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Vasküler risk faktörleri bulunan asemptomatik ve semptomatik hastalarda aspirin direnci ve trombosit glikoprotein IIIa gen polimorfizminin rolü
No full textVasküler hastalıklardan korunmada yaygın olarak kullanılan aspirin, her hastada
istenen etkinliği gösterememekte ve aspirin tedavisi altında tekrarlayıcı iskemik
olaylar görülebilmektedir. Gelisiminde birçok mekanizmanın öne sürüldüğü, “aspirin
direnci” olarak tanımlanan bu durumun sıklığı, yüksek riskli hastalarda %5-45 olarak
bildirilmektedir. Çalısmamız vasküler risk faktörleri bulunan hastalarda, aspirin
direnci oranı ile aspirin dozu, preparat özelliği ve glikoprotein IIIa PlA1/A2
polimorfizmi arasındaki iliskiyi belirlemek amacıyla planlanmıstır.
Vasküler risk faktörü bulunan, birincil ya da ikincil korunma için aspirin kullanan
208 hasta çalısmaya alındı. Hastalar aspirin kullanımlarına ve kliniklerine göre
gruplandırıldı. Akut iskemik inme kliniği ile basvuran 75 hasta semptomatik, inme
dısı nedenlerle takip edilen 133 hasta ise asemptomatik kabul edildi. Semptomatik
olan hastalar, inme sırasındaki aspirin kullanma durumlarına göre iki gruba ayrıldı.
Hastalarda PFA-100 sistemi (Col/Epi kartusu) ile aspirin direnci ölçüldü ve
glikoprotein IIIa PlA1/A2 polimorfizmleri PCR tekniği ile belirlendi. Tüm gruplar
bir arada değerlendirildiğinde aspirin direnci oranı %32,2 olarak saptandı. Direnç
saptanan hastaların yas ortalaması istatistiksel olarak anlamlı oranda yüksekti
(p=0,009).
Asemptomatik grup ile “aspirin kullanırken semptomatik olan” grubun direnç
oranları benzerdi. En yüksek direnç oranı (%39,3)100 mg enterik kaplı preparat
kullanan hastalarda saptandı. Aspirin dozunun artırılması ve/veya enterik kaplı
olmayan preparatlara geçilmesi %36 ile %60 arasında değisen oranlarda aspirine
duyarlılık sağladı. Daha önce aspirine duyarlı olduğu gösterilen hastalarda
tekrarlayan ölçümlerde zaman içinde %14 oranında aspirin direnci gelisimi olduğu
gözlendi. GpIIIa PlA1/A2 polimorfizmi ile aspirin direnci ve aterotrombotik inme
gelisimi arasında anlamlı iliski saptanmadı.
Sonuç olarak aspirinin etkisinde doz ve preparat özelliğine bağlı olarak ve zaman
içinde değisiklik görülebilmektedir. GpIIIa PlA1/A2 polimorfizmi ile aspirin direnci
ve aterotrombotik inme gelisimi arasında iliski gösterilememistir.
Aspirin, a widely used drug for prevention from vascular diseases, may not reveal the
desired effect in all patients and recurrent ischemic events may occur despite aspirin
therapy. Defined as “aspirin resistance”, this entity is reported in 5–45% of high risk
patients and various mechanisms have been proposed for its development. This study
is planned to determine whether there is a relationship between aspirin resistance and
aspirin dosage, preparation type and glycoprotein IIIa P1A1/A2 polymorphism in
patients with vascular risk factors.
208 patients with vascular risk factors, using aspirin for primary or secodary
prevention were included.in the study. Patients were classified according to their
clinical presentations and aspirin usage. Seventy-five patients, with acute ischemic
stroke presentation were grouped as symptomatic and the remaining 133 patients
were grouped as asymptomatic. Symptomatic group was further classified into two
groups, according to the aspirin usage status at the time of stroke. Aspirin resistance
was measured by PFA-100 system (Col/Epi cartridge) and glycoprotein IIIa
P1A1/A2 polymorphism were determined by PCR. The overall prevalance of aspirin
resistance was 32,2%. The mean age of patients with aspirin resistance were
significantly higher (p=0,009).
The prevalance of aspirin resistance were similar for both “symptomatic under
aspirin therapy” and asymptomatic groups. The resistance rate was found to be
highest with 100 mg enteric coated preparation usage (39,3%). Increasing the aspirin
dosage and/or shifting to non-enteric coated preparations revealed aspirin sensitivity
change between 36% and 60%. Repeated measurements revealed aspirin resistance
development in time course in 14% of patients shown to be aspirin sensitive before.
No significant relationship between glycoprotein IIIa P1A1/A2 polymorphism and
aspirin resistance and atherotrombotic stroke development is found.
In conclusion, the effect of aspirin can change by time, dosage and preparation.type
used. A relationship between glycoprotein IIIa P1A1/A2 polymorphism and aspirin
resistance and atherotrombotic stroke development cannot be found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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