48 research outputs found
The impact of social ties and gender diversity on earnings quality
No full textThis research investigates the influence of social ties between the CEOs and board members and the gender of these CEOs on the quality of the earnings, measured by earnings management. Several accounting scandals in the last years have increased the scrutiny on financial reporting and have highlighted the importance of good corporate governance. In order to reduce agency conflicts, the board should be independent and diversified. Social ties could impair the independence, although the prior literature fails to deliver conclusive results. This study expects a negative relation between socially connected CEOs and earnings quality. Gender diversity is also a heavily discussed topic in a business setting. The general belief is that women are more ethical at the workplace, suggesting that they engage in less earnings management and therefore higher earnings quality. A sample of 99 UK listed firms, comprising 198 observations covering the period of two years (2015 and 2016) is used to test the hypothesis. Although no significant results were found, which indicates no relation between social connectedness, gender and quality of the reported earnings, the study is important in advancing the knowledge about social ties and gender in earnings management
Corporate Social Responsibility in Tourism, How can a CSR certificate enhance the competitive advantage of tourism SMEs in Denmark – case study of Travelife Certification
No full textTowards a Resource-Aware Programming Architecture for Smart Autonomous Underwater Vehicles
No full textTechnical report DCS-TR-63
Фенотипизиране на бронхиалната астма
No full textЦЕЛ И ЗАДАЧИ
ЦЕЛ:
Да се формират и анализират отделни фенотипи на възрастни пациенти със средно-тежка и тежка бронхиална астма на базата на биометрични, функционални, клинични, възпалителни и имунологични характеристики и биомаркери и да се определи терапевтичното поведение чрез алгоритъм, приложим в рутинната клинична практика.
ЗАДАЧИ:
1. Да се определи и оцени клиничното значение на пола, възрастта, началото и продължителността на бронхиалната астма, коморбидностите и тютюнопушенето при възрастни пациенти със средно-тежка и тежка бронхиална астма и да се анализират техните асоциации с контрола, тежестта, възпалителните и имунологични маркери.
2. Да се определят контрола, честотата на екзацербациите, функционалните характеристики и тежестта на бронхиалната астма и да се анализират факторите свързани с тях.
3. Да се изследват и анализират атопичен статус, общи IgE, фракция на издишан азотен окис, кръвни еозинофили и C-реактивен протеин и да се потърси асоциация с останалите изследвани клинични и имунологични характеристики.
4. Да се изследват серумни нива на IL-5, IL-6, IL-8, IL-13, IL-17A и периостин и да се определят гранични стойности на базата на резултати получени при здрави контроли с цел дефиниране на групи с високи и ниски нива на серумните маркери и да се анализират техните различия.
5. Да се групират пациентите според утвърдени биомаркери и да се анализират различията в техния възпалителен и имунологичен профил.
6. Да се проведе непреднамерен клъстерен анализ с дефиниране на клъстерни групи в изследваната популация с цел идентифициране на отделни фенотипи.
7. Да се определи терапевтичното поведение чрез алгоритъм, приложим в рутинната клинична практика
Opportunities for implementing digital applications to monitor the impact of risk-minimization measures within the pharmacovigilance process: Scoping review of published literature
Full text linkThe study provides an overview of innovative digital solutions to meet the evolving needs of drug safety monitoring and improve patient outcomes, focusing on implementing digital applications to enhance the monitoring of additional risk-minimization measures (aRMMs) for pharmacovigilance. Over the last decade, the literature has highlighted a critical unmet need for improving the efficiency and accuracy of adverse event reporting. This is crucial for identifying risks not observed during clinical trials. Digital tools offer potential benefits by providing real-time reporting, comprehensive safety data, and increased patient engagement, thus addressing the challenges of underreporting and incomplete data in pharmacovigilance. The scoping review of the literature identified current global practices and evaluated the feasibility of adopting such solutions locally. The findings suggest digital tools such as mobile applications, web-based platforms, and electronic health record integrations are effective mechanisms for the collection of real-world data, patient-reported outcomes, and patient engagement in terms of drug safety surveillance. These tools address significant challenges inherent in traditional systems, such as underreporting and data fragmentation. Integrating digital solutions into pharmacovigilance can significantly enhance the timeliness and reliability of drug safety data, supporting more informed regulatory decision-making and ultimately improving patient outcomes
LSC - 2019 - Neutrophil gelatinase-associated lipocalin and IL-6 – markers predictors for exacerbations in Asthma- COPD overlap, compared to COPD and Asthma
No full text
Neutrophil gelatinase-associated lipocalin and IL-6 – markers predictors for exacerbations in Asthma- COPD overlap, compared to COPD and Asthma
No full textThe changing role of the manager in the digital era Findings from Erasmus IP LibCMASS 2012 Project
No full textCREATING AN ECO-CHEMICAL MODEL FOR UNIVERSITY, POSTGRADUATE PROFESSIONAL AND CONTINUING EDUCATION FOR THE PRESERVATION OF WRITTEN CULTURAL HERITAGE
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