706 research outputs found
Noordwolde, Wolddijk 72, Gemeente Bedum (Gr.). Archeologische Begeleiding II.
No full textIn februari 2014 is in plangebied Wolddijk 72 te Noordwolde, gemeente Bedum (Gr.), een archeologische begeleiding uitgevoerd bij het uitgraven van de fundering voor een werktuigberging achter een boerderij (Dijk 2014). Hierna heeft de opdrachtgever besloten om ook het woonhuis van de boerderij te slopen en te herbouwen. Na de sloop heeft De Steekproef op 13 oktober 2014 het ontgraven van de bouwput archeologisch begeleid. De graafwerkzaamheden bestonden uit het uitgraven van een 12 x 14 meter grote bouwput. Het voormalige woonhuis had een oppervlak van 10 x 12 = 120 m2.
De archeologische begeleiding werd uitgevoerd naar aanleiding van de aanwezigheid van een huiswierde ter hoogte van het perceel. Deze huiswierde is op basis van een booronderzoek door Miedema in 1975 als laat-middeleeuws gedateerd (Miedema 1983). Het terrein is op de Archeologische Monumentenkaart (AMK) aangegeven als terrein van hoge archeologische waarde (AMK-nr. 6865). Voor het bureauonderzoek van de archeologische begeleiding wordt verwezen naar Dijk (2014).
Bij de begeleiding van het graafwerk voor het woonhuis, beschreven in dit rapport, werden geen archeologische sporen ontdekt. Het is zeer aannemelijk dat er door de bouw en sloop van het woonhuis sporen zijn verdwenen. Wel zijn er, net als op het terrein van de nieuwe werktuigberging (Dijk 2014), enkele scherven aardewerk gevonden die in de late middeleeuwen en nieuwe tijd zijn te dateren.
Op basis van de begeleiding in februari (Dijk 2014) werd vastgesteld dat een archeologische vindplaats zich meest waarschijnlijk naar het zuiden en waarschijnlijk ook naar het oosten en westen van de nieuwbouw uitbreidt. Daarom werd voor dat deel van het plangebied bij eventueel volgende grote bodemingrepen een proefsleuvenonderzoek geadviseerd om daarmee de aard en omvang van de vindplaats beter in beeld te krijgen. Bij kleine ingrepen, zoals het ingraven van kabels en leidingen, kan worden volstaan met archeologische begeleiding. In het noorden is de kans op archeologische grondsporen en/of vondsten kleiner, maar niet uit te sluiten. Daarom werd voor het noorden van het plangebied (ten noorden van de boerderij) geadviseerd om eventuele bodemingrepen archeologisch te laten begeleiden. Naar aanleiding van deze eerdere begeleiding (Dijk 2014) werd het niet noodzakelijk geacht om de status en omvang van AMK-terrein 6865, het erf van de boerderij aan de Wolddijk 72, te veranderen.
