141 research outputs found
Dataset in support of the journal article '3D printing of personalised carvedilol tablets using selective laser sintering'
No full textUnderlying μCT Data for "3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering"
by Atabak Ghanizadeh Tabriz, Quentin Gonot-Munck, Arnaud Baudoux, Vivek Garg, Richard Farnish, Orestis L. Katsamenis, Ho-Wah Hui, Nathan Boersen, Sandra Roberts, John Jones, and Dennis Douroumis
published in MDPI pharmaceutics
In section: Physical Pharmacy and Formulation, Recent Non-oral Dosage Form Development: Focus on 3D-Printed Formulations
The micro- and macro-porosities of representative 3D-printed tablets at 25%, 40%, and 55% laser intensities was measured. SLS-printed components were also characterised by means of X-ray microfocus computed tomography (μCT). Imaging was performed at the University of Southampton’s μ-VIS X-ray Imaging Centre (www.muvis.org) using a customised μCT scanner optimised for 3D X-ray histology (www.xrayhistology.org). The system, which is based on Nikon’s XTH225ST system (Nikon Metrology UK Ltd.)</span
Quantum dots synthesis and biological applications as imaging and drug delivery systems
No full textSemiconductor quantum dots (QDs) synthesized by metal ions and colloid stabilizers have been explored as promising probes in advanced imaging techniques, tumor diagnostic agents, and drug delivery systems. The ability to modulate QDs surface chemistry through particle—shape control, surface coating, and surface functionalization—has rendered them a valuable tool in biological sciences. The tremendous advances in nanotechnology revealed the unique properties of QD crystals in both in vitro and in vivo conditions. In this review, we summarize the recent trends in QD synthesis, surface modification, and biological applications particularly for cancer targeting and treatment
Development and evaluation of Cetirizine HCl taste-masked oral disintegrating tablets
No full textThe purpose of the current study was to mask the taste of cetirizine HCl and to incorporate the granules produced in oral disintegrating tablets (ODT). The bitter, active substance was coated by fluidized bed coating using Eudragit® RL30-D at levels between 15% and 40% w/w. The ODTs were developed by varying the ratio of superdisintegrants such as sodium croscarmellose, crospovidone grades and low substituted hydroxypropyl cellulose (L-HPC). A direct compression process was used to compress the ODTs under various compaction forces to optimize tablet robustness. The properties of the compressed tablets including porosity, hardness, friability and dissolution profiles were further investigated. The in vitro and in vivo evaluation of the tablet disintegration times showed almost identical rapid disintegration below 10 s at the optimal levels of each superdisintegrant. Finally, the taste and sensory evaluation in human volunteers demonstrated excellence in masking the bitter active and tablet palatability
Computational Resources and Infrastructures for a Novel Bioinformatics Laboratory: A Case Study
No full textIntroduction: Bioinformatics is a relatively recent multidisciplinary research field continuously offering novel opportunities. Although many researchers are actively working in/with bioinformatics, some research centers still face difficulties in hiring bioinformaticians and establishing the appropriate (first) bioinformatics infrastructures and computational resources. In our research center, we started from scratch and established initial bioinformatics infrastructures for common use and also for the specific case of precision/personalized medicine. Case description: Here, we report a case study reflecting our specific needs and circumstances during the implementation of a novel bioinformatics laboratory. This involved the preparation of rooms, computer networks, computational resources novel designs, and upgrades to existing designs. Moreover, this work involved people from diverse areas and institutions, such as companies, institutional projects, informatics, and technical infrastructures services. Discussion and evaluation: The work resulted in the implementation of four novel designs dedicated to genomic medicine and in the adaptation of two existing designs dedicated to common use located in the dry-lab room. This is not an accurate and objective work, as it often depends on the available computer hardware and the target bioinformatics field(s). The four novel designs offered substantial improvements when compared to the upgraded designs, additionally corroborated by performance evaluations, which resulted in an overall highest performance of the novel designs. Conclusions: We present work that was developed over two years until completion with functioning infrastructure. This project enabled us to learn many novel aspects not only related to redundant disk technologies, but also related to computer networks, hardware, storage-management operating systems, file systems, performance evaluation, and also in the management of services. Moreover, additional equipment will be important to maintain and expand the potential and reliability of the bioinformatics laboratory. We hope that this work can be helpful for other researchers seeking to design their bioinformatics equipment or laboratories
Orally disintegrating dosage forms and taste-masking technologies; 2010
No full textIntroduction: In the last decade the development of orally disintegrating tablets (ODTs) and thin-film platforms has grown enormously in the field of pharmaceutical industry. A wide variety of new masking technologies combined with the aforementioned platforms have been developed in order to mask the taste of bitter active substances and achieve patient compliance. The commercial success and viability of such products requires the development of robust formulations with excellent palatability, disintegration times, physicochemical stability and pharmacokinetic profiles.
