36,473 research outputs found
A 2 h periodic variation in the low-mass X-ray binary Ser X-1
No full textSpectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
1ST MEASUREMENT OF GAMMA(D(S)(+)-]MU+NU)/GAMMA(D(S)(+)-]PHI-PI+)
No full textComplete Author List:
ACOSTA D, ATHANAS M, MASEK G, PAAR H, BEAN A, GRONBERG J, KUTSCHKE R, MENARY S, MORRISON RJ, NAKANISHI S, NELSON HN, NELSON TK, RICHMAN JD, RYD A, TAJIMA H, SCHMIDT D, SPERKA D, WITHERELL MS, PROCARIO M, YANG S, BALEST R, CHO K, DAOUDI M, FORD WT, JOHNSON DR, LINGEL K, LOHNER M, RANKIN P, SMITH JG, ALEXANDER JP, BEBEK C, BERKELMAN K, BESSON D, BROWDER TE, CASSEL DG, CHO HA, COFFMAN DM, DRELL PS, EHRLICH R, GALIK RS, GARCIASCIVERES M, GEISER B, GITTELMAN B, GRAY SW, HARTILL DL, HELTSLEY BK, JONES CD, JONES SL, KANDASWAMY J, KATAYAMA N, KIM PC, KREINICK DL, LUDWIG GS, MASUI J, MEVISSEN J, MISTRY NB, NG CR, NORDBERG E, OGG M, PATTERSON JR, PETERSON D, RILEY D, SALMAN S, SAPPER M, WORDEN H, WURTHWEIN F, AVERY P, FREYBERGER A, RODRIGUEZ J, STEPHENS R, YELTON J, CINABRO D, HENDERSON S, KINOSHITA K, LIU T, SAULNIER M, SHEN F, WILSON R, YAMAMOTO H, ONG B, SELEN M, SADOFF AJ, AMMAR R, BALL S, BARINGER P, COPPAGE D, COPTY N, DAVIS R, HANCOCK N, KELLY M, KWAK N, LAM H, KUBOTA Y, LATTERY M, NELSON JK, PATTON S, PERTICONE D, POLING R, SAVINOV V, SCHRENK S, WANG R, ALAM MS, KIM IJ, NEMATI B, ONEILL JJ, SEVERINI H, SUN CR, ZOELLER MM, CRAWFORD G, DAUBENMIER CM, FULTON R, FUJINO D, GAN KK, HONSCHEID K, KAGAN H, KASS R, LEE J, MALCHOW R, MORROW F, SKOVPEN Y, SUNG M, WHITE C, WHITMORE J, WILSON P, BUTLER F, FU X, KALBFLEISCH G, LAMBRECHT M, ROSS WR, SKUBIC P, SNOW J, WANG PL, WOOD M, BORTOLETTO D, BROWN DN, FAST J, MCILWAIN RL, MIAO T, MILLER DH, MODESITT M, SCHAFFNER SF, SHIBATA EI, SHIPSEY IPJ, WANG PN, BATTLE M, ERNST J, KROHA H, ROBERTS S, SPARKS K, THORNDIKE EH, WANG CH, DOMINICK J, SANGHERA S, SHELKOV V, SKWARNICKI T, STROYNOWSKI R, VOLOBOUEV I, ZADOROZHNY P, ARTUSO M, HE D, GOLDBERG M, HORWITZ N, KENNETT R, MONETI GC, MUHEIM F, MUKHIN Y, PLAYFER S, ROZEN Y, STONE S, THULASIDAS M, VASSEUR G, ZHU G, BARTELT J, CSORNA SE, EGYED Z, JAIN V, SHELDON P, AKERIB DS, BARISH B, CHADHA M, CHAN S, COWEN DF, EIGEN G, MILLER JS, OGRADY C, URHEIM J, WEINSTEIN A
The modernist angel: Art at the Limits of the Human in D. H. Lawrence, H. D. and Mina Loy
No full textPhDThe subject of this thesis is a figure that might provisionally be called the *modemist
angel'. Focusing on modernist literature, and more particularly on the work of D. H.
