102,112 research outputs found
Transparent and scalable client-side server selection using netlets
No full textReplication of web content in the Internet has been found to improve service response time, performance and reliability offered by web services. When working with such distributed server systems, the location of servers with respect to client nodes is found to affect service response time perceived by clients in addition to server load conditions. This is due to the characteristics of the network path segments through which client requests get routed. Hence, a number of researchers have advocated making server selection decisions at the client-side of the network. In this paper, we present a transparent approach for client-side server selection in the Internet using Netlet services. Netlets are autonomous, nomadic mobile software components which persist and roam in the network independently, providing predefined network services. In this application, Netlet based services embedded with intelligence to support server selection are deployed by servers close to potential client communities to setup dynamic service decision points within the network. An anycast address is used to identify available distributed decision points in the network. Each service decision point transparently directs client requests to the best performing server based on its in-built intelligence supported by real-time measurements from probes sent by the Netlet to each server. It is shown that the resulting system provides a client-side server selection solution which is server-customisable, scalable and fault transparent
MENU: multicast emulation using netlets and unicast
No full textHigh-end networking applications such as Internet TV and software distribution have generated a demand for multicast protocols as an integral part of the network. This will allow such applications to support data dissemination to large groups of users in a scalable and reliable manner. Existing IP multicast protocols lack these features and also require state storage in the core of the network which is costly to implement. In this paper, we present a new multicast protocol referred to as MENU. It realises a scalable and a reliable multicast protocol model by pushing the tree building complexity to the edges of the network, thereby eliminating processing and state storage in the core of the network. The MENU protocol builds multicast support in the network using mobile agent based active network services, Netlets, and unicast addresses. The multicast delivery tree in MENU is a two level hierarchical structure where users are partitioned into client communities based on geographical proximity. Each client community in the network is treated as a single virtual destination for traffic from the server. Netlet based services referred to as hot spot delegates (HSDs) are deployed by servers at "hot spots" close to each client community. They function as virtual traffic destinations for the traffic from the server and also act as virtual source nodes for all users in the community. The source node feeds data to these distributed HSDs which in turn forward data to all downstream users through a locally constructed traffic delivery tree. It is shown through simulations that the resulting system provides an efficient means to incrementally build a source customisable secured multicast protocol which is both scalable and reliable. Furthermore, results show that MENU employs minimal processing and reduced state information in networks when compared to existing IP multicast protocols
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
P2.27 Full exome resequencing by next generation sequencing (NGS) combined with chip analysis for the genetic testing of unclassified myopathic patients
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
A community-based resource for automatic exome variant-calling and annotation in Mendelian disorders.
No full textMendelian disorders are mostly caused by single mutations in the DNA sequence of a gene, leading to a phenotype with pathologic consequences. Whole Exome Sequencing of patients can be a cost-effective alternative to standard genetic screenings to find causative mutations of genetic diseases, especially when the number of cases is limited. Analyzing exome sequencing data requires specific expertise, high computational resources and a reference variant database to identify pathogenic variants.We developed a database of variations collected from patients with Mendelian disorders, which is automatically populated thanks to an associated exome-sequencing pipeline. The pipeline is able to automatically identify, annotate and store insertions, deletions and mutations in the database. The resource is freely available online http://exome.tigem.it. The exome sequencing pipeline automates the analysis workflow (quality control and read trimming, mapping on reference genome, post-alignment processing, variation calling and annotation) using state-of-the-art software tools. The exome-sequencing pipeline has been designed to run on a computing cluster in order to analyse several samples simultaneously. The detected variants are annotated by the pipeline not only with the standard variant annotations (e.g. allele frequency in the general population, the predicted effect on gene product activity, etc.) but, more importantly, with allele frequencies across samples progressively collected in the database itself, stratified by Mendelian disorder.We aim at providing a resource for the genetic disease community to automatically analyse whole exome-sequencing samples with a standard and uniform analysis pipeline, thus collecting variant allele frequencies by disorder. This resource may become a valuable tool to help dissecting the genotype underlying the disease phenotype through an improved selection of putative patient-specific causative or phenotype-associated variations
HOCTAR database: A unique resource for microRNA target prediction
No full textAbstractmicroRNAs (miRNAs) are the most abundant class of small RNAs in mammals. They play an important role in regulation of gene expression by inducing mRNA cleavage or translational inhibition. Each miRNA targets an average of 100–200 genes by binding, preferentially, to their 3′ UTRs by means of partial sequence complementarity. Most miRNAs are localized within transcriptional units, termed host genes, and show similar expression behavior with respect to their corresponding host genes. Considering the impact of miRNA in the regulation of gene expression and their involvement in a growing number of human disorders, it is vital to develop sensitive computational approaches able to identify miRNA target genes. The HOCTAR database (db) is a publicly available resource collecting ranked list of predicted target genes for 290 intragenic miRNAs annotated in human. HOCTARdb is a unique resource that integrates miRNA target prediction genes and transcriptomic data to score putative miRNA targets looking at the expression behavior of their host genes. We demonstrated, by testing 135 known validated target genes (either at the translational or transcriptional level) for different miRNAs, that the miRNA target prediction lists present in HOCTARdb are highly reliable. Moreover, HOCTARdb associates biological roles to each miRNA-controlled transcriptional network by means of Gene Ontology analysis. This information is easily accessible through a user-friendly query page. The HOCTARdb is available at http://hoctar.tigem.it/. We believe that a detailed relationship between miRNAs and their target genes and a constant update of the information contained in HOCTARdb will provide an extremely valuable resource to assist the researcher in the discovery of miRNA target genes
The Right to Strike under the United States Constitution: Theory, Practice, and Possible Implications for Canada
No full textAnswering critics of the Canadian Supreme Court's judgment in B.C. Health, the author argues that the Court laid the foundation for a principled and durable doctrine protecting constitutional labour rights, one that goes directly to the heart of the matter — the inequality of workers’ power in the employment relation. In the author’s view, two paths could lead from B.C. Health to the recognition of Charter protec- tion for a right to strike: one that treats the right as an accessory to col- lective bargaining, and one that upholds the right directly on the basis of the Charter values of equality and participation. The author supports the latter approach, contending that constitutional rights should be defined in relation to fundamental values, in a way that is not contingent on time-bound or fact-sensitive assessments about the role of strikes within a particular collective bargaining regime. Although a Charter right to strike may involve the courts in difficult choices about when to defer to legislative policy decisions, and courts may lack the institutional capac- ity to deal effectively with labour law issues, the author points out that judges can look to ILO standards for expert guidance. Noting that the U.S. experience in this area might be of considerable use to Canadians, the author concludes by providing an overview of American case law concerning a constitutional right to strike.Peer reviewe
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