De resultaten van de archeologische begeleiding van het graafwerk voor het woonhuis (het voorliggende rapport) geven geen aanleiding om van dit advies af te wijken
Conserved and variable correlated mutations in the plant MADS protein network
No full textAbstract Background Plant MADS domain proteins are involved in a variety of developmental processes for which their ability to form various interactions is a key requisite. However, not much is known about the structure of these proteins or their complexes, whereas such knowledge would be valuable for a better understanding of their function. Here, we analyze those proteins and the complexes they form using a correlated mutation approach in combination with available structural, bioinformatics and experimental data. Results Correlated mutations are affected by several types of noise, which is difficult to disentangle from the real signal. In our analysis of the MADS domain proteins, we apply for the first time a correlated mutation analysis to a family of interacting proteins. This provides a unique way to investigate the amount of signal that is present in correlated mutations because it allows direct comparison of mutations in various family members and assessing their conservation. We show that correlated mutations in general are conserved within the various family members, and if not, the variability at the respective positions is less in the proteins in which the correlated mutation does not occur. Also, intermolecular correlated mutation signals for interacting pairs of proteins display clear overlap with other bioinformatics data, which is not the case for non-interacting protein pairs, an observation which validates the intermolecular correlated mutations. Having validated the correlated mutation results, we apply them to infer the structural organization of the MADS domain proteins. Conclusion Our analysis enables understanding of the structural organization of the MADS domain proteins, including support for predicted helices based on correlated mutation patterns, and evidence for a specific interaction site in those proteins.</p
Coexistence Between Ultra-Wideband Radio and Narrow-Band Wireless LAN Communication Systems-Part I: Modeling and Measurement of UWB Radio Signals in Frequency and Time
No full textThe correct modeling and measurement of ultra-wideband (UWB) radio signal are a critical issue to evaluate the electromagnetic (EM) emission of any communication system based on this technology. In this paper (Part I), UWB radio communication systems based on impulse radio (IR) and multiband orthogonal frequency division multiplex (MB-OFDM) technologies are characterized by simulations and experiments in both frequency and time domains. The EM characteristics of UWB radio are measured by different methods (conducted and radiative) and in different environments (anechoic and reverberation chambers)
ASIC FFT processor for MB-OFDM UWB system
No full textThe physical layer (PHY) standard of Multi-band Orthogonal Frequency Division Multiplexing (MB-OFDM) Ultra Wideband (UWB) system was defined by ECMA International. In this standard, the data sampling rate from the analog-to-digital converter to the physical layer is up to 528 Msample/s. Therefore, it is a challenge to realize the physical layer of the UWB system-especially the components with high computational complexity in Very Large Scale Integration (VLSI) implementation. Fast Fourier Transform (FFT) block is one of these components. FFT plays an important role in Multi-band OFDM UWB system, which is the demodulation block of OFDM signals. The purpose of this project is to design an Application Specific Integrated Circuit (ASIC) FFT solution for this system. The specification is defined from the system analysis and literature research. All the design choices and considerations are concluded and explained.Based on the algorithm and architecture analysis, a novel Radix22Parallel processor is proposed, which is a small-area and low-power-consumption solution for MB-OFDM UWB system. Both Field Programmable Gate Array (FPGA) and ASIC targeted synthesis results of this architecture are presented.Electrical Engineering, Mathematics and Computer Scienc
Video guide to design flexible DNA.mp4
No full textModel file name: Video guide to design flexible DNA.mp4
Authors: Michelle E Howell, Karin van Dijk, Christine S Booth, Tomas Helikar, Brian A Couch, Rebecca L Roston
This 30-minute video includes step-by-step instructions to design and 3-D print a long flexible DNA model that mimics the structure and function of DNA. The instructions are applicable for designing the model using open-source 3-D computer graphics software Blender 2.79 which is available for download at https://www.blender.org/download/.
