3,367 research outputs found
Le egloghe di Niccolò da Correggio nel ms. Harley 3406: rapporti e contesti
No full textIl contributo analizza le egloghe incluse nel ms. Harley 3406 della British Library, principale testimone del corpus poetico di Niccolò da Correggio (autore noto per la significativa componente “bucolica” dei suoi testi lirici, ma di cui non si è finora studiata la poetica eglogistica vera e propria). L’analisi dei tratti formali e di alcuni contatti intertestuali di questi testi porterà a ipotesi sui modelli seguiti e sugli autori che a loro volta avrebbero guardato a Niccolò come modello – una situazione che caratterizza soprattutto il soggiorno milanese del poeta (1490-1497), che fu al centro di una rete di contatti letterari sulla quale si proverà a far emergere nuovi dettagli.The contribution examines the eclogues included in ms. Harley 3406 (Bri-
tish Library), the main testimony of the poetical corpus of Niccolò da Cor-
reggio (an author more known for the “bucolic” touch of his lyric poetry
than as an author of fully-fledged eclogues). The analysis of the formal
traits of these poems, as well as of some intertextual knots, will allow
hypotheses on Correggio’s models and on his own role as model for other
authors. The latter situation seemingly applied, in particular, in the period
Correggio spent in Milan (1490-1497), where he became the centre of a
network of poets that will here be partly reassesse
AN LC-MS/MS METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTIFICATION OF ANTIVIRAL DRUGS IN PLASMA SAMPLES
No full textObjective: A reliable and specific LC-MS/MS method was developed and validated for the simultaneous quantification of cabotegravir (CBTG) and rilpivirine (RLPV) in plasma samples.
Methods: Chromatographic separation was achieved on a Hypersil BDS C18 (50 × 4.6 mm, 5 µm) column maintained at 35 °C. The mobile phase consisted of 0.1% HCOOH, acetonitrile, and methanol in the ratio 10:80:10 (v/v/v). The injection volume was 10 µl**, and the autosampler temperature was maintained at 10 °C. The retention times for RLPV, internal standard, and CBTG were 2.00, 3.20, and 5.15 min, respectively.
Results: Accuracy ranged from 96.32% to 98.19% for CBTG and 95.57% to 97.00% for RLPV. The intra-and inter-day precision values were 0.39%–3.82% RSD for CBTG and 1.56%–4.55% RSD for RLPV mean recovery values at three QC levels were 96.14%–97.70% for CBTG and 96.06%–97.75% for RLPV. All stability assessments were within acceptance criteria.
Conclusion: The method is robust for the quantitative determination of CBTG and RLPV in biological samples and is suitable for application in forensic, quality-control, bioavailability, and bioequivalence studies
Stenography compleated, or the art of short-hand brought to perfection; being the most easy, exact, speedy and legible method extant: whereby can be joined in every sentence, at least two, three ... seven, or more words together in one, without taking off ye pen ...
No full textEach part has separate t.-p.Mode of access: Internet.Cogwell.Autograph note of author. Ms. extract, and clipping, from the Journal des scavants, and book plate of G. Haillet inserted
SALDI-MS of real world samples
No full textSurface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is a method of mass spectrometry, ideal for the low mass range, as it reduces fragmentation and helps with clarity of sample analysis. Projected applications of this technology can be seen in medical and drug research.
• Quinine is a small, organic biomolecule (molecular weight 325 g/mol) that is derived from the bark of the cinchona plant. Native to the Americas, is historically used as an anti-malaria, but in recent years has emerged in drug analyses of heroin. Dealers dilute the sample in quinine, which has a similar bitter taste, as a way to conserve supply.
Due to its variety of functional groups and reactive units, quinine has many side effects. As of April 2019, the FDA limits quinine to 83ppm in beverage samples. Coupled with its increased use in illegal drugs and its regulated recreational use, a new, quick and easy method of detection is needed for its analysis.
