1,720,964 research outputs found
British Society for Allergy and Immunology (BSACI) Abstracts of the World Allergy Organization (WAO) & BSACI 2022 UK Conference 25th-27th April 2022, Edinburgh International Conference Centre (EICC)
No full textObjectives: lung function in early adulthood is an important determinant of all-cause mortality and COPD. We aimed to model data from multiple cohorts from pre-school age to physiological peak in early adulthood to derive FEV1/FVC trajectories. We then investigated the association of the derived trajectories with early-life risk factors and markers of cardiovascular risk in adulthood.Method: using latent profile modelling, we studied three population-based birth cohorts (ALSPAC, MAAS, IOW) with repeat spirometry data from childhood into early adulthood to identify trajectories of FEV1/FVC. We performed echocardiogram and measured seated systolic blood pressure in ~3200 participants in ALSPAC at age 24 years. We used multinomial logistic regression models to investigate early-life predictors of the derived trajectories. We then ascertained the extent of the association between the derived FEV1/FVC trajectories and blood pressure and echocardiographic markers of increased cardiovascular risk and stroke in later adulthood.Results: we identified four distinct FEV1/FVC ratio trajectories with strikingly similar latent profiles in three independent birth cohorts: Above average (49.5%); Average (38.3%); Below average (10.6%); and Persistently low (1.7%). Male gender and history of allergic symptoms (wheeze, cough, asthma and sensitization) were significant associates of diminished lung function trajectories in all cohorts. We found strong evidence of the increase in cardiovascular risk markers ascertained by echocardiography (including left ventricular mass indexed to height and carotid intima-media thickness) with decreasing FEV1/FVC trajectory (with p-values for the mean effects per trajectory ranging from 0.005 to 11.17×10−7). The average seated systolic blood pressure (mm Hg) increased significantly per decreasing FEV1/FVC trajectory (p = 2.8×10−9)Conclusions: childhood lung function trajectories may serve as important predictors in the development of not only future lung disease, but also the cardiovascular disease and multimorbidity in adulthood. Our findings highlight the importance of measuring lung function throughout childhood and early adulthood
Primary and secondary hepatic lymphomas diagnosed by image-guided fine-needle aspiration : a retrospective study of clincal and cytomorphologic findings
No full textObjectives: To explore the diagnosis of hematolymphoid
malignancies of the liver (hepatic lymphoma [HeL]) by
image-guided fine-needle aspiration (FNA), which can often
be difficult due to a low index of suspicion and nonspecific
patient presentations, especially in the rare cases where
the liver is the only site of disease (primary HeL [PHeL]).
Understanding the clinical setting in which such lesions
arise, as well as the cytomorphologic findings, may assist
cytopathologists in making an accurate diagnosis and
triaging samples for ancillary studies.----- Methods: In this retrospective study of 32 patients with
HeL, the largest such study to our knowledge, we review the
clinical and diagnostic features of HeL.----- Results: HeL and especially PHeL most commonly show
a diffuse large B-cell lymphoma phenotype and have a
poor prognosis (median survival of seven months). PHeL
is strongly associated with human immunodeficiency virus
infection (12/16 patients).----- Conclusions: Image-guided FNA with immediate evaluation
is a reliable means to obtain diagnostic material and triage
for ancillary tests
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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