Areas covered: In this review, emerging taste-masking technologies applied to solid dosage form manufacturing are summarized. The unique features and principles of taste-masking approaches used with ODT platforms are discussed, including the advantages and limitations of each technology. A brief discussion is also included on the taste masking of thin-film technologies, owing to their similar applications and requirements.
Expert opinion: This review elucidates the unique features of current commercially available or highly promising ODT and thin-film technologies, along with taste-masking approaches used in the manufacturing of oral solid dosage forms. A better understanding of these drug delivery approaches will help researchers to select the appropriate platform, or to develop innovative products with improved safety, compliance and clinical value
EVALUATION OF 3D PRINTABILITY AND DRUG RELEASE OF DRUG-LOADED MICRONEEDLES
No full textMicroneedles (MNs) have powerful drug delivery abilities and have been considered a promising approach to enhancing the skin's permeability. MNs are commonly produced by traditional fabrication methods which may present several disadvantages. Therefore, in this dissertation, a new fabrication approach, named as Digital Light Processing (DLP), was employed to overcome the mentioned disadvantages. This printing technology was used to fabricate drug-loaded spear microneedles for sustained release applications. Biocompatible and biodegradable polymers: polyethylene glycol (PEG) and polyethylene glycol diacrylate (PEGDA) were used as the bio-based photocurable resins and carbamazepine (CBZ) as the model drug. In the MNs final prototype, the base is composed of PEGDA, and the needles are made of PEGDA / PEG loaded with CBZ. To ensure proper adherence to the building platform the structures were printed using 50 s of exposure time for the first layer and the optimized parameters, 3 mW/cm2 of UV intensity for 3 s, for the remaining layers. Whole printed MNs showed to have good printability and the tip angle was the most susceptible parameter to the printing process. Furthermore, all the printed MNs were consistent and presented a smooth surface. Post-printing curing conditions showed that ideal mechanical properties of the MNs base were obtained at 50 ˚C and 45 min. The influence of the total number of needles per design was evaluated and the design with higher needle thickness showed to be stronger as it presented higher fracture forces of 2.5 N/Needle. Both designs showed a good piercing capacity and no needle damage upon application, however, the array with a higher density of needles required a higher piercing force, 27 ± 2 mN/Needle. Lastly, the two designs with higher needle thickness demonstrated an increasing drug release throughout the entire experiment and after 5 h both designs had ~ 3 % of the drug released. Although only a tiny amount of drug was released throughout the printed MNs, these findings are promising and show the ability of DLP MNs to release drugs during extended periods.As micro-agulhas (Microneedles, MNs) têm capacidades de administração de fármacos significativas e têm sido consideradas uma abordagem muito promissora para melhorar a permeabilidade da pele. As MNs são geralmente fabricadas por métodos tradicionais que podem apresentar várias desvantagens. Desta forma, nesta dissertação, uma nova abordagem de fabricação, processamento digital de luz (Digital Light Processing, DLP) foi usada para ultrapassar as desvantagens mencionadas. Esta técnica de impressão foi utilizada para fabricar MNs com fármacos incorporados para libertação sustentada de fármacos. Polímeros biocompatíveis e biodegradáveis: o polietilenoglicol (PEG) e o polietilenoglicol diacrilato (PEGDA) foram utilizados como bioresinas fotocuráveis e a carbamazepina (CBZ) como medicamento modelo. No protótipo final das MNs, a base é composta por PEGDA, e as agulhas são feitas de PEGDA / PEG com CBZ. Para assegurar a adesão adequada à plataforma da impressão, as estruturas foram impressas utilizando 50 s de tempo de exposição para a primeira camada e os parâmetros optimizados obtidos, 3 mW/cm2 de intensidade UV durante 3 s, para as restantes camadas. Todas as MNs impressas demonstraram ter boa capacidade de impressão e o ângulo da agulha foi o parâmetro mais susceptível ao processo de impressão. Além disso, todas as MNs impressas eram consistentes e apresentavam uma superfície lisa. As condições de cura pós-impressão mostraram que as propriedades mecânicas ideais da base de MNs foram obtidas em 50 ˚C e 45 min. A influência do número total de agulhas por design foi avaliada e o design com maior espessura de agulha mostrou ser o mais forte, uma vez que apresentou maiores valores de forças de fratura de 2.5 N/Needle. Ambos os designs demostraram uma boa capacidade de perfuração e nenhum dano da agulha aquando da aplicação, contudo, o conjunto com maior densidade de agulhas exigia uma maior força de perfuração, 27 ± 2 mN/Needle. Por fim, os dois designs com agulhas mais espessas demonstraram uma libertação do fármaco crescente durante toda a experiência e após 5 h os dois designs tinham ~ 3 % do fármaco libertado. Embora apenas uma pequena quantidade de fármaco tenha sido libertada a partir das MNs, estes desenvolvimentos são promissores e demostram a capacidade da utilização de DLP para fabricação de MNs capazes de libertar fármacos durante períodos prolongados
3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering - Underlying Data
No full textUnderlying μCT Data for "3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering"
by Atabak Ghanizadeh Tabriz, Quentin Gonot-Munck, Arnaud Baudoux, Vivek Garg, Richard Farnish, Orestis L. Katsamenis, Ho-Wah Hui, Nathan Boersen, Sandra Roberts, John Jones, and Dennis Douroumis
published in MDPI pharmaceutics
In section: Physical Pharmacy and Formulation, Recent Non-oral Dosage Form Development: Focus on 3D-Printed Formulations
The micro- and macro-porosities of representative 3D-printed tablets at 25%, 40%, and 55% laser intensities was measured. SLS-printed components were also characterised by means of X-ray microfocus computed tomography (μCT). Imaging was performed at the University of Southampton’s μ-VIS X-ray Imaging Centre (www.muvis.org) using a customised μCT scanner optimised for 3D X-ray histology (www.xrayhistology.org). The system, which is based on Nikon’s XTH225ST system (Nikon Metrology UK Ltd.)
Data index
20230206_XRH_3299_OLK_PHAR08603-DOSF_40.zip
Dataset (including ORS Dragonfly analysis file) of object printed at 40% laser power
10 µm voxel size isotropic
20230206_XRH_3299_OLK_PHAR08616-DOSF.zip
Dataset (including ORS Dragonfly analysis file) of object printed at 55% laser power
10 µm voxel size isotropic
20230206_XRH_3299_OLK_PHAR08616-DOSF_25.zip
Dataset (including ORS Dragonfly analysis file) of object printed at 25% laser power
10 µm voxel size isotropic
SLS-3DP_OLK-CorrectRes.xlsx
Analysis results & graphs
X-ray CT analysis conducted using Dragonfly software (v. 2022.1.0.1231; Object Research Systems (ORS) Inc, Montreal, Canada, 2020; software available at http://www.theobjects.com/dragonfl
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