1,721,009 research outputs found
Ricordo di Franco Simone
Full text link«Ricordi di Franco Simone», m’a demandé Lionello Sozzi. Ces souvenirs sont limités dans le temps; je n’ai connu Franco Simone que tardivement, alors qu’il avait rencontré la célébrité bien avant les années 70. Il avait été professeur invité au Collège de France dès 1961. Harvard fut son ultime expérience à l’étranger. Il en revint pour des tâches en apparence plus modestes: sans doute par attachement au pays natal. Nous avions été l’un et l’autre, par nos ancêtres immédiats, et pendant des centaines d’années, d’anciens compatriotes. Qu’il ait voulu se consacrer à aider la future Université de Savoie, il y voyait, bien au-delà des relations personnelles amicales, une manière de consacrer sa carrière par une décision d’européen convaincu, au service de la jeunesse.«Ricordi di Franco Simone» asked Lionello Sozzi. My memories are limited in time. I only met Franco Simone in the 70s towards the end of his career, although he had met with fame long before then. He had been visiting professor at the Collège de France as early as 1961. Harvard was his last foreign venture. He returned, undoubtedly by attachment to his native land, to pursue seemingly more modest projects. We were long-standing compatriots tied by ancestors both immediate and stretching back hundreds of years. His decision to dedicate himself to helping the future Université de Savoie was, beyond the relationships of friendship involved, a way of consecrating his career with a firmly European action in the service of youth
Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype
Full text linkColon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metastatic potential of CRC stem cells (CR-CSCs) in obese patients
The miRNA Contribution in Adipocyte Maturation
Full text linkMesenchymal stem cells, due to their multipotent ability, are considered one of the best candidates to be used in regenerative medicine. To date, the most used source is represented by the bone marrow, despite the limited number of cells and the painful/invasive procedure for collection. Therefore, the scientific community has investigated many alternative sources for the collection of mesenchymal stem cells, with the adipose tissue representing the best option, given the abundance of mesenchymal stem cells and the easy access. Although adipose mesenchymal stem cells have recently been investigated for their multipotency, the molecular mechanisms underlying their adipogenic potential are still unclear. In this scenario, this communication is aimed at defining the role of miRNAs in adipogenic potential of adipose-derived mesenchymal stem cells via real-time PCR. Even if preliminary, our data show that cell culture conditions affect the expression of specific miRNA involved in the adipogenic potential of mesenchymal stem cells. The in vitro/in vivo validation of these results could pave the way for novel therapeutic strategies in the field of regenerative medicine. In conclusion, our research highlights how specific cell culture conditions can modulate the adipogenic potential of adipose mesenchymal stem cells through the regulation of specific miRNAs
Designing an Intelligent Cyber-Biological System for Enhanced Analysis and Monitoring of Organoids
No full textOrganoids replicate key aspects of organ function and present a microcosmic representation of the in-vivo state, offering unprecedented opportunities for disease modeling, drug testing, and personalized medicine. However, the complexity of these heterogeneous biological models requires innovative approaches to optimize the analysis and monitoring. This work outlines an Intelligent Cyber-Biological System (ICBS) with a multi-layered MAPE-K structure for enhanced analysis and real-time organoid monitoring. Starting with the Laboratory Layer, the ICBS harnesses real-time data from organoid cultures, which the Data Layer processes and archives for insight extraction. The Intelligence Layer employs advanced machine learning (ML) models for pattern recognition and predictive analytics, identifying critical development stages and treatment responses. In the Decision Layer, perceptions derived from ML-generated guide strategic decision-making for culture condition adjustments and further examinations. The ICBS framework engages researchers in its findings, fostering decision implementation and a responsive feedback system. Its real-world application in the intestinal organoid case study demonstrates the feasibility and effectiveness of the proposed solution, increasing the efficiency of experimental processes and the predictive accuracy of treatment outcomes
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
- …