.mp4 file download (70 MB) below
Receiver Windowing Design for Narrowband Interference Mitigation in MB-OFDM UWB System
No full textIn 2005, the WiMedia Alliance working with the European Computer Manufacturers Association (ECMA) announced the establishment of the WiMedia MB-OFDM (Multiband Orthogonal Frequency Division Multiplexing) UWB radio platform as their global UWB standard. It was also chosen as the physical layer (PHY) of high data rate wireless specifications for high speed Wireless USB (W-USB), Bluetooth 3.0 and Wireless High-Definition Media Interface (HDMI). However, due to the low power and wide bandwidth nature of UWB systems, in-band narrowband interference (NBI) may hinder the receiver performance. This thesis presents an analysis of NBI impact on the MB-OFDM system for UWB communication. The intent of our analysis is to provide practical solutions for interference mitigation under different NBI models. In our work, a new receiver windowing for zero padding (ZP) OFDM system is proposed to reduce NBI spreading in the MB-OFDM UWB system. Simulations demonstrate the effectiveness of windowing under different NBI models.Microelectronics & Computer EngineeringElectrical Engineering, Mathematics and Computer Scienc
Erratum to: Optimizing adalimumab treatment in psoriasis with concomitant methotrexate (OPTIMAP): Study protocol for a pragmatic, single-blinded, investigator-initiated randomized controlled trial. [Trials. 52, (2017), (18)] DOI: 10.1186/s13063-017-1777-y
No full textThe author initials were not complete in the original publication [1]. The correct initials should be: "CI Busard, SP Menting, JS van Bezooijen, JM van den Reek, BA Hutten, EP Prens, EM de Jong, MB van Doorn, PI Spuls"
Mediterranean diet and the metabolic syndrome
No full textMediterranean diet and the metabolic syndrome Background: The metabolic syndrome refers to a clustering of risk factors including abdominal obesity, hyperglycaemia, low HDL-cholesterol, hypertriglyceridaemia, and hypertension and it is a risk factor for diabetes mellitus type 2 and cardiovascular disease. In this thesis we studied whether a Mediterranean diet favourably affects the metabolic syndrome. Methods: We assessed the association between a Mediterranean diet and the metabolic syndrome in apparently healthy elderly European subjects (SENECA study) and in a Dutch study population that was oversampled with subjects with impaired glucose tolerance or diabetes mellitus type 2 (CoDAM study). In addition, we conducted a controlled-feeding trial to compare the effects of replacing a high saturated fatty acids (SFA) diet with a high monounsaturated fatty acids (MUFA) diet or a Mediterranean diet on characteristics of the metabolic syndrome: HDL-cholesterol, triglycerides and glucose metabolism (glucose concentration and insulin sensitivity). Results: In both the SENECA study and the feeding trial we find support for the hypothesis that a Mediterranean diet has a beneficial effect on two characteristics of the metabolic syndrome, namely HDL-cholesterol and triglyceride concentrations. In addition, the findings of the SENECA study suggested that subjects with good adherence to a Mediterranean diet had a lower prevalence of the metabolic syndrome (prevalence ratio 0.81, 95%CI 0.65; 1.03) and a smaller waist circumference (-1.1 cm, 95%CI -2.4; 0.3) than subjects with poor adherence. In the CoDAM study, we did not find these associations. In none of our studies we found support for the hypothesis that a Mediterranean diet has a beneficial effect on glucose concentration, insulin sensitivity or blood pressure. Conclusion: This thesis finds support for a beneficial effect on two out of five characteristics of the metabolic syndrome and also suggests a beneficial effect on a third characteristic (abdominal obesity). We therefore conclude that a Mediterranean diet may help to prevent the metabolic syndrome and consequently diabetes mellitus type 2 and cardiovascular disease. <br/
Design of a Portable and Customizable Microprocessor for Rapid System Prototyping
No full textDue to the increasing number of processors which are integrated in System On Chips (SOCs) the need for robust, highly configurable processors emerged. Preliminary research showed that commercial processors are not suited for many research projects due to the fact that they are closed source and they can not be modified. Open source processors on the other hand appeared to be of too low quality. Within this thesis a light-weight instruction and cycle compatible implementation of the MicroBlaze architecture called mb-lite is presented to fill the need for a fast, reliable processor suitable for Field Programmable Gate Array (FPGA) and semi-custom implementation. This was accomplished by using a proven design methodology and using high-level VHDL abstractions. Experimental results showed that mb-lite is able to obtain much higher performance than existing open source processors, while using very few hardware resources. mb-lite can be easily extended with existing Intellectual Property (IP) components due to a wishbone bus adapter and a modular, easily configurable multiplexed memory bus. All components are thoroughly tested for compliance, and their functionality was proven to be correct using timing back-annotated simulations. Continued work on mb-lite will focus on including the design in a reconfigurable fabric as well as fabrication in a 90 nm semi-custom Integrated Circuit (IC) technology.Computer EngineeringMicroelectronics & Computer EngineeringElectrical Engineering, Mathematics and Computer Scienc
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