1,723,268 research outputs found

    Unveiling the Therapeutic Potential of Berberine in Rheumatoid Arthritis: A Comprehensive Study of Network Pharmacology, Metabolomics, and Intestinal Flora [Erratum]

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    Li B, Liu J, He C, Deng Z, Zhou X, Peng R. J Inflamm Res. 2024;17:10849—10869. The authors have advised the second listed corresponding author, Zhou Deng, is incorrect. The correct corresponding author is Xiaohong Zhou. The remaining details are correct. This error was introduced by the Editorial staff during the publication process

    The Singapore curriculum: Convergence, divergence, issues and challenges

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    In this concluding chapter we discuss how policy, programmatic and classroom curricula reflect, on the one hand, global features and tendencies, and on the other, distinct national traditions and practices. Through this examination, we relate what has been happening in Singapore to what has been happening in the world in terms of curriculum reform and globalization, and make clear how curriculum reform policy, curriculum development, and classroom enactment in Singapore have responded to globalization in distinctive ways. We conclude by identifying a set of issues, problems, and challenges that not only concern policymakers and reformers in Singapore but (which we believe) would be generally useful for policymakers, educators, and researchers in other countries

    Probing the seismic cycle timing with coseismic twisting of subduction margins

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    Assessing the timing of great megathrust earthquakes is together crucial for seismic hazard analysis and deemed impossible. Geodetic instrumentation of subduction zones has revealed unexpected deformation patterns at subduction segments adjacent to those that hosted recent mega-earthquakes: coastal sites move landward with faster velocities than before the earthquake. Here, we show observations from the largest and best-monitored megathrust earthquakes, and from a scaled analog model, to reveal that these events create coseismic and postseismic deformation patterns typical of a complete gear-like rotation about a vertical axis, hereafter called twisting. We find that such twisting alters the interseismic velocity field of adjacent subduction segments depending on the time since the last earthquake. Early interactions accelerate while late interactions decelerate local kinematics. This finding opens the possibility of using megathrust earthquakes, the characteristics of the twisting pattern, and the ensuing geodetic velocity changes, as a proxy for estimating the timing of the seismic cycle at unruptured segments along the margin.Satellite geodesy and downscaled laboratory experiments reveal that great subduction earthquakes trigger step changes in kinematics of neighboring segments. This signal is potentially informative of the timing of the seismic cycle

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Cryogenic rapid quenching simultaneously enhances the strength and ductility of steel–Aluminum composite plates

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    Roll-bonded steel–aluminum composite plates exhibit poor plasticity due to work hardening induced by severe plastic deformation. In this study, the mechanisms for improving the plasticity of steel–aluminum composite plates were investigated through liquid-nitrogen quenching from both material science and mechanical perspectives. From a materials science perspective, rapid cryogenic quenching forms numerous dislocation walls and cells within the Al matrix. These dislocation configurations effectively limit dislocation movement during tensile deformation. Additionally, the difference in thermal expansion properties between the steel and aluminum matrices generate significant microstrain near the interface, enhancing the back stress-induced strengthening effect. From a mechanical perspective, rapid cryogenic quenching increases the hardness and tensile strength of the aluminum matrix. A stronger aluminum matrix restricts the deformation of the steel matrix during tensile loading, delaying the onset of necking in the steel matrix. Additionally, the significant hardening of the aluminum matrix can cause the tensile specimen to bend, creating two potential necking points that divide the tensile strain, thereby significantly increasing the pre-necking deformation of the composite plate. Compared with untreated specimens, the tensile elongation and tensile strength of the specimens treated with rapid cryogenic quenching increased by 49.1% and 10.8%, respectively. This study provides a novel approach to simultaneously enhance the strength and plasticity of composite plates

    A 'V' Shaped Magnet Guideway Evaluated for High Temperature Superconducting Maglev

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    High temperature superconducting (HTS) maglev technology has developed rapidly since it was found possessing the unique characteristics of self-stabilizing suspension. Because HTS maglev needs to work in an external magnetic field environment, it is especially noteworthy to select the appropriate magnetic guideway which is commonly composed of permanent magnets especially for HTS maglev transport applications. With the combination of the conventional single-peak permanent magnetic guideway (PMG) and an individual 'V' shaped support structure, a better 'V' shaped guideway which can generate a higher external magnetic field is obtained. The simulation results indicate that this kind of PMG not only provides the HTS maglev with sufficient suspension performance, but also better guidance capability at the same time. With regard to the typical work condition (the 30 mm field cooling height, the 10 mm work height and the 10 mm lateral displacement), the levitation force and guidance force can be achieved to 6778 N/m and 2778 N/m, respectively. The study is referential to the magnet guideway optimization for the engineering application of HTS maglev

    Magnetic levitation systems assessment from transport engineering point of view: Background and future prospects

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    This article reviews and summarizes the technological characteristics of magnetic levitation (Ma-glev) transport systems from a transport engineering point of view, providing a summary of the international state of the art, research activities and most significant applications over the last five decades. The main development phases of the Maglev systems are included and illustrated in the broader context of the evolutionary process of the railway transport system. This paper aims to categorize and clearly explain the ba-sic principles, technologies and application fields of different Maglev transportation systems. Performances, potentials and limits of Maglev systems are analyzed in comparison with those of traditional wheel-on-rail based ones. Additionally, Maglev research needs are included. Particular attention is paid to Maglev systems based on high critical temperature superconductivity technology: on this, the Italian and Chinese experiences are reported. Finally, the current research frontier focused on the development of futuristic evacuated tube transport (ETT) systems with very high speed (close to 1,000 km/h) Maglev vehicles is examined. In this respect, the potential and the main scientific and technological aspects that still need to be explored and resolved are highlighted
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