1,721,155 research outputs found
Trattamento chirurgico dei tumori cutanei con la chirurgia microscopicamente controllata di Mohs
No full textPrevention of erlotinib-induced folliculitis with doxycycline
No full textDeplanque et al. (2016) reported their experience after doxycycline
administration in the prevention of erlotinib-induced folliculitis in
patients affected by non-small-cell lung cancer (NSCLC). The oral epidermal
growth factor receptor (EGFR), tyrosine kinase inhibitor erlotinib,
is a second-line monotherapy for advanced NSCLC in patients with
disease progression after first-line platinum-based therapy, recently
approved also as first-line treatment for patients with EGFR mutationpositive
NSCLC. Erlotinib is generally well tolerated. The most common
side effects include skin toxicity, such as rash (folliculitis or acneiform
rash/papulopustular eruption), xerosis, paronychia, pruritus, hair
growth, and ocular disorders. Cutaneous adverse events may prejudice
patient compliance, leading to dose reduction, treatment delay, or
withdrawal.
The authors randomized patients into two group
New data on the use of the FISH technique: the horizon dividing Spitz nevi and melanoma in childhood moves even further away
No full text
Non-Coding RNA Investigations in Cutaneous Melanoma: A Step forward in Discovering Novel Biomarkers
No full textN
Percutaneous absorption of crotamiton in man following single and multiple dosing Cutan Ocul Toxicol
No full textAbstract
PURPOSE: Crotamiton is a topical drug used in the treatment of scabies and pruritus. We determined its percutaneous absorption following single and multiple dosing in normal skin. METHODS: We used in vivo measurement of percutaneous absorption of [14C] crotamiton in a multidose regimen by measuring urinary excretion and liquid scintillation counting in three groups of four healthy volunteers. The Feldmann urinary excretion method was utilized to ascertain percutaneous absorption. Our results showed that tape stripping does not increase percutaneous absorption of crotamiton; upon repeated application
Oral pigmentation in physiologic conditions, post-inflammatory affections and systemic diseases
No full textMelanocytes are found throughout the oral mucosa but usually go unnoticed because of their relatively low level of pigment production. When focally or generally active in pigment production or proliferation they may be responsible for several affections in the oral mucosae ranging from physiologic pigmentation, systemic diseases to malignant neoplasms. The diagnosis of oral pigmentations (OP) is usually challenging for the physician, but a careful examination of the oral cavity may reveal the first manifestation of underlying systemic diseases. Therefore, a full medical history (including drug assumption and smoking) together with a general dermatological examination are mandatory and represent the first approach to OPs. When the diagnosis cannot be reached clinically with enough certainty, a biopsy for histological examination is needed, also in order to exclude possible life threatening conditions such as melanoma. Dermoscopy is another reliable diagnostic tool to make a differential diagnosis between melanocytic lesions and other conditions and then to manage the follow-up of patients. Few papers on the subject have been published in the dermatological literature and the oral cavity is often poorly investigated during routine dermatological examinations. We therefore decided to perform a review of benign OPs, classifying them into diffuse (physiological/racial pigmentations, smoker's melanosis, drug-induced hyperpigmentation, post-inflammatory hyperpigmentation, black hairy tongue, OPs associated to systemic diseases) and localized (amalgam tattoo, melanocytic nevi, melanoacanthoma, melanosis) lesions
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