• Quinine is commonly found dissolved in carbonated beverages to make tonic water.
• Transition metal oxide (TMOs) nanoparticles are used in SALDI-MS because they require minimal sample preparation, have large surface area to sample rations (which helps with desorption/ionization), and they are compatible with a wide range of different samples
UHPLC-MS/MS based comprehensive phenolic profiling, antimicrobial and antioxidant activities of Indian Rhodomyrtus tomentosa fruits
No full textAbstract Rhodomyrtus tomentosa fruits, endemic to the Western Ghats were analyzed for its free, bound and esterified phenolics by Ultra High Performance Liquid Chromatography–Mass Spectrometry. Overall, twenty-nine phenolic compounds were identified, amongst them 18 were detected in this fruit for the first time. Gallic acid (80.44 ± 8.74 mg/100 g) and ellagic acid (107.47 ± 7.28 mg/100 g) were the most prominent ones found in the bound phenolic fraction and gallic acid (103.76 ± 6.34 mg/100 g) in the esterified phenolic fraction of the fruit, respectively. Total Phenolic content was found to be highest in bound phenolics (7.09 ± 0.17 mg Gallic acid equivalent/g). The antioxidant and antimicrobial activities of the three extracts namely free, bound and esterified phenolic fruit fractions have been analyzed. Bound phenolics exhibited the highest antioxidant potential (DPPH-15.63 ± 0.86; ABTS-34.73 ± 0.07; FRAP-17.89 ± 0.27 mg/g Ascorbic acid equivalent). The bound phenolics showed good antimicrobial activity against Bacillus cereus, Staphylococcus aureus and Escherichia coli with a MIC of 0.156, 0.625 and 1.25 mg/mL respectively. The exploration of phenolic compounds in Indian variety of Rhodomyrtus tomentosa fruits may provide useful insights on its utilization as a functional food ingredient
Evaluate binding properties of synthetic berbamine derivatives with the PDGFR-beta G-quadruplex by ESI-MS
No full textPotent G-quadruplex ligands are of great importance to the regulation of G-quadruplex biological functions. Prior to this study, we have found a potential G-quadruplex binder named berbamine from traditional Chinese medicine with moderate binding affinity and stabilization effect on the PDGFR-beta G-quadruplex. To further optimize its binding property, ten berbamine derivatives were designed and synthesized in this study. Characterization of the binding properties using ESI-MS demonstrated that eight derivatives displayed remarkably improved binding affinity and stabilization effects on the PDGFR-beta G-quadruplex, and bba3Py was the most outstanding one. Our derivatization strategy successfully transformed the less effective G-quadruplex ligand to a much more potent binder for the PDGFR-beta G-quadruplex. Thus, the study provided important clues for the optimization of less potent G-quadruplex binders screened from natural products. (C) 2015 Elsevier B.V. All rights reserved.973 Program [2012CB720600, 2012CB720601]; National Natural Science Foundation of China [21372021]SCI(E)[email protected]; [email protected]
HETERONORMATIVITY IN MS. MARVEL COMICS
No full textThe main subject of this study is the implementation of traditional masculinity and femininity theories within the Heteronormativity framework in 3 sequential volumes of Ms. Marvel by author G. Willow Wilson. The author relies on a post-structuralist feminist framework to describe gender stereotypes, using content analysis methods, which are mixed-methods quantitatively and qualitatively. This thesis attempts to answer a fundamental question; How Gender Stereotypes were presented in Ms. Marvel Comics?. In this findings, the data that have been collected shows significant differences in the distribution of social role attributes, traits, behaviors in characters divided into categories of masculine and feminine attributes. These quantitative data are then processed. Masculine attributes still dominated by male characters, and vice versa. , Nevertheless, there were at least a total of 67% (n=4) of female characters who were more associated with masculine attributes
Fluoxetine as disease modifying treatment in multiple sclerosis : rationale, evaluation of the use of MRI to monitor treatment, and preliminary findings
No full textPatients with multiple sclerosis (MS) lack astrocytic β2-adrenergic receptors and this may contribute to the focal inflammatory demyelinating lesions and axonal degeneration that characterize this disease. We hypothesized that the antidepressant fluoxetine might be able to compensate for the loss of the β2-adrenergic receptors. In this thesis we evaluated the use of cerebral MRI scans to monitor disease activity and we performed several exploratory studies to evaluate effects of fluoxetine on patients with MS.