Lawrence, H. D. and Mina Loy, it aims to isolate from the many angels found in all periods
and all types of art a historically specific and intellectually coherent paradigm: an angel of
and for its modernist times. A figure of precisely this type could be said to exist in the
form of Walter Benjamin's 'angel of history'. Critics who address the question of the
modern angel in texts by Franz Kafka and Rainer Maria Rilke often do so in conjunction
with the problem posed by the angel of history. Beginning with a chapter on Benjamin,
this thesis nevertheless follows a different trajectory. Over five chapters, it explores a
modernist landscape formed not only by Lawrence, H. D. and Loy, but also by European
and American writers such as A. R. Orage, Allen Upward, Ezra Pound, Wallace Stevens,
Havelock Ellis, Edward Carpenter, Sigmund Freud and Friedrich Nietzsche. Although the
angel that emerges from this investigation might, in some respects, be said to anticipate
Benjamin's later version, this figure is also very different, standing for a project that is
distinctively, and recognisably, modernist in nature. He/she (the sex of the modernist
angel is often open to question) represents an attempt to reconcile the divine
responsibilities of the artist with the material and gendered conditions of being,
specifically of being human, in the modem world. This thesis looks again at the clash of
intellectual paradigms in the early-twentieth century - notably, the confrontation of the
Romantic view of art as a superhuman or sacred undertaking with the psychoanalytical or
evolutionary idea that all human endeavour is underpinned by sub-human motives - and
suggests the angel as a new and instructive figure through which to think the perilous
limits between the human and the divine in modernist literature
"A Lesson on a Tortoise" and D. H. Lawrence\u27s earliest crisis of social identity
No full textThe short story "A Lesson on a Tortoise", written by D. H. Lawrence in 1909, has traditionally been disregarded by criticism as a very minor piece of work. This paper aims to show that the story has a threefold importance: firstly as an autobiographical portrait of Lawrence\u27s activities as a teacher in Croydon; secondly as an example of Lawrence\u27s ability to use realistic techniques; and thirdly as a reflection of the author\u27s crisis of social identity. The paper concentrates on the last aspect and traces the personal and intellectual facets which came to shape Lawrence\u27s ideas on the subject
The Life of the Author: D. H. Lawrence
No full textThe Life of the Author: D. H. Lawrence is a focused exploration of the whole of the author’s life and writing career. Combining biographical detail and close readings of works in different genres, the book illuminates the complexities of Lawrence’s writing through a careful, questioning approach to biographical sources and recent scholarship. Andrew Harrison provides original insights into Lawrence’s relationship to working-class experience, his anti-suffragist feminist views, his reaction to the Great War, his responses to racial and cultural difference, his attitudes towards sex, sexuality, and sexual identity, and much more
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
New evidence for H/D scrambling of tryptophan and its analogues in the gas phase
No full textTryptophan and its analogues were analyzed using electrospray ionization quadrupole-time of flight (ESI-QTOF) combined with hydrogen deuterium exchange. The similar profiles of MS3 spectra of the product ions at m/z 190, 191, and 192 from [M (D)+D](+) for tryptophan by the losses of NH(D)(3) imply the same fragmentation patterns including the characteristic transfer of hydroxyl and very similar structures of these ions. This reveals the H/D scrambling prior to fragmentation. Compared the MS/MS spectrum of D-labelled compound 2 to the MS3 spectrum of m/z 191, it was found that amino group plays an important role for the H/D scrambling. The MS2 and MS3 spectra for D-labelled compound 4 indicate that the H/D scrambling involves the hydrogen on methyl linked to indole ring. In addition, the fragmentation of transfer of hydroxyl or methoxyl is confirmed by comparing the spectra of compounds 1-4. (C) 2015 Elsevier B.V. All rights reserved
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis
No full textMutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of CTSD deficiencies. To identify the early events that lead to synaptic alterations, we investigated synaptic ultrastructure and function in presymptomatic CTSD knockout (Ctsd) mice. Electron microscopy revealed that there were significantly greater numbers of readily releasable synaptic vesicles present in Ctsd mice than in wild-type control mice as early as postnatal day 16. The size of this synaptic vesicle pool continued to increase with disease progression in the hippocampus and thalamus of the Ctsd mice. Electrophysiology revealed a markedly decreased frequency of miniature excitatory postsynaptic currents (mEPSCs) with no effect on paired-pulse modulation of the evoked excitatory post synaptic potentials in the hippocampus of Ctsd mice. The reduced mEPSCs frequency was observed before the appearance of epilepsy or any morphologic sign of synaptic degeneration. Taken together, these data indicate that CTSD is required for normal synaptic function and that a failure in synaptic trafficking or recycling may bean early and important pathologic mechanism in Ctsd mice; these presynaptic abnormalities may initiate synaptic degeneration in advance of subsequent neuronal loss
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