13,756 research outputs found
Mr. Melvin J. Collier, RWWL AUC, June 2011
No full textThis video is a conversation with Mr. Melvin J. Collier. Mr. Collier talks about his book, "From Mississippi to Africa: A Journey of Discovery". Daniel Le, AUC Woodruff Library, is the interviewer
Interview Excerpt of Mr. Donald M. Crawford, Sr.
No full text(1948-2018) Donald Mitchell Crawford, Sr. (“DC”), musician, author, and educator, was born on May 24, 1948, and was a lifelong resident of Birmingham, AL. His father and mother owned and operated “C & S Charter Tours Bus Company,” the first black-owned bus company in the state of Alabama. Crawford was a 1966 graduate of Western Olin High School in Birmingham, AL. Crawford was an outstanding drum major, playing first chair alto saxophone under the tutelage of the late Amos F. Gordon, Sr. After high school, he received a music scholarship to Alabama State University (ASU) where he earned both his Bachelor’s and Master’s Degrees in Music Education and was later inducted into the “School of Music Hall of Fame” at ASU. He was the youngest ever inducted into the Alabama Jazz Hall of Fame. He was a veteran of the U.S. Army and performed with the 291 st and 283rd Army Band in Fort Bennett, GA. DC was Band Director at Jackson Olin High School and taught in the Birmingham School System for over thirty-five years. His love for music and performing lead him after his retirement to serve as Band Director for Miles College.
Crawford is the author of “The Wheels of the Birmingham Civil Rights Movement.” This book chronicles the lives of his late father and mother, Worcy and Christine Pride Crawford, and the role he and the company played in the Birmingham Civil Rights Movement
Enabling effect of manganese on L-DOPA-induced apoptosis in PC12 cells: role of oxidative stress
No full text
Role of oxidative stress in the manganese and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced apoptosis in PC12 cells.
No full textOxidative stress is thought to play a key role in the apoptotic death of several cellular systems, including neurons. Oxidative stress is proposed also as a mechanism of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- and manganese (Mn)-induced neuronal death. We have recently shown that Mn and the MPTP analogue 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine (2'Et-MPTP), which is metabolized by MAO-A to 1-methyl-4-(2'-ethylphenyl)-pyridinium ion, induce apoptosis in PC12 cells. In the present study, we evaluated the effects of deprenyl and the antioxidant drugs N-acetylcysteine (NAC) and ascorbic acid (AA) on Mn- and 2'Et-MPTP-induced apoptosis in PC12 cells. Apoptosis was tested by terminal deoxynucleotidyl transferase-mediated 2'-deoxy-uridine-5'-triphosphate nick end labelling (TUNEL) technique, flow cytometry and fluorescence microscopy. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Mn-induced apoptosis and decrease in cell viability was inhibited by the antioxidants NAC and AA. Deprenyl failed to inhibit the above Mn effects. Neither NAC, AA nor deprenyl were able to inhibit both 2'Et-MPTP-induced apoptosis and decrease in cell viability. These results confirm that apoptosis may be an important mechanism of cell death in MPTP- and Mn-induced parkinsonism. However, an oxidative stress mechanism may be recognized, at least in vitro, only in the Mn-induced apoptosis
On the mechanism of manganese enhancing effect on L-DOPA neurotoxicity: a microdialysis stdy in PC12 cells in vitro and in the striatum of freely moving rats
No full text
Enabling effect of manganese in L-DOPA-induced apoptosis in PC12 cells:role of oxidative stress
No full textOn the mechanism of manganese enhancing effect on L-DOPA neurotoxicity: a microdialysis study in PC12 cells in vitro and in the striatum of freely moving rats
No full textManganese and 1-methyl-4-(2'-ethylpheny1)-1,2,3,6-tetrahydropyridine induce apoptosis in PC12 cells.
No full textOxidative stress is thought to play a key role both in the neurotoxin MPTP- and manganese (Mn)-induced neurotoxicity and in apoptotic cell death. In the present study, we report that Mn and the MPTP analogue 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine (2'Et-MPTP), which is metabolized by MAO-A to 1-methyl-4-(2'-ethylphenyl)-pyridinium ion (at concentrations of 0.5 and 1.0 mM), induced apoptosis in PC12 cells. Apoptosis was tested by terminal deoxynucleotidyl transferase-mediated 2'-deoxy-uridine-5'-triphosphate nick end labelling (TUNEL) technique, flow cytometry and fluorescence microscopy. Both Mn and 2'Et-MPTP induced also a time-dependent decrease in cell viability, as determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Only Mn-induced apoptosis and decrease in cell viability were inhibited by the antioxidant ascorbic acid. We conclude that apoptosis may be an important mechanism of cell death in MPTP- and Mn-induced parkinsonism. However, an oxidative stress mechanism may be recognized only in the Mn-induced apoptosis
- …