A convenient way to find out whether a drug is able to reduce disease activity in MS is by measuring the development of new focal lesions on serial MRI scans of the brain.
MS patients who received fluoxetine during 6 months had a trend towards the development of less new focal lesions compared to patients receiving placebo. To assess whether preventing new lesions formation reduces disability on the long term, we studied the relationship between the focal (T2) lesions and disease progression. The number of focal lesions predicted progression of disability and conversion to a progressive disease course in patients with relapsing remitting MS. However, once patients had entered the progressive phase, T2 lesions were no longer predictive for further progression of disability. In another study, we found that 2 weeks use of fluoxetine resulted in an increase in NAA/Cr (a marker of axonal function) in the white matter of MS patients.
These preliminary studies suggest that fluoxetine reduces new focal lesion formation and may improve axonal metabolism in MS patients.
Sewing the Body of Christ : Eucharist wafer souvenirs stitched into fifteenth-century manuscripts, primarily in the Netherlands
No full textBooks of hours in the fifteenth century occupied several social and devotional roles. People used them to store small objects, including metal badges. Although the cultural practice of sewing in badges was widespread in the late Middle Ages, nearly all of the badges were removed (by later collectors). This article examines the practice by considering needle holes and offsets in the soft parchment, which indicate the shape of the badges and where they were attached. Noting that vast majority of metal offsets in books of hours are round, the author posits that these were not impressed by pilgrims’ badges, as is often repeated in the scholarly literature, but rather by tokens that commemorate having taken the Eucharist. The round badges are the same size and shape and bear the same imagery as host wafers. Owners stitched such badges into their books’ margins at locations relevant to Eucharistic piety. When they were sewn into books, Eucharist badges reconfigured the book as a shrine that recorded a votary’s pursuit of Communion.Peer reviewe
Simulation modelling is 50! Do we need a reality check?
No full textimulation modelling is a fascinating research field. The techniques and tools of simulation modelling have been used to research and investigate the behaviour of various systems in a wide range of areas such as commerce, computer networks, defence, health, manufacturing and transportation. Indeed, the study of the use of these techniques and tools, and the development of new forms of these, are a rich source of research in their own right. Simulation modelling is about to reach the 50th anniversary of the development of GSP (General Simulation Program), the first simulation modelling language (Tocher and Owen, 1960). There have been several historical accounts of simulation modelling research. To complement these, we have performed a review of the recent history of simulation modelling. This study targeted three leading journals dedicated to this field. These are the ACM Transactions of Modeling and Computer Simulation, Simulation: Transactions of The Society for Modeling and Simulation International and Simulation Modelling Practice and Theory (formerly Simulation Practice and Theory). The study covered the first 6 years of this century (2000–2005) and included 576 papers. The key observation of this work was the relative lack of 'real world' involvement in simulation modelling research and an even greater lack of evidence of 'real world' benefit, arguably very alarming outcomes for an applied field. To further investigate this observation two additional surveys were carried out, one to study if real world papers appeared in the more widely known OR/MS literature (837 papers in 12 journals) and one to study if such papers appeared in Manufacturing and Logistics, an application area closely associated with simulation modelling (1077 papers in 10 journals). The results of these surveys confirmed our observations. We ask if this is the natural evolution of a field that has existed for half a century or an indication of a worrying problem? This paper reports on our findings and discusses whether or not simulation modelling research urgently needs to face a 'reality check.
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