claim that the station’s accessibility would be enhanced, our method indicate otherwise and the proposed changes are not highly effective in increasing accessibility. Finally, some design recommendations for multimodal hubs are proposed. This study is a prerequisite for designing the multimodal hubs considering emerging modes.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Transport and PlanningTransport and Plannin
Erratum: Corrigendum to “Development and initial validation of the Role Strain Questionnaire for Junior Athletes (RSQ-JA)” (Psychology of Sport and Exercise (2016) 24 (168–178)(S146902921630022X)(10.1016/j.psychsport.2016.02.004))
No full textThe authors regret to let us know that there is an authorship change in the article. The authors would like add another author to the article namely Fiona Chun Man Ling, as they believe that she has made a substantial intellectual contribution to this work and is deserving authorship. As such, they would like to change the reference of the article to: Fleur E.C.A. van Rens a, *, Erika Borkoles b, Damian Farrow a, c, Thomas Curran d, Fiona Chun Man Ling a, Remco C.J. Polman e The authors would like to apologise for any inconvenience caused
Measuring microfinance access : building on existing cross-country data
No full textGiven the acknowledged need for a new effort to expand the set of available data on direct access to financial services, including a focus on access by those at low income, Honohan provides a selective review of the diverse sources of data that exist and considers how best to build on them. He proposes a basic framework within which to consider the analysis of the interesting questions: (1) How does access affect poverty and productivity? and (2) What hinders access? The author discusses existing and potential contribution of household and business user surveys, surveys of providers and their regulators, and surveys of experts, and assesses their relative strengths.Banks&Banking Reform,Environmental Economics&Policies,Health Economics&Finance,Poverty Assessment,Governance Indicators
Development of a scale to measure social capital in recreation and sport clubs
No full textSocial capital's measurement has been limited and an effective scale is needed. This research employed focus groups and interviews and a panel of experts to provide understanding and items for a social capital scale in sport and recreation setting. After a pilot study the Club Social Capital Scale (CSCS) was completed by 1,079 members of sport and recreation clubs. This 42-item scale included the factors trust, friendship, acceptance, reciprocity, norms, and governance. Exploratory factor analysis resulted in a 20-item four component (governance, norms, friendship-acceptance, and trust-reciprocity) CSCS. Confirmatory factor analysis confirmed the potential four or five factor model and the hierarchical structure. The CSCS is the first psychometrically developed instrument to measure the factors underlying social capital rather than its outcomes. It can inform policy makers or sport and recreation administrators to establish baseline social capital in their organization and the efficacy of interventions or changes in policy. © 2018, © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2018, © Tom Forsell, John Tower, and Remco Polman
Quenched Central Limit Theorems for the Ising Model on Random Graphs
No full textThemain goal of the paper is to prove central limit theorems for the magnetization
rescaled by the square root of N for the Ising model on random graphs with N vertices.Both random quenched
and averaged quenched measures are considered.We work in the uniqueness regime β > βc
or β > 0 and B not equal to 0, where β is the inverse temperature, βc is the critical inverse temperature
and B is the external magnetic field. In the random quenched setting our results apply to
general tree-like random graphs (as introduced by Dembo, Montanari and further studied by
Dommers and the first and third author) and our proof follows that of Ellis in Z^d. For the
averaged quenched setting, we specialize to two particular random graph models, namely
the 2-regular configuration model and the configuration model with degrees 1 and 2. In
these cases our proofs are based on explicit computations relying on the solution of the one
dimensional Ising